Redesigning the Warren Animal Shelter

The new shelter should incorporate improved natural lighting and ventilation, adequate space for laundry facilities and more space for the animals\u27 living and bathing needs. The design should consider how to prevent dogs from barking and disturbing one another while in the kennels. Increased storage is necessary for the animal shelter to contain the food and living amenities for the incoming animals

Sobre los inicios del coleccionismo y los museos de arte en la Argentina

En la Argentina del siglo XIX, la formación de importantes colecciones privadas de arte se dio con anterioridad a la fundación de los museos. Estas colecciones mediante donaciones o legados fueron la base de los museos de arte del país y contribuyeron a lo largo de su historia al crecimiento de sus patrimonios condicionando directamente el perfil de sus acervos. Este artículo indaga sobre el inicio de la práctica del coleccionismo de arte en la Argentina, reconstruyendo algunas de las selecciones y mecanismos utilizados por los coleccionistas a la hora de ejercer sus juicios de gusto para armar sus conjuntos de obras. Este proceso se estudia en relación con la creación y crecimiento del primer y más importante museo de arte del país, el Museo Nacional de Bellas Artes de Buenos Aires. Se analiza con detenimiento la labor de su mentor y primer director Eduardo Schiaffino y los modos en que sus opciones estéticas y los dispositivos utilizados para el crecimiento del patrimonio muchas veces se continuaron en las administraciones subsiguientes. Se examinan también los casos de algunos museos creados posteriormente en el interior del país, en los que también tuvo fuerte injerencia el coleccionismo privado, pero que desde su génesis plantearon un modelo distinto al ser altamente receptivos a las producciones de arte nacional

Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF

International audienceBackground & Aims: Acute-on-chronic liver failure (ACLF), which develops in patients with cirrhosis, is characterized by intense systemic inflammation and organ failure(s). Because systemic inflammation is energetically expensive, its metabolic costs may result in organ dysfunction/failure. Therefore, we aimed to analyze the blood metabolome in patients with cirrhosis, with and without ACLF.Methods: We performed untargeted metabolomics using liquid chromatography coupled to high-resolution mass spectrometry in serum from 650 patients with AD (acute decompensation of cirrhosis, without ACLF), 181 with ACLF, 43 with compensated cirrhosis, and 29 healthy individuals.Results: Of the 137 annotated metabolites identified, 100 were increased in patients with ACLF of any grade, relative to those with AD, and 38 comprised a distinctive blood metabolite fingerprint for ACLF. Among patients with ACLF, the intensity of the fingerprint increased across ACLF grades, and was similar in patients with kidney failure and in those without, indicating that the fingerprint reflected not only decreased kidney excretion but also altered cell metabolism. The higher the ACLF-associated fingerprint intensity, the higher the plasma levels of inflammatory markers, tumor necrosis factor α, soluble CD206, and soluble CD163. ACLF was characterized by intense proteolysis and lipolysis; amino acid catabolism; extra-mitochondrial glucose metabolism through glycolysis, pentose phosphate, and D-glucuronate pathways; depressed mitochondrial ATP-producing fatty acid β-oxidation; and extra-mitochondrial amino acid metabolism giving rise to metabotoxins.Conclusions: In ACLF, intense systemic inflammation is associated with blood metabolite accumulation and profound alterations in major metabolic pathways, in particular inhibition of mitochondrial energy production, which may contribute to the development of organ failures.Lay summary: Acute-on-chronic liver failure (ACLF), which develops in patients with cirrhosis, is characterized by intense systemic inflammation and organ failure(s). Because systemic inflammation is energetically expensive, its metabolic costs may result in organ dysfunction/failure. We identified a 38-metabolite blood fingerprint specific for ACLF that revealed mitochondrial dysfunction in peripheral organs. This may contribute to organ failures

Habitat use in ducks breeding in boreal freshwater wetlands: a review

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