101 research outputs found
STATISTICAL INFERENCE FOR GEOMETRIC PROCESS WITH THE GENERALIZED RAYLEIGH DISTRIBUTION
In the present paper, statistical inference problem is considered for the geometric process (GP) by assuming the distribution of the first arrival time is generalized Rayleigh with the parameters and . We use the maximum likelihood method for obtaining the ratio parameter of the GP and distributional parameters of the generalized Rayleigh distribution. By a series of Monte-Carlo simulations evaluated through the different samples of sizes small, moderate and large, we also compare the estimation performances of the maximum likelihood estimators with the other estimators available in the literature such as modified moment, modified L-moment, and modified least squares. Furthermore, we present two real-life dataset analyzes to show the modeling behavior of GP with generalized Rayleigh distribution
Flows and Decompositions of Games: Harmonic and Potential Games
In this paper we introduce a novel flow representation for finite games in
strategic form. This representation allows us to develop a canonical direct sum
decomposition of an arbitrary game into three components, which we refer to as
the potential, harmonic and nonstrategic components. We analyze natural classes
of games that are induced by this decomposition, and in particular, focus on
games with no harmonic component and games with no potential component. We show
that the first class corresponds to the well-known potential games. We refer to
the second class of games as harmonic games, and study the structural and
equilibrium properties of this new class of games. Intuitively, the potential
component of a game captures interactions that can equivalently be represented
as a common interest game, while the harmonic part represents the conflicts
between the interests of the players. We make this intuition precise, by
studying the properties of these two classes, and show that indeed they have
quite distinct and remarkable characteristics. For instance, while finite
potential games always have pure Nash equilibria, harmonic games generically
never do. Moreover, we show that the nonstrategic component does not affect the
equilibria of a game, but plays a fundamental role in their efficiency
properties, thus decoupling the location of equilibria and their payoff-related
properties. Exploiting the properties of the decomposition framework, we obtain
explicit expressions for the projections of games onto the subspaces of
potential and harmonic games. This enables an extension of the properties of
potential and harmonic games to "nearby" games. We exemplify this point by
showing that the set of approximate equilibria of an arbitrary game can be
characterized through the equilibria of its projection onto the set of
potential games
Separable and Low-Rank Continuous Games
In this paper, we study nonzero-sum separable games, which are continuous
games whose payoffs take a sum-of-products form. Included in this subclass are
all finite games and polynomial games. We investigate the structure of
equilibria in separable games. We show that these games admit finitely
supported Nash equilibria. Motivated by the bounds on the supports of mixed
equilibria in two-player finite games in terms of the ranks of the payoff
matrices, we define the notion of the rank of an n-player continuous game and
use this to provide bounds on the cardinality of the support of equilibrium
strategies. We present a general characterization theorem that states that a
continuous game has finite rank if and only if it is separable. Using our rank
results, we present an efficient algorithm for computing approximate equilibria
of two-player separable games with fixed strategy spaces in time polynomial in
the rank of the game
Structure of Extreme Correlated Equilibria: a Zero-Sum Example and its Implications
We exhibit the rich structure of the set of correlated equilibria by
analyzing the simplest of polynomial games: the mixed extension of matching
pennies. We show that while the correlated equilibrium set is convex and
compact, the structure of its extreme points can be quite complicated. In
finite games the ratio of extreme correlated to extreme Nash equilibria can be
greater than exponential in the size of the strategy spaces. In polynomial
games there can exist extreme correlated equilibria which are not finitely
supported; we construct a large family of examples using techniques from
ergodic theory. We show that in general the set of correlated equilibrium
distributions of a polynomial game cannot be described by conditions on
finitely many moments (means, covariances, etc.), in marked contrast to the set
of Nash equilibria which is always expressible in terms of finitely many
moments
Correlated Equilibria in Continuous Games: Characterization and Computation
We present several new characterizations of correlated equilibria in games
with continuous utility functions. These have the advantage of being more
computationally and analytically tractable than the standard definition in
terms of departure functions. We use these characterizations to construct
effective algorithms for approximating a single correlated equilibrium or the
entire set of correlated equilibria of a game with polynomial utility
functions.Comment: Games and Economic Behavior, In Press, Accepted Manuscript, Available
online 16 April 201
IL-6 mediated JAK/STAT3 signaling pathway in cancer patients with cachexia
CONCLUSION: STAT3 may be considered as a therapeutic target for cachectic patients with gastric, lung and breast cancer. Furthermore, IL-6 mediates STAT3 activation in cachectic gastric and breast cancer patients (Tab. 5, Fig. 2, Ref. 62)
Development and validation of new SSR markers from expressed regions in the garlic genome
Only a limited number of simple sequence repeat (SSR) markers is available for the genome of garlic (Allium sativum L.) despite the fact that SSR markers have become one of the most preferred DNA marker systems. To develop new SSR markers for the garlic genome, garlic expressed sequence tags (ESTs) at the publicly available GarlicEST database were screened for SSR motifs and a total of 132 SSR motifs were identified. Primer pairs were designed for 50 SSR motifs and 24 of these primer pairs were selected as SSR markers based on their consistent amplification patterns and polymorphisms. In addition, two SSR markers were developed from the sequences of garlic cDNA-AFLP fragments. The use of 26 EST-SSR markers for the assessment of genetic relationship was tested using 31 garlic genotypes. Twenty six EST-SSR markers amplified 130 polymorphic DNA fragments and the number of polymorphic alleles per SSR marker ranged from 2 to 13 with an average of 5 alleles. Observed heterozygosity and polymorphism information content (PIC) of the SSR markers were between 0.23 and 0.88, and 0.20 and 0.87, respectively. Twenty one out of the 31 garlic genotypes were analyzed in a previous study using AFLP markers and the garlic genotypes clustered together with AFLP markers were also grouped together with EST-SSR markers demonstrating high concordance between AFLP and EST-SSR marker systems and possible immediate application of EST-SSR markers for fingerprinting of garlic clones. EST-SSR markers could be used in genetic studies such as genetic mapping, association mapping, genetic diversity and comparison of the genomes of Allium species
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