ALTERNATE DAYS TREATMENT WITH TERIPARATIDE IN POSTSURGICAL HYPOPARATHYROIDISM

The conventional treatment of hypoparathyroidism consists of vitamin ID analogues in combination with oral calcium supplementation. This treatment modalities induce chronic hypercalciuria which leads to nephrocalcinosis, nephrolithiasis and renal insufficiency. Here we report the case of a 32-year-old woman who developed hypocalcemia and hypercalciuria under treatment with high doses of vitamin D analogs and oral calcium. She had cerebral calcification, nephrocalcinosis under this treatment. Stable calcium levels were achieved with synthetic human parathyroid hormone treatment that was given in alternate days. PTH appears to be an alternative and effective treatment in hypoparathyroidism

Quality Characteristics of Drip Irrigated Carnation (Dianthus caryophyllus L. cv. "Eilat") under Protected Conditions

International Symposium on Strategies Towards Sustainability of Protected Cultivation in Mild Winter Climate -- JAN 31, 2009 -- Antalya, TURKEYWOS: 000305334500042The interest in cut flower cultivation is increasing gradually because of internal market demand, climate advantages of our country and increase on the production of cut flower for export in recent years. 52% of the total cut flower production in Turkey consists of carnation. This study aims to determine the effects of different irrigation levels on flowering and flower quality of carnation (Dianthus caryophyllus L. cv. "Eilat") grown in plastic greenhouse and irrigated by a drip irrigation system under Mediterranean (Antalya) conditions. In the study, two irrigation intervals (I-1: 10 mm pan evaporation and I-2: 20 mm pan evaporation) and four pan coefficient levels (K-1=0.60 Epan, K-2=0.90 Epan, K-3=1.20 Epan and K-4=1.50 Epan) were applied based on the amount of evaporation measured by a Class A pan located in the greenhouse. Additionally, the effects of different irrigation levels on flowering and flower quality of carnation were statistically analyzed. Results showed that high frequency irrigations using high pan coefficients increased flower stem length, flower stem diameter, stem weight, flower diameter, vase life and yield compared to low frequency irrigation with lower pan coefficients.Scientific and Technological Research Council of Turkey (TUB.TAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK)The authors would like to thank the Scientific and Technological Research Council of Turkey (TUB.TAK) for financial support of the study and to Tempo Tarim Ltd. Company for providing carnation seedling

Fatigue is correlated with disease activity but not with the type of organ involvement in Behcet's syndrome: a comparative clinical survey

Objective. Fatigue is an important problem in inflammatory diseases and affects the quality of life (QoL). We aimed to evaluate the severity and impact of fatigue in Behcet's syndrome (BS) and to determine its association with type of organ involvement and gender

LEF1 supports metastatic brain colonization by regulating glutathione metabolism and increasing ROS resistance in breast cancer

More than half of all brain metastases show infiltrating rather than displacing growth at the macro-metastasis/brain parenchyma interface (MMPI), a finding associated with shorter survival. The Lymphoid Enhancer-binding Factor-1 (LEF1) is an epithelial-mesenchymal transition (EMT) transcription factor that is commonly overexpressed in brain-colonizing cancer cells. Here, we overexpressed LEF1 in an in vivo breast cancer brain colonization model. It shortened survival, albeit without engaging EMT at the MMPI. By differential proteome analysis, we identified a novel function of LEF1 as a regulator of the glutathione (GSH) system, the principal cellular redox buffer. LEF1 overexpression also conferred resistance against therapeutic GSH depletion during brain colonization and improved management of intracellular ROS. We conclude that besides EMT, LEF1 facilitates metastasis by improving the anti-oxidative capacity of epithelial breast cancer cells, in particular during colonization of the brain parenchyma