The Effect of Graded Doses of Oral Trihexyphenidyl on Lumen Diameter of Mus Musculus Renal Kidney

Trihexyfenidyl is a class of anticholinergic drugs used, among others, to treat the symptoms of Parkinson’s disease and to control extrapyramidal disorders due to central nervous system drugs. However, the use of high dose trihexyfenidyl may cause renal impairment. Until now, the understanding of the pathologies of renal disorders due to trihexyfenidyl is unclear. This research was conducted to look at the histologic features and changes in the renal tubules associated with the doses used. This research was an  experimental study which used 36 mice (Mus musculus) and they were divided into 4 groups. Control group  was given a standard feed while the treatment group consisted of three groups were given a dose of trihexyphenidyl with 0.0208mg/20grBW/day, 0.0416mg/20grBW/day and 0.0624mg/20grBW/day for 14 days. The research was done on October-November 2016 at Pharmacology, Anatomy and Histology laboratory, Faculty of Medicine Universitas Airlangga. The results showed that the average proximal tubule diameter in control goup was  24.4±2.13μm, group 1 was  21.1± 2.98μm, group 2 was  16.2± 4.1μm, and group 3 was 11.5±0.79μm. In the treatment group, the diameter of the proximal tubule decreased in proportion to the dose administered. The smallest proximal tubular lumen diameter was seen in the highest dose-treated group

Esophageal foreign body removal using endoscopy in cat

A 10-months-old cross long hair cat named Casper with clinical symptom of vomiting mixed with slimy cat feed was referred to Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Bogor Agricultural University to endoscopy examination and therapy. The owner believed that Casper ate a 5 cm long sewing needle a few days earlier. The history and physical examination were examined at DNA Clinic with symptoms of lack of appetite and becoming quieter and calmer. Radiogram showed the needle was in thorax area with a vertical needle penetrating the esophageal wall. Removal of the needle and observation of the esophagus area were done using endoscopy under general anesthesia. Using endoscopy, it was known that the needle was swallowed along with the sewing thread with position of all needles penetrating the esophagus wall and leaving a small amount of thread on the lumen. The needle was pulled back to the esophageal lumen by pulling the remaining thread and then both needle and the thread were pulled back out using an alligator grasping forceps that used through working channel. Therapy given after endoscopy was antibiotics and anti-emetics

Efficacy of sacubitril/valsartan vs. enalapril at lower than target doses in heart failure with reduced ejection fraction: the PARADIGM-HF trial.

AimsIn this analysis, we utilized data from PARADIGM-HF to test the hypothesis that participants who exhibited any dose reduction during the trial would have similar benefits from lower doses of sacubitril/valsartan relative to lower doses of enalapril.Methods and resultsIn a post-hoc analysis from PARADIGM-HF, we characterized patients by whether they received the maximal dose (200 mg sacubitril/valsartan or 10 mg enalapril twice daily) throughout the trial or had any dose reduction to lower doses (100/50/0 mg sacubitril/valsartan or 5/2.5/0 mg enalapril twice daily). The treatment effect for the primary outcome was estimated, stratified by dose level using time-updated Cox regression models. In the two treatment arms, participants with a dose reduction (43% of those randomized to enalapril and 42% of those randomized to sacubitril/valsartan) had similar baseline characteristics and similar baseline predictors of the need for dose reduction. In a time-updated analysis, any dose reduction was associated with a higher subsequent risk of the primary event [hazard ratio (HR) 2.5, 95% confidence interval (CI) 2.2-2.7]. However, the treatment benefit of sacubitril/valsartan over enalapril following a dose reduction was similar (HR 0.80, 95% CI 0.70-0.93, P < 0.001) to that observed in patients who had not experienced any dose reduction (HR 0.79, 95% CI 0.71-0.88, P < 0.001).ConclusionsIn PARADIGM-HF, study medication dose reduction identified patients at higher risk of a major cardiovascular event. The magnitude of benefit for patients on lower doses of sacubitril/valsartan relative to those on lower doses of enalapril was similar to that of patients who remained on target doses of both drugs

Kasus swimmer syndrome pada seekor anak kucing

Swimmer syndrome merupakan kondisi gangguan muskuloskeletal kongenital yang dapat terjadi pada anak kucing yang menyebabkan kaki menjadi terbuka ke arah lateral dan menyebabkan postur seperti katak. Seekor anak kucing persia betina bernama NN berusia 2 minggu dibawa ke Klinik Hewan Pet Vet menunjukkan gejala klinis mengalami kesulitan berjalan dengan gerakan seperti berenang. Pemeriksaan fisik menunjukkan kucing memiliki flat chest sehingga pernafasan terlihat dangkal dan cepat. Anak kucing didiagnosa mengalami swimmer syndrome. Terapi yang dilakukan terhadap anak kucing yaitu dengan memakaikan alat penahan pada bagian dada yang berbentuk setengah lingkaran. Alat ini diikatkan melingkari bagian dada dan dikenakan setiap hari. Perkembangan yang cukup baik ditunjukkan setelah 7 hari, dimana NN mulai dapat mengangkat tubuh dan dapat berjalan secara normal. Penggunaan alat bantu sebagai terapi pada kasus ini tetap diteruskan karena pembentukan tulang bagian dada yang belum sempurna.Swimmer syndrome merupakan kondisi gangguan muskuloskeletal kongenital yang dapat terjadi pada anak kucing yang menyebabkan kaki menjadi terbuka ke arah lateral dan menyebabkan postur seperti katak. Seekor anak kucing persia betina bernama NN berusia 2 minggu dibawa ke Klinik Hewan Pet Vet menunjukkan gejala klinis mengalami kesulitan berjalan dengan gerakan seperti berenang. Pemeriksaan fisik menunjukkan kucing memiliki flat chest sehingga pernafasan terlihat dangkal dan cepat. Anak kucing didiagnosa mengalami swimmer syndrome. Terapi yang dilakukan terhadap anak kucing yaitu dengan memakaikan alat penahan pada bagian dada yang berbentuk setengah lingkaran. Alat ini diikatkan melingkari bagian dada dan dikenakan setiap hari. Perkembangan yang cukup baik ditunjukkan setelah 7 hari, dimana NN mulai dapat mengangkat tubuh dan dapat berjalan secara normal. Penggunaan alat bantu sebagai terapi pada kasus ini tetap diteruskan karena pembentukan tulang bagian dada yang belum sempurna

Forward ray tracing for image projection prediction and surface reconstruction in the evaluation of corneal topography systems

A forward ray tracing (FRT) model is presented to determine the exact image projection in a general corneal topography system. Consequently, the skew ray error in Placido-based topography is demonstrated. A quantitative analysis comparing FRT-based algorithms and Placido-based algorithms in reconstructing the front surface of the cornea shows that arc step algorithms are more sensitive to noise (imprecise). Furthermore, they are less accurate in determining corneal aberrations particularly the quadrafoil aberration. On the other hand, FRT-based algorithms are more accurate and more precise showing that point to point corneal topography is superior compared to its Placido-based counterpart

Measure-Based Inconsistency-Tolerant Maintenance of Database Integrity

[EN] To maintain integrity, constraint violations should be prevented or repaired. However, it may not be feasible to avoid inconsistency, or to repair all violations at once. Based on an abstract concept of violation measures, updates and repairs can be checked for keeping inconsistency bounded, such that integrity violations are guaranteed to never get out of control. This measure-based approach goes beyond conventional methods that are not meant to be applied in the presence of inconsistency. It also generalizes recently introduced concepts of inconsistency-tolerant integrity maintenance.Partially supported by FEDER and the Spanish grants TIN2009-14460-C03 and TIN2010-17139Decker, H. (2013). Measure-Based Inconsistency-Tolerant Maintenance of Database Integrity. Lecture Notes in Computer Science. 7693:149-173. https://doi.org/10.1007/978-3-642-36008-4_7S1491737693Abiteboul, S., Hull, R., Vianu, V.: Foundations of Databases. 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Plenum Press (1978)Curino, C., Moon, H., Deutsch, A., Zaniolo, C.: Update Rewriting and Integrity Constraint Maintenance in a Schema Evolution Support System: PRISM++. PVLDB 4, 117–128 (2010)Dawson, J.: The compactness of first-order logic: From Gödel to Lindström. History and Philosophy of Logic 14(1), 15–37 (1993)Decker, H.: The Range Form of Databases and Queries or: How to Avoid Floundering. In: Proc. 5th ÖGAI. Informatik-Fachberichte, vol. 208, pp. 114–123. Springer (1989)Decker, H.: Drawing Updates From Derivations. In: Kanellakis, P.C., Abiteboul, S. (eds.) ICDT 1990. LNCS, vol. 470, pp. 437–451. Springer, Heidelberg (1990)Decker, H.: Extending Inconsistency-Tolerant Integrity Checking by Semantic Query Optimization. In: Bhowmick, S.S., Küng, J., Wagner, R. (eds.) DEXA 2008. LNCS, vol. 5181, pp. 89–96. Springer, Heidelberg (2008)Decker, H.: Answers That Have Integrity. In: Schewe, K.-D., Thalheim, B. (eds.) SDKB 2010. LNCS, vol. 6834, pp. 54–72. Springer, Heidelberg (2011)Decker, H.: Causes of the Violation of Integrity Constraints for Supporting the Quality of Databases. In: Murgante, B., Gervasi, O., Iglesias, A., Taniar, D., Apduhan, B.O. (eds.) ICCSA 2011, Part V. LNCS, vol. 6786, pp. 283–292. Springer, Heidelberg (2011)Decker, H.: Inconsistency-tolerant Integrity Checking based on Inconsistency Metrics. In: König, A., Dengel, A., Hinkelmann, K., Kise, K., Howlett, R.J., Jain, L.C. (eds.) KES 2011, Part II. LNCS, vol. 6882, pp. 548–558. Springer, Heidelberg (2011)Decker, H.: Partial Repairs that Tolerate Inconsistency. In: Eder, J., Bielikova, M., Tjoa, A.M. (eds.) ADBIS 2011. LNCS, vol. 6909, pp. 389–400. Springer, Heidelberg (2011)Decker, H.: Consistent Explanations of Answers to Queries in Inconsistent Knowledge Bases. In: Roth-Berghofer, T., Tintarev, N., Leake, D. (eds.) Explanation-aware Computing, Proc. IJCAI 2011 Workshop ExaCt 2011, pp. 71–80 (2011), http://exact2011.workshop.hm/index.phpDecker, H., Martinenghi, D.: Classifying integrity checking methods with regard to inconsistency tolerance. In: Proc. PPDP 2008, pp. 195–204. ACM Press (2008)Decker, H., Martinenghi, D.: Modeling, Measuring and Monitoring the Quality of Information. In: Heuser, C.A., Pernul, G. (eds.) ER 2009. LNCS, vol. 5833, pp. 212–221. Springer, Heidelberg (2009)Decker, H., Martinenghi, D.: Inconsistency-tolerant Integrity Checking. IEEE TKDE 23(2), 218–234 (2011)Decker, H., Muñoz-Escoí, F.D.: Revisiting and Improving a Result on Integrity Preservation by Concurrent Transactions. In: Meersman, R., Dillon, T., Herrero, P. (eds.) OTM 2010 Workshops. LNCS, vol. 6428, pp. 297–306. Springer, Heidelberg (2010)Dung, P., Kowalski, R., Toni, F.: Dialectic Proof Procedures for Assumption-based Admissible Argumentation. Artificial Intelligence 170(2), 114–159 (2006)Ebbinghaus, H.-D., Flum, J.: Finite Model Theory, 2nd edn. Springer (2006)Embury, S., Brandt, S., Robinson, J., Sutherland, I., Bisby, F., Gray, A., Jones, A., White, R.: Adapting integrity enforcement techniques for data reconciliation. Information Systems 26, 657–689 (2001)Enderton, H.: A Mathematical Introduction to Logic, 2nd edn. Academic Press (2001)Eiter, T., Fink, M., Greco, G., Lembo, D.: Repair localization for query answering from inconsistent databases. ACM TODS 33(2), article 10 (2008)Furfaro, F., Greco, S., Molinaro, C.: A three-valued semantics for querying and repairing inconsistent databases. Ann. Math. Artif. Intell. 51(2-4), 167–193 (2007)Grant, J., Hunter, A.: Measuring the Good and the Bad in Inconsistent Information. In: Proc. 22nd IJCAI, pp. 2632–2637 (2011)Greco, G., Greco, S., Zumpano, E.: A logical framework for querying and repairing inconsistent databases. 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AAAI Press (2008)Hunter, A., Konieczny, S.: On the measure of conflicts: Shapley Inconsistency Values. Artificial Intelligence 174, 1007–1026 (2010)Kakas, A., Mancarella, P.: Database updates through abduction. In: Proc. 16th VLDB, pp. 650–661. Morgan Kaufmann (1990)Kakas, A., Kowalski, R., Toni, F.: The role of Abduction in Logic Programming. In: Gabbay, D., Hogger, C., Robinson, J.A. (eds.) Handbook of Logic in Artificial Intelligence and Logic Programming, vol. 5, pp. 235–324. Oxford University Press (1998)Lee, S.Y., Ling, T.W.: Further improvements on integrity constraint checking for stratifiable deductive databases. In: Proc. VLDB 1996, pp. 495–505. Morgan Kaufmann (1996)Lehrer, K.: Relevant Deduction and Minimally Inconsistent Sets. Journal of Philosophy 3(2,3), 153–165 (1973)Mu, K., Liu, W., Jin, Z., Bell, D.: A Syntax-based Approach to Measuring the Degree of Inconsistency for Belief Bases. J. Approx. Reasoning 52(7), 978–999 (2011)Lloyd, J., Sonenberg, L., Topor, R.: Integrity constraint checking in stratified databases. J. Logic Programming 4(4), 331–343 (1987)Lozinskii, E.: Resolving contradictions: A plausible semantics for inconsistent systems. J. Automated Reasoning 12(1), 1–31 (1994)Ma, Y., Qi, G., Hitzler, P.: Computing inconsistency measure based on paraconsistent semantics. J. Logic Computation 21(6), 1257–1281 (2011)Martinenghi, D., Christiansen, H.: Transaction Management with Integrity Checking. In: Andersen, K.V., Debenham, J., Wagner, R. (eds.) DEXA 2005. LNCS, vol. 3588, pp. 606–615. Springer, Heidelberg (2005)Martinenghi, D., Christiansen, H., Decker, H.: Integrity Checking and Maintenance in Relational and Deductive Databases and Beyond. In: Ma, Z. (ed.) Intelligent Databases: Technologies and Applications, pp. 238–285. IGI Global (2006)Martinez, M.V., Pugliese, A., Simari, G.I., Subrahmanian, V.S., Prade, H.: How Dirty Is Your Relational Database? An Axiomatic Approach. In: Mellouli, K. (ed.) ECSQARU 2007. LNCS (LNAI), vol. 4724, pp. 103–114. Springer, Heidelberg (2007)Meyer, J., Wieringa, R. (eds.): Deontic Logic in Computer Science. Wiley (1994)Nicolas, J.M.: Logic for improving integrity checking in relational data bases. Acta Informatica 18, 227–253 (1982)Plexousakis, D., Mylopoulos, J.: Accommodating Integrity Constraints During Database Design. In: Apers, P.M.G., Bouzeghoub, M., Gardarin, G. (eds.) EDBT 1996. LNCS, vol. 1057, pp. 495–513. Springer, Heidelberg (1996)Rahm, E., Do, H.: Data Cleaning: Problems and Current Approaches. Data Engineering Bulletin 23(4), 3–13 (2000)Sadri, F., Kowalski, R.: A theorem-proving approach to database integrity. In: Minker, J. (ed.) Foundations of Deductive Databases and Logic Programming, pp. 313–362. Morgan Kaufmann (1988)Thimm, M.: Measuring Inconsistency in Probabilistic Knowledge Bases. In: Proc. 25th UAI, pp. 530–537. 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Prevalence, molecular markers, and outcome of bronchial squamous carcinoma in situ in high-risk subjects

Publisher Copyright: © 2023 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology. © 2023 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.Bronchial squamous carcinoma in situ (CIS) is a preinvasive lesion that is thought to precede invasive carcinoma. We conducted prospective autofluorescence and white light bronchoscopy trials between 1992 and 2016 to assess the prevalence, molecular markers, and outcome of individuals with CIS and other preneoplastic bronchial lesions. Biopsies were evaluated at multiple levels and selected biopsies were tested for aneuploidy and DNA sequenced for TP53 mutation. Thirty-one individuals with CIS were identified. Twenty-two cases of CIS occurred in association with concurrent invasive carcinomas. Seven of the invasive tumors were radiographically occult. In two cases, CIS spread from the focus of invasive carcinoma into contralateral lung lobes, forming secondary invasive tumors. In nine cases, CIS occurred as isolated lesions and one progressed to invasive squamous carcinoma at the same site 40 months after discovery. In a second case, CIS was a precursor of carcinoma at a separate site in a different lobe. In seven cases CIS regressed to a lower grade or disappeared. High level chromosomal aneusomy was often associated with TP53 mutation and with invasive carcinoma. CIS most often occurs in association with invasive squamous carcinoma and may extend along the airways into distant lobes. In rare cases, CIS may be observed to directly transform into invasive carcinoma. CIS may be indicative of invasive tumor at a separate distant site. Isolated CIS may regress. Molecular changes parallel histological changes in CIS and may be used to map clonal expansion in the airways.Peer reviewe

Refolding by High Pressure of a Toxin Containing Seven Disulfide Bonds: Bothropstoxin-1 from Bothrops jararacussu

Aggregation is a serious obstacle for recovery of biologically active heterologous proteins from inclusion bodies (IBs) produced by recombinant bacteria. E. coli transformed with a vector containing the cDNA for Bothropstoxin-1 (BthTx-1) expressed the recombinant product as IBs. In order to obtain the native toxin, insoluble and aggregated protein was refolded using high hydrostatic pressure (HHP). IBs were dissolved and refolded (2 kbar, 16 h), and the effects of protein concentration, as well as changes in ratio and concentration of oxido-shuffling reagents, guanidine hydrochloride (GdnHCl), and pH in the refolding buffer, were assayed. A 32% yield (7.6 mg per liter of bacterial culture) in refolding of the native BthTx-1 was obtained using optimal conditions of the refolding buffer (Tris–HCl buffer, pH 7.5, containing 3 mM of a 2:3 ratio of GSH/GSSG, and 1 M GdnHCl). Scanning electron microscopy (SEM) showed that that disaggregation of part of IBs particles occurred upon compression and that the morphology of the remaining IBs, spherical particles, was not substantially altered. Dose-dependent cytotoxic activity of high-pressure refolded BthTx-1 was shown in C2C12 muscle cells