226 research outputs found

    COMPORTAMIENTO DEL INTERVALO QT CORREGIDO EN ARTRITIS TEMPRANA

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    Introducción: La  dispersión del  intervalo QT  ha sido descripta en  pacientes con artritis reumatoidea (AR) y  puede ser un marcador útil de morbi-mortalidad cardiovascular.Objetivos: Conocer el comportamiento del intervalo QT corregido (iQTc) en pacientes con AT y evaluar la asociación con  actividad de la enfermedad (AE).Material y Métodos:  Se realizó un estudio comparativo de corte transversal que incluyó pacientes mayores de 16 años, con diagnóstico de artritis temprana (AT) , atendidos en la  Unidad de Reumatología del Hospital Córdoba, desde enero de 2010 a diciembre de 2013. El grupo control se apareó por edad, sexo y antecedentes patológicos.  Los criterios de exclusión fueron evidencias  de IAM,  arritmia, potasemia&gt;5mEq/L,  ingesta de fármacos que afecten el QT. Se recolectaron datos demográficos, la actividad de la enfermedad se midió por DiseaseActivity Score (DAS 28), clasificando la actividad de la enfermedad en Baja AE, DAS 28 menor a 3,2,  Moderada/ Alta mayor de 3.2;   y se realizó ECG con técnica  estándar. El  intervalo QT fue medido desde el comienzo del complejo QRS hasta el final de la onda T. Para obtener el valor del iQTc, se utilizó la fórmula de Bazett.Resultados: El número de pacientes fue de 31, 83.9 % de sexo femenino y con edad media de 41.9 años, el DAS 28 promedio de 5.09. El grupo control incluyo 31 individuos con  una edad media de 42.2. El intervalo QT fue de 0.376 mm/s y el iQTc de 0.408 en AT y el QT fue de 0.381 mm/s y el iQTc de 0.415mm/s en el grupo control (p NS, p NS). El QT y el iQTc fueron de 0.39 y 0.38mm/s en los pacientes con baja  AE; 0.37mm/s y 0.411en Moderada / Alta AE (p=NS).Conclusión: El iQTc no demostró alteraciones ni se relacionó con actividad de la enfermedad en  AT   Background: The QT interval modification has been described in patients with Rheumatoid Arthritis (RA) and it could be a useful marker of cardiovascular morbidity and mortality.Aims: To evaluate the QT interval modifications in patients with early arthritis (EA) and its association with disease activity (DA).METHODS: We studied patients with diagnosis of EA attended to Rheumatology Unit at Córdoba Hospital from January 2010 to December 2013. Control group was population age, gender and cardiovascular risk factors matched. Exclusion criteria were: myocardial infarction, arrhythmia, K level &gt;5, or anti-arrhythmia treatment. ECG was performed by standard technique and QT interval was measured from the beginning of QRS to the end of T wave. QTC value was calculated by Bazzet formula.  The activity disease was measured by Disease Activity Score (DAS 28), and was considered low disease activity below 3.2, and moderate / high disease activity more than 3,2.RESULTS: 31 patients were included with 83.9 % of females and the mean age was  41.9 years old and DAS 28 was 5.09.  31 persons were included as a control group with a mean age of 42.2 years old.  QT interval was  0.376 mm/s  and l QTC  0.408  in EA and  QT was  0.381 mm/s and  QTC  0.415 mm/s  in the control group ( p= NS, p= NS).  QT interval and  QTC were  0.39 and 0.38 in low DA patients; 0.37 and  0.411 in Moderate / High DA ( p=NS)CONCLUSIONS: The QT interval  was not modified and it was not related with DA in EA. </p

    Dimensional analysis of soil properties after treatment with the rotary paraplow, a new conservationist tillage tool

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    This study examined a new conservation tillage tool, the "rotary paraplow". Emphasis was placed on evaluating the tool's conservation potential using dimensionless graph analysis. The dynamic conditions of the soil were investigated in terms of physical soil properties. Having determined the variables to be measured, dimensional analysis was used to plan the experiments. Two variations were considered for each dependent variable (linear speed, working depth, and rotation velocity), totaling eight treatments, allotting in each an experimental strip with five data collection points. This arrangement totaled 16 experimental strips, with 80 data collection points for all variables. The rotary paraplow generates a trapezoidal furrow for planting with a very wide bottom and narrower at the top. The volumetric subsoiling action generates cracks on the sides of the band. Because of their specific geometry the blades of rotary paraplow generate a soil failure according to its natural crack angle, optimizing the energy use, while preserving the natural soil properties. Results showed the conservation character of the rotary paraplow, capable of breaking up clods for planting without changing the original physical soil properties.93693701FINE

    Agricultural machinery adequacy for handling the mombaça grass biomass in agroforestry systems.

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    Abstract: The current scenario of Agroforestry Systems (AFS) worldwide lacks specific machinery, resulting in practically all operations being carried out manually. This leads to a significant physical effort for small-scale farmers and limits the implementation of AFS to small areas. The objective of the study was to evaluate the suitability of existing machines for performing agroforestry tasks. This research utilizes Descriptive Statistics and Exponentially Weighted Moving Average methods to evaluate the data and compare the treatments, where different machines are used to cut Mombaça grass (Megathyrsus maximus Jacq): (i) costal brushcutter (CBC); (ii) tractor-mounted rotary brushcutter (RBC); and (iii) mini grain reaper machine (GRM). The experiments were conducted in Jaguariúna, São Paulo, Brazil. GRM is recommended for achieving greater biomass production, reducing raking time, and minimizing operational costs. CBC is suitable for smaller areas due to its affordability and slow operation, which requires significant physical effort. RBC is recommended for reducing working time, physical effort, and personnel costs, making it suitable for larger-scale contexts

    Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

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    Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p&lt;0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p&lt;0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding

    Phenolic compounds and antioxidant, antimicrobial and antimycobacterial activities of Serjania erecta Radlk. (Sapindaceae)

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    Serjania erecta Radlk.(Sapindaceae) is a medicinal plant traditionally used in Brazil. We assayed the ethanolic extract of leaves and roots against seven microorganisms. The REMA (Resazurin Microtiter Assay) assay was used to measure the biological activity in vitro against Mycobacterium tuberculosis and our results showed moderate activity of the ethanolic extract. On the other hand S. aureus, P. aeruginosa, S. setubal, C. albicans, S. cerevisiae and E. coli revealed that the leaves and roots of S. erecta inhibited the growth of all microorganisms. The ethanolic extracts of leaves and roots showed low values of antioxidant activities. The ethanolic extracts of leaves and roots were analyzed by chromatographic and spectrometric methods. (-)-Epicatechin, kaempferol aglycone and five glycoside derivates were isolated: kaempferol-3-O-α-L-rhamnopyranoside, kaempferol-3-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside from the roots and kaempferol, kaempferol 3,7-di-O-α-L-rhamnopyranoside, vitexin, isovitexin and (-)-epicatechin in the leaves. This is the first chemical study reported in the literature about this specie
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