Revisión de los estudios orientados a la medición de las capacidades tecnológicas por medio de la literatura patente. Propuesta de análisis estadístico y evaluación de la calidad de una base de datos en patentes

El desarrollo de los estudios estadísticos y bibliométricos de la literatura patente fueron iniciados en España por diversos autores, que luego consideraremos. Se revisan los criterios destinados a la creación de una base de datos denominada Recodificacion. SAV para el análisis y tratamiento estadístico de 13.913 patentes españolas depositadas en la Oficina Española de Patentes y Marcas (OEPM).The development of statistical and bibliometrics studies of patents literature were begun in Spain by various authors who will be considered later. Review has been carried out of the criteria for the creation of a database entitled Recodification. SAV for the analysis and statistical treatment of 13,913 Spanish patents deposited in the Spanish Patents and Trademarks Office

Tilting light's polarization plane to spatially separate the ultrafast nonlinear response of chiral molecules

Distinguishing between the left- and right-handed versions of a chiral molecule (enantiomers) is vital, but also inherently difficult. Traditional optical methods using elliptically/circularly polarized light rely on linear effects which arise beyond the electric-dipole approximation, posing major limitations for ultrafast spectroscopy. Here we show how to turn an ultrashort elliptical pulse into an efficient chiro-optical tool: by tilting its polarization plane towards its propagation direction. This forward tilt can be achieved by focusing the beam tightly, creating structured light which exhibits a nontrivial polarization pattern in space. Using state-of-the-art computational modelling, we show that our structured field realizes a near-field interferometer for efficient chiral recognition that separates the nonlinear optical response of left- and right-handed molecules in space. Our work provides a simple, yet highly efficient, way of spatially structuring the polarization of light to image molecular chirality, with extreme enantio-efficiency and on ultrafast time scales

Theoretical Study of Ultrafast Electron Dynamics in Amino Acids

Prompt ioiuzatiou of large biological molecules may mince ultra fast charge migration along the molecular skeleton, preceding any unclear rearrangement[1, 2]. This phenomenon lots been recently observed in the amino acid phenylalanine [3] in a two-color pump probe experiment, where the production of ionic fragments Was measured as a function of the time delay between the two pulses and charge fluctuations manifested as sub-4.5 fs oscillations in the quantum yield of a spcific doubly charged fragment. We present our latcst results in glycine, and compare with previous findings in pheitylalanine [3]. We seek to perform a systematic study including larger aminoncids such as tryptophan

Deep learning model for automated detection of efflorescence and its possible treatment in images of brick facades

One of the most common pathologies in exposed brick facades is efflorescence, which, although they often have a similar appearance, their effects and way of solving them can range from a one-off cleaning to a repair that involves adding or replacing the material. Therefore, the novel goal of this work is to verify whether it is possible to automate this task of distinguishing what type of intervention each brick needs. To do this, the methodology followed focuses on proposing, training and validating a deep convolutional neural network with the real-time end-to-end method that simultaneously predicts multiple bounding boxes and class probabilities for those boxes. For this, images of 765 building facades will be used, of which 392 were selected, proceeding to label 4704 bricks, resulting in that the model achieved a mAP maximum at epoch 100 with 0.894, which is therefore of interest for the creation of intervention maps

Distribution of melanopsin positive neurons in pigmented and albino mice: evidence for melanopsin interneurons in the mouse retina.

Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their distribution is slightly different: while in pigmented mice ipRGCs are more abundant in the temporal retina, in albinos the ipRGCs are more abundant in superior retina. In both strains, ipRGCs are located in the retinal periphery, in the areas of lower Brn3a(+)RGC density. Both strains also contain displaced ipRGCs (d-ipRGCs) in the inner nuclear layer (INL) that account for 14% of total ipRGCs in pigmented mice and 5% in albinos. Tracing from both superior colliculli shows that 98% (pigmented) and 97% (albino) of the total ipRGCs, become retrogradely labeled, while double immunodetection of melanopsin and Brn3a confirms that few ipRGCs express this transcription factor in mice. Rather surprisingly, application of a retrograde tracer to the optic nerve (ON) labels all ipRGCs, except for a sub-population of the d-ipRGCs (14% in pigmented and 28% in albino, respectively) and melanopsin positive cells residing in the ciliary marginal zone (CMZ) of the retina. In the CMZ, between 20% (pigmented) and 24% (albino) of the melanopsin positive cells are unlabeled by the tracer and we suggest that this may be because they fail to send an axon into the ON. As such, this study provides the first evidence for a population of melanopsin interneurons in the mammalian retina

Generated emotions by various types of games in physical education

El objetivo del presente estudio ha sido ahondar en el conocimiento de las emociones generadas a través de la práctica de diversos tipos de juegos, mediante la puesta en práctica de una propuesta diseñada a tal efecto. Más concretamente se ha tratado de conocer en qué medida, los juegos cooperativos y de oposición permiten el desarrollo emocional del alumnado en comparación con los juegos populares cooperativos y de oposición. Los participantes han sido un total de 50 alumnos y alumnas de sexto curso de Educación Primaria. El instrumento empleado ha sido el cuestionario sobre las percepciones socioemocionales de Gil-Madrona y Martínez (2016). Los resultados indican una gran similitud entre la utilización de los juegos cooperativos y juegos populares cooperativos. No obstante, los juegos populares de oposición producen mayores emociones positivas en el alumnado respecto a los juegos de oposición. El porcentaje de alumnado que se decanta por las emociones plancenteras es manifiestamente superior al de aquellos que se decantan por las displacenteras. Finalmente, se concluye que la propuesta utilizada es eficaz para producir emociones en los cuatro dominios de acción motriz objeto de estudioThe aim of this research has been to know which are the generated emotions through the practice of diverse kinds of games, through a proposal. Specifically, it is have been tried to know how cooperative and opposition games allow for the emotional development of the students with respect to traditional cooperative games and traditional opposition games. A total of 50 children of 6th grade took part in this work. The instrument used was the Gil-Madrona and Martinez's questionnaire (2016) about socio-emotional perceptions. The results indicate a similarity between using cooperative and traditional cooperative games. However, traditional opposition games produce greater positive emotions in students with respect to opposition games. Finally, it is concluded that the approach used is effective to produce emotions in the four motor domains studie

Effects of ergo-nutritional strategies on recovery in combat sports disciplines

In order to improve the recovery process in combat sports disciplines, ergo-nutritional strategies could be an effective option in training and competition. Some of these ergo-nutritional aids could improve performance but literature references are scarce, with controversial results regarding actual recovery effects. This systematic review aimed to examine which ergo-nutritional methods are most effective for assisting in the recovery process in combat sports, and to determine the appropriate training stimuli. This systematic review was carried out following the Preferred Reporting Items for Systematic Review (PRISMA) guidelines. A computerized search was performed in PubMed, Web of Science, the Cochrane Collaboration Database, Evidence Database, Evidence Based Medicine Search review, National Guidelines, EM-BASE, Scopus and Google Scholar system (from 1995 to April 30, 2021). The PICOS model was used to define inclusion and exclusion criteria. Out of 123 studies initially found, 18 met the eligibility criteria and were included in the review. Data from 367 athletes from different disciplines were examined. The evidence was grouped in 4 areas: oxidative stress, muscle and energy recovery, muscle repair, and metabolic acidosis. Evidence showed that vitamins, minerals, and some natural ergo-nutritional products are effective as antioxidants. Carbohydrates and protein determine the recovery effect. Sodium bicarbonate has a role as primary acidosis metabolic delayer. Accordingly, ergo-nutritional aids can help in the recovery process. Considering the effects outlined in the literature, more studies are needed to provide firm evidence. Para mejorar el proceso de recuperación en las disciplinas deportivas de combate, las estrategias ergo-nutricionales son una opción eficaz en el entrenamiento y la competición. Algunas de estas alternativas mejoran el rendimiento, pero actualmente existe una escasa bibliografía con resultados controvertidos relacionados con el efecto de recuperación. Esta revisión sistemática tuvo como objetivo determinar qué estrategias ergo-nutricionales son más efectivas en los procesos de recuperación. Se llevó a cabo siguiendo las pautas Preferred Reporting Items for Systematic Review (PRISMA). Se realizó una búsqueda computarizada en PubMed, Web of Science, Cochrane Collaboration Database, Evidence Database, Evidence Based Medicine Search review, National Guidelines, EM-BASE, Scopus y el sistema Google Scholar (desde 1995 hasta el 30 de abril de 2021). Se utilizó el modelo PICOS para definir los criterios de inclusión y exclusión. De los 123 estudios encontrados inicialmente, 18 cumplieron los criterios de elegibilidad y fueron incluidos. Se examinaron datos de 367 atletas de diferentes disciplinas. La evidencia se agrupó en 4 áreas: estrés oxidativo, recuperación muscular y energética, reparación muscular y acidosis metabólica. La evidencia mostró que las vitaminas, los minerales y algunos productos ergo-nutricionales naturales son eficaces como antioxidantes, los hidratos de carbono y las proteínas determinan su efecto recuperador y el bicarbonato de sodio es el principal retardador metabólico de la acidosis. Se destaca la importancia de aceptar un plan ergo-nutricional para mejorar el proceso de recuperación. A pesar de ello, y teniendo en cuenta los efectos descritos en la literatura, se necesitan más estudios para reforzar la evidencia actual

Changes in depression and suicidal ideation under severe lockdown restrictions during the first wave of the COVID-19 pandemic in Spain: a longitudinal study in the general population - RETRACTION

El texto del artículo original se encuentra disponible en http://hdl.handle.net/10486/70204

Proteins Encoded by the gerP Operon Are Localized to the Inner Coat in Bacillus cereus Spores and Are Dependent on GerPA and SafA for Assembly.

The germination of Bacillus spores is triggered by certain amino acids and sugar molecules which permeate the outermost layers of the spore to interact with receptor complexes that reside in the inner membrane. Previous studies have shown that mutations in the hexacistronic gerP locus reduce the rate of spore germination, with experimental evidence indicating that the defect stems from reduced permeability of the spore coat to germinant molecules. Here, we use the ellipsoid localization microscopy technique to reveal that all six Bacillus cereus GerP proteins share proximity with cortex-lytic enzymes within the inner coat. We also reveal that the GerPA protein alone can localize in the absence of all other GerP proteins and that it has an essential role for the localization of all other GerP proteins within the spore. Its essential role is also demonstrated to be dependent on SafA, but not CotE, for localization, which is consistent with an inner coat location. GerP-null spores are shown also to have reduced permeability to fluorescently labeled dextran molecules compared to wild-type spores. Overall, the results support the hypothesis that the GerP proteins have a structural role within the spore associated with coat permeability.IMPORTANCE The bacterial spore coat comprises a multilayered proteinaceous structure that influences the distribution, survival, and germination properties of spores in the environment. The results from the current study are significant since they increase our understanding of coat assembly and architecture while adding detail to existing models of germination. We demonstrate also that the ellipsoid localization microscopy (ELM) image analysis technique can be used as a novel tool to provide direct quantitative measurements of spore coat permeability. Progress in all of these areas should ultimately facilitate improved methods of spore control in a range of industrial, health care, and environmental sectors.1. Engineering and Physical Sciences Research Council Centre for Doctoral Training in Sensor Technologies and Applications (EP/L015889/1) 2. Cambridge Nehru Scholarship 3. Raymond and Beverly Sackler Foundation 4. MedImmun