The brainstem reticular formation is a small-world, not scale-free, network

Recently, it has been demonstrated that several complex systems may have simple graph-theoretic characterizations as so-called ‘small-world’ and ‘scale-free’ networks. These networks have also been applied to the gross neural connectivity between primate cortical areas and the nervous system of Caenorhabditis elegans. Here, we extend this work to a specific neural circuit of the vertebrate brain—the medial reticular formation (RF) of the brainstem—and, in doing so, we have made three key contributions. First, this work constitutes the first model (and quantitative review) of this important brain structure for over three decades. Second, we have developed the first graph-theoretic analysis of vertebrate brain connectivity at the neural network level. Third, we propose simple metrics to quantitatively assess the extent to which the networks studied are small-world or scale-free. We conclude that the medial RF is configured to create small-world (implying coherent rapid-processing capabilities), but not scale-free, type networks under assumptions which are amenable to quantitative measurement

Is there an integrative center in the vertebrate brain-stem? A robotic evaluation of a model of the reticular formation viewed as an action selection device

Neurobehavioral data from intact, decerebrate, and neonatal rats, suggests that the reticular formation provides a brainstem substrate for action selection in the vertebrate central nervous system. In this article, Kilmer, McCulloch and Blum’s (1969, 1997) landmark reticular formation model is described and re-evaluated, both in simulation and, for the first time, as a mobile robot controller. Particular model configurations are found to provide effective action selection mechanisms in a robot survival task using either simulated or physical robots. The model’s competence is dependent on the organization of afferents from model sensory systems, and a genetic algorithm search identified a class of afferent configurations which have long survival times. The results support our proposal that the reticular formation evolved to provide effective arbitration between innate behaviors and, with the forebrain basal ganglia, may constitute the integrative, ’centrencephalic’ core of vertebrate brain architecture. Additionally, the results demonstrate that the Kilmer et al. model provides an alternative form of robot controller to those usually considered in the adaptive behavior literature

A High-Resolution Study of the HI Content of Local Group Dwarf Irregular Galaxy WLM

Dwarf irregular galaxies are unique laboratories for studying the interaction between stars and the interstellar medium in low mass environments. We present the highest spatial resolution observations to date of the neutral hydrogen content of the Local Group dwarf irregular galaxy WLM. We find that WLM's neutral hydrogen distribution is typical for a galaxy of its type and size and derive an HI mass of 6.3e7 Msun for WLM. In addition, we derive an HI extent for WLM of 30 arcmin, which is much less than the 45 arcmin extent found by Huchtmeier, Seiradakis, and Materne (1981). We show that the broken ring of high column density neutral hydrogen surrounding the center of WLM is likely the result of star formation propagating out from the center of the galaxy. The young stars and Ha emission in this galaxy are mostly correlated with the high column density neutral hydrogen. The gap in the central ring is the result of star formation in that region using up, blowing out, or ionizing all of the neutral hydrogen. Like many late-type galaxies, WLM's velocity field is asymmetric with the approaching (northern) side appearing to be warped and a steeper velocity gradient for the approaching side than for the receding side in the inner region of the galaxy. We derive a dynamical mass for WLM of 2.16e9 Msun.Comment: 38 pages, 15 figures, 5 tables, accepted by AJ, high resolution version at http://www.astro.wisc.edu/~kepley/kepley_wlm.p

On the criticality of inferred models

Advanced inference techniques allow one to reconstruct the pattern of interaction from high dimensional data sets. We focus here on the statistical properties of inferred models and argue that inference procedures are likely to yield models which are close to a phase transition. On one side, we show that the reparameterization invariant metrics in the space of probability distributions of these models (the Fisher Information) is directly related to the model's susceptibility. As a result, distinguishable models tend to accumulate close to critical points, where the susceptibility diverges in infinite systems. On the other, this region is the one where the estimate of inferred parameters is most stable. In order to illustrate these points, we discuss inference of interacting point processes with application to financial data and show that sensible choices of observation time-scales naturally yield models which are close to criticality.Comment: 6 pages, 2 figures, version to appear in JSTA

The Factory and The Beehive II. Activity and Rotation in Praesepe and the Hyades

Open clusters are collections of stars with a single, well-determined age, and can be used to investigate the connections between angular-momentum evolution and magnetic activity over a star's lifetime. We present the results of a comparative study of the relationship between stellar rotation and activity in two benchmark open clusters: Praesepe and the Hyades. As they have the same age and roughly solar metallicity, these clusters serve as an ideal laboratory for testing the agreement between theoretical and empirical rotation-activity relations at $\approx$600 Myr. We have compiled a sample of 720 spectra --- more than half of which are new observations --- for 516 high-confidence members of Praesepe; we have also obtained 139 new spectra for 130 high-confidence Hyads. We have collected rotation periods ($P_{rot}$) for 135 Praesepe members and 87 Hyads. To compare $H\alpha$ emission, an indicator of chromospheric activity, as a function of color, mass, and Rossby number $R_o$, we first calculate an expanded set of $\chi$ values, with which we can obtain the $H\alpha$ to bolometric luminosity ratio, $L_{H\alpha}/L_{bol}$, even when spectra are not flux-calibrated and/or stars lack reliable distances. Our $\chi$ values cover a broader range of stellar masses and colors (roughly equivalent to spectral types from K0 to M9), and exhibit better agreement between independent calculations, than existing values. We find no difference between the two clusters in their $H\alpha$ equivalent width or $L_{H\alpha}/L_{bol}$ distributions, and therefore take the merged $H\alpha$ and $P_{rot}$ data to be representative of 600-Myr-old stars. Our analysis shows that $H\alpha$ activity in these stars is saturated for $R_o\leq0.11^{+0.02}_{-0.03}$. Above that value activity declines as a power-law with slope $\beta=-0.73^{+0.16}_{-0.12}$, before dropping off rapidly at $R_o\approx0.4$...Comment: 17 pages, 15 figures, Accepted by Ap

PRIVATE SAVINGS IN TRANSITION ECONOMIES: ARE THERE TERMS OF TRADE SHOCKS?

The paper examines the impact of terms of trade shocks on private savings in the transition economies after accounting for the effect of other determinants. Economic agents in the transition economies are subject to tight credit constraints which are more pronounced during bad state of nature. Thus, adverse shocks to commodity prices in the world market can force them to reduce savings by a larger amount than they would otherwise have. Empirical analysis using a dynamic panel model and data from twenty one transition economies confirm that most of the determinants of savings identified in the literature also apply to the transition economies. Favorable movements in both the permanent and transitory components of the terms of trade have a significant positive impact on private savings with transitory movements having a larger impact than the permanent component. This reflects the lack of access to foreign borrowing that many of the transition economies have faced during the last decade. Although the impact of terms of trade shocks are found to be asymmetric, the magnitude of the impact appears to be small. The results are robust for alternative estimators, determinants, and country groupings.http://deepblue.lib.umich.edu/bitstream/2027.42/39958/3/wp572.pd

Preserved emotional awareness of pain in a patient with extensive bilateral damage to the insula, anterior cingulate, and amygdala

Functional neuroimaging investigations of pain have discovered a reliable pattern of activation within limbic regions of a putative "pain matrix" that has been theorized to reflect the affective dimension of pain. To test this theory, we evaluated the experience of pain in a rare neurological patient with extensive bilateral lesions encompassing core limbic structures of the pain matrix, including the insula, anterior cingulate, and amygdala. Despite widespread damage to these regions, the patient's expression and experience of pain was intact, and at times excessive in nature. This finding was consistent across multiple pain measures including self-report, facial expression, vocalization, withdrawal reaction, and autonomic response. These results challenge the notion of a "pain matrix" and provide direct evidence that the insula, anterior cingulate, and amygdala are not necessary for feeling the suffering inherent to pain. The patient's heightened degree of pain affect further suggests that these regions may be more important for the regulation of pain rather than providing the decisive substrate for pain's conscious experience

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Revealing continuity and sustainability through isotope analysis on the A14 project, Cambridgeshire, UK

The A14 archaeological project was the largest commercial archaeological programme in the UK - spanning a 25 km stretch of rural Cambridgeshire, which included a pioneering and ambitious multi-isotope programme to examine crop, livestock and human remains. The resulting dataset spans the Bronze Age to medieval period, incorporating settlements spread across multiple landscape blocks. Our focus on the Iron Age, Roman and Anglo-Saxon periods reveals a remarkable continuity in agricultural practices, diet and provenance. This isotopic homogeneity suggests a persistence of local traditions despite macro-economic and socio-political shifts. Subtle variations within this pattern, however, offer unique insights into individuals who deviated from the norm, hinting at the growing influence of external connections and market economies on these past communities. This study underscores the value of integrating multi-isotope analysis in large-scale commercial archaeological projects, and the rich narrative that emerges from collaborative efforts between commercial and academic researchers