Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology

Dietary Restriction Depends on Nutrient Composition to Extend Chronological Lifespan in Budding Yeast Saccharomyces cerevisiae

10.1371/journal.pone.0064448PLoS ONE85

Influences of organizational investments in social capital on service employee commitment and performance

a b s t r a c t a r t i c l e i n f o Improving customers' service experiences by identifying ways to develop organizational cultures that better motivate and engage service employees is an important issue for service organizations and a top priority in services research. However, extant services research focuses far more on managing customer relationships than on the dynamics of effectively supporting and developing the service personnel who interact with customers. This study assesses the influence of an organizational human resource developmental initiative on service employees. The authors utilize social capital theory and the theory of reasoned action to propose and test a model that examines relationships between organizational investments in social capital and service employees' work-related attitudes, norms, and behaviors. Results from a field study of 407 customerfacing employees from multiple service organizations suggest that making organizational investments in social capital favorably influences service employees' commitment, job performance, and organizational citizenship behavior

Evaluation of Entrepreneurial-Innovative University Conditions and Activities from Students’ Point of View in the Context of Industry 4.0

19th International Symposium for Production Research, ISPR 2019 -- 28 August 2019 through 30 August 2019 -- 233539One of the issues frequently encountered in the digitalization of higher education is the transformation of universities to the University 4.0 with the Industry 4.0. University 4.0 refers to the characteristics that universities must have in the Industry 4.0 era. The adaptation of the workforce that will be most affected by the Industry 4.0 process and training it for the new competency needs will be carried out by universities and research centers to a great extent. The evaluation of the studies to be carried out within this framework in a wide range, not only in the fields of engineering but also in the fields of social sciences, medicine and even law, will accelerate the integration process of the Industry 4.0 at universities. In this way, with the change of the objectives and learning outcomes of the academic programs developed based on competency, it is naturally expected that the industry will have an impact on the educational programs and techniques. As a requirement of competition, state authorities care about the role of universities in entrepreneurship and have serious expectations. Public authorities support and promote universities in this area significantly. It is observed that universities have recently put forward their entrepreneurial and innovative university feature in marketing activities. However, how much are the students who are the real target group of the universities taken into consideration in the university entrepreneurship ecosystem? The questions such as “How can a university be measured and assessed as an entrepreneurial-innovative university?” have become a subject to be studied in the field of higher education. While looking for answers to these questions, evaluation of entrepreneurial-innovative university conditions and activities from the university students’ point of view in the context of Industry 4.0 and University 4.0 emerged as an important requirement. The aim of this methodological study is to develop a tool to measure the internal environmental conditions and activities of the university students and entrepreneurial-innovative university based on Koyuncuoglu and Tekin (2019)’s Entrepreneurial University Model. For the study, a sample was used consisting of 528 students from Selçuk University Faculty of Economics and Administrative Sciences and Konya Technical University Faculty of Engineering and Natural Sciences, in Konya Province in Turkey. Content validity, construct validity and reliability studies were conducted at the stage of development of the Entrepreneurial-Innovative University Conditions Scale. Data were analyzed on the computer using SPSS and LISREL package programs. According to the results of the explanatory factor analysis (EFA), 31-item and three-dimensional Entrepreneurial-Innovative University Conditions Scale was developed. The Cronbach’s alpha coefficient of the scale was calculated as.95 and the explanatory percentage was calculated as 51.29%. As a result of confirmatory factor analysis (CFA), it was seen that the scale had good fit values (X2/df: 2.47, RMSEA:.075, CFI:.96, NNFI:.96). It was concluded that the scale developed in this research is a valid and reliable measurement tool that can be used to measure the internal environmental conditions and activities of the Entrepreneurial-Innovative universities. It can be said that the entrepreneurial-innovative university conditions scale will be important for the universities which want to improve their student-oriented entrepreneurial-innovative features, public authorities and for the entire economy in macro level. © 2020, Springer Nature Switzerland AG

Entrepreneurial Competences of University Students in the Digital Age: A Scale Development Study

19th International Symposium for Production Research, ISPR 2019 -- 28 August 2019 through 30 August 2019 -- 233539Advances in technology continue to affect our lives day by day. The new technological developments gaining momentum with the 4th Industrial Revolution have an impact on the working life, employment and unemployment in the 4th industrial revolution as in every industrial revolution. Every new technology that has emerged may adversely affect some sectors and business areas and cause unemployment. The ongoing industrial revolution is expected to contribute to the formation of new businesses and new jobs. This change necessitates the preparation of the individuals for the needs of the new age as well as the equipping of individuals for entrepreneurship activities. There is no doubt that the dynamos of the preparatory process will be universities. This situation increases the importance of monitoring the developments in entrepreneurship and innovation in the field of technology and in gaining competence in this field for university students. As a requirement of competition, state authorities care about the role of universities in entrepreneurship and have serious expectations. Public authorities support and promote the universities in this area significantly. The questions such as ‘‘How are the students, who are the main target groups of universities, taken into account in the university entrepreneurship ecosystem?’’ and ‘‘What is the impact of universities on students through training, incentives and support activities in the field of entrepreneurship?’’ have become a topic to be studied in the field of higher education. While looking for answers to these questions, determining entrepreneurial competences of university students has emerged as an important requirement. The aim of this methodological study is to develop a tool to measure the entrepreneurial competencies of university students based on Kailer’s Entrepreneurship Competence Model. For the study, a sample was used consisting of 415 students from Selcuk University Faculty of Economics and Administrative Sciences and Konya Technical University Faculty of Engineering and Natural Sciences in Konya, Turkey. Content validity, construct validity and reliability studies were conducted at the development stage of Entrepreneurial Competences Scale of Students. The Data were analyzed on the computer using SPSS and LISREL package programs. According to the results of EFA, 25-item and two-dimensional Entrepreneurial Competency Scale was developed. Cronbach’s alpha coefficient of the scale was calculated as.90 and the percentage of variance explanatory was measured as 42.28%. Subsequent CFA results showed that the scale had good fit values (X2/df: 2.39, RMSEA:.073, CFI:.94, NNFI:.94). It is concluded that the scale developed in this study is a valid and reliable measurement tool that can be used to measure the entrepreneurship competencies of university students. It can be stated that the Entrepreneurship Competence Scale of University Students will be important for the universities that want to improve their student-based entrepreneurial-innovative features, public athorities and for the whole economy at macro level. © 2020, Springer Nature Switzerland AG