Scottish theme towns: have new identities enhanced development?

Three small towns in southwest Scotland have recently been branded as distinct theme towns, based on books, artists and food. This is an attempt to make them more attractive to visitors and thereby improve their economy. The objective of this research is to establish whether the new identities possessed by the towns have enhanced their development. It is argued, using data reviewing the past decade, that they have all developed, albeit at different rates, in terms of the economy and culture. Moreover, it is maintained that social capital has been enhanced and is a factor whose importance has been under-appreciated by planners and observers of this type of process. The relevance of the new identity to the pre-branding identity is also seen as a factor in successful development and ideas of authenticity and heritage are brought to bear on the relationship

The distance to the Vela pulsar gauged with HST parallax oservations

The distance to the Vela pulsar (PSR B0833-45) has been traditionally assumed to be 500 pc. Although affected by a significant uncertainty, this value stuck to both the pulsar and the SNR. In an effort to obtain a model free distance measurement, we have applied high resolution astrometry to the pulsar V~23.6 optical counterpart. Using a set of five HST/WFPC2 observations, we have obtained the first optical measurement of the annual parallax of the Vela pulsar. The parallax turns out to be 3.4 +/- 0.7 mas, implying a distance of 294(-50;+76) pc, i.e. a value significantly lower than previously believed. This affects the estimate of the pulsar absolute luminosity and of its emission efficiency at various wavelengths and confirms the exceptionally high value of the N_e towards the Vela pulsar. Finally, the complete parallax data base allows for a better measurement of the Vela pulsar proper motion (mu_alpha(cos(delta))=-37.2 +/- 1.2 mas/yr; mu_delta=28.2 +/- 1.3 mas/yr after correcting for the peculiar motion of the Sun) which, at the parallax distance, implies a transverse velocity of ~65 km/s. Moreover, the proper motion position angle appears specially well aligned with the axis of symmetry of the X-ray nebula as seen by Chandra. Such an alignment allows to assess the space velocity of the Vela pulsar to be ~81 km/s.Comment: LaTeX, 21 pages, 5 figures. Accepted for publication in Ap

Tracking pulsar dispersion measures using the GMRT

In this paper, we describe a novel experiment for the accurate estimation of pulsar dispersion measures using the Giant Metre-wave Radio Telescope. This experiment was carried out for a sample of twelve pulsars, over a period of more than one year (January 2001 to May 2002) with observations about once every fortnight. At each epoch, the pulsar DMs were obtained from simultaneous dual frequency observations, without requiring any absolute timing information. The DM estimates were obtained from both the single pulse data streams and from the average profiles. The accuracy of the DM estimates at each epoch is ~ 1 part in 10^4 or better, making the data set useful for many different kinds of studies. The time series of DM shows significant variations on time scales of weeks to months for most of the pulsars. A comparison of the mean DM values from these data show significant deviations from catalog values (as well as from other estimates in literature) for some of the pulsars, with PSR B1642-03 showing the most notable changes. From our analysis results it appears that constancy of pulsar DMs (at the level of 1 in 10^3 or better) can not be taken for granted. For PSR B2217+47, we see evidence for a large-scale DM gradient over a one year period, which is modeled as being due to a blob of enhanced electron density sampled by the line of sight. For some pulsars, including pulsars with fairly simple profiles like PSR B1642-03, we find evidence for small changes in DM values for different frequency pairs of measurement, a result that needs to be investigated in detail. Another interesting result is that we find significant differences in DM values obtained from average profiles and single pulse data.Comment: 10 pages, 7 Postscript figures, to be published in MNRA

Light curves of hydrogen-poor Superluminous Supernovae from the Palomar Transient Factory

We investigate the light-curve properties of a sample of 26 spectroscopically confirmed hydrogen-poor superluminous supernovae (SLSNe-I) in the Palomar Transient Factory (PTF) survey. These events are brighter than SNe Ib/c and SNe Ic-BL, on average, by about 4 and 2~mag, respectively. The peak absolute magnitudes of SLSNe-I in rest-frame $g$ band span $-22\lesssim M_g \lesssim-20$~mag, and these peaks are not powered by radioactive $^{56}$Ni, unless strong asymmetries are at play. The rise timescales are longer for SLSNe than for normal SNe Ib/c, by roughly 10 days, for events with similar decay times. Thus, SLSNe-I can be considered as a separate population based on photometric properties. After peak, SLSNe-I decay with a wide range of slopes, with no obvious gap between rapidly declining and slowly declining events. The latter events show more irregularities (bumps) in the light curves at all times. At late times, the SLSN-I light curves slow down and cluster around the $^{56}$Co radioactive decay rate. Powering the late-time light curves with radioactive decay would require between 1 and 10${\rm M}_\odot$ of Ni masses. Alternatively, a simple magnetar model can reasonably fit the majority of SLSNe-I light curves, with four exceptions, and can mimic the radioactive decay of $^{56}$Co, up to $\sim400$ days from explosion. The resulting spin values do not correlate with the host-galaxy metallicities. Finally, the analysis of our sample cannot strengthen the case for using SLSNe-I for cosmology.Comment: 120 pages, 48 figures, 78 tables. ApJ in pres

Vegetation plays an important role in mediating future water resources

Future environmental change is expected to modify the global hydrological cycle, with consequences for the regional distribution of freshwater supplies. Regional precipitation projections, however, differ largely between models, making future water resource projections highly uncertain. Using two representative concentration pathways and nine climate models, we estimate 21st century water resources across Australia, employing both a process-based dynamic vegetation model and a simple hydrological framework commonly used in water resource studies to separate the effects of climate and vegetation on water resources. We show surprisingly robust, pathway-independent regional patterns of change in water resources despite large uncertainties in precipitation projections. Increasing plant water use efficiency (due to the changing atmospheric CO2) and reduced green vegetation cover (due to the changing climate) relieve pressure on water resources for the highly populated, humid coastal regions of eastern Australia. By contrast, in semi-arid regions across Australia, runoff declines are amplified by CO2-induced greening, which leads to increased vegetation water use. These findings highlight the importance of including vegetation dynamics in future water resource projections

Immunomagnetic t-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody

Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (0×19) bound to monosized, magnetic, polymer beads, T lymphocytes were removed in vitro from normal bone marrow. The removal of the T lymphocytes was confirmed by flow cytometry. Injection of the T-lymphocyte-depleted bone marrow into fully allogeneic rats prevents the induction of GVHD and prolongs host survival. A highly efficient technique of T-lymphocyte depletion using rat bone marrow is described. It involves the binding of OX-19, a MoAb directed against all rat thy-mocytes and mature peripheral T lymphocytes, to monosized, magnetic polymer spheres. Magnetic separation of T lymphocytes after mixing the allogeneic bone marrow with the bead/OX-19 complex provides for a simple, rapid depletion of T lymphocytes from the bone marrow. In vitro studies using flow cytometry and the prevention of GVHD in a fully allogeneic rat bone marrow model have been used to demonstrate the effectiveness of the depletion procedure. © 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted

The effects of CO2, climate and land-use on terrestrial carbon balance, 1920-1992: An analysis with four process-based ecosystem models

The concurrent effects of increasing atmospheric CO2 concentration, climate variability, and cropland establishment and abandonment on terrestrial carbon storage between 1920 and 1992 were assessed using a standard simulation protocol with four process-based terrestrial biosphere models. Over the long-term(1920–1992), the simulations yielded a time history of terrestrial uptake that is consistent (within the uncertainty) with a long-term analysis based on ice core and atmospheric CO2 data. Up to 1958, three of four analyses indicated a net release of carbon from terrestrial ecosystems to the atmosphere caused by cropland establishment. After 1958, all analyses indicate a net uptake of carbon by terrestrial ecosystems, primarily because of the physiological effects of rapidly rising atmospheric CO2. During the 1980s the simulations indicate that terrestrial ecosystems stored between 0.3 and 1.5 Pg C yr−1, which is within the uncertainty of analysis based on CO2 and O2 budgets. Three of the four models indicated (in accordance with O2 evidence) that the tropics were approximately neutral while a net sink existed in ecosystems north of the tropics. Although all of the models agree that the long-term effect of climate on carbon storage has been small relative to the effects of increasing atmospheric CO2 and land use, the models disagree as to whether climate variability and change in the twentieth century has promoted carbon storage or release. Simulated interannual variability from 1958 generally reproduced the El Niño/Southern Oscillation (ENSO)-scale variability in the atmospheric CO2 increase, but there were substantial differences in the magnitude of interannual variability simulated by the models. The analysis of the ability of the models to simulate the changing amplitude of the seasonal cycle of atmospheric CO2 suggested that the observed trend may be a consequence of CO2 effects, climate variability, land use changes, or a combination of these effects. The next steps for improving the process-based simulation of historical terrestrial carbon include (1) the transfer of insight gained from stand-level process studies to improve the sensitivity of simulated carbon storage responses to changes in CO2 and climate, (2) improvements in the data sets used to drive the models so that they incorporate the timing, extent, and types of major disturbances, (3) the enhancement of the models so that they consider major crop types and management schemes, (4) development of data sets that identify the spatial extent of major crop types and management schemes through time, and (5) the consideration of the effects of anthropogenic nitrogen deposition. The evaluation of the performance of the models in the context of a more complete consideration of the factors influencing historical terrestrial carbon dynamics is important for reducing uncertainties in representing the role of terrestrial ecosystems in future projections of the Earth system

Use of a formal consensus development technique to produce recommendations for improving the effectiveness of adult mental health multidisciplinary team meetings

This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Multidisciplinary team (MDT) meetings are the core mechanism for delivering mental health care but it is unclear which models improve care quality. The aim of the study was to agree recommendations for improving the effectiveness of adult mental health MDT meetings, based on national guidance, research evidence and experiential insights from mental health and other medical specialties. METHODS: We established an expert panel of 16 health care professionals, policy-makers and patient representatives. Five panellists had experience in a range of adult mental health services, five in heart failure services and six in cancer services. Panellists privately rated 68 potential recommendations on a scale of one to nine, and re-rated them after panel discussion using the RAND/UCLA Appropriateness Method to determine consensus. RESULTS: We obtained agreement (median ≥ 7) and low variation in extent of agreement (Mean Absolute Deviation from Median of ≤1.11) for 21 recommendations. These included the explicit agreement and auditing of MDT meeting objectives, and the documentation and monitoring of treatment plan implementation. CONCLUSIONS: Formal consensus development methods that involved learning across specialities led to feasible recommendations for improved MDT meeting effectiveness in a wide range of settings. Our findings may be used by adult mental health teams to reflect on their practice and facilitate improvement. In some other contexts, the recommendations will require modification. For example, in Child and Adolescent Mental Health Services, context-specific issues such as the role of carers should be taken into account. A limitation of the comparative approach adopted was that only five members of the panel of 16 experts were mental health specialists.This report presents independent research commissioned by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, MRC, CCF, NETSCC, the Health Services and Delivery Research programme or the Department of Health

Interleukin 7 from Maternal Milk Crosses the Intestinal Barrier and Modulates T- Cell Development in Offspring

Background Breastfeeding protects against illnesses and death in hazardous environments, an effect partly mediated by improved immune function. One hypothesis suggests that factors within milk supplement the inadequate immune response of the offspring, but this has not been able to account for a series of observations showing that factors within maternally derived milk may supplement the development of the immune system through a direct effect on the primary lymphoid organs. In a previous human study we reported evidence suggesting a link between IL-7 in breast milk and the thymic output of infants. Here we report evidence in mice of direct action of maternally-derived IL-7 on T cell development in the offspring. Methods and Findings  We have used recombinant IL-7 labelled with a fluorescent dye to trace the movement in live mice of IL-7 from the stomach across the gut and into the lymphoid tissues. To validate the functional ability of maternally derived IL- 7 we cross fostered IL-7 knock-out mice onto normal wild type mothers. Subsets of thymocytes and populations of peripheral T cells were significantly higher than those found in knock-out mice receiving milk from IL-7 knock-out mothers. Conclusions/Significance Our study provides direct evidence that interleukin 7, a factor which is critical in the development of T lymphocytes, when maternally derived can transfer across the intestine of the offspring, increase T cell production in the thymus and support the survival of T cells in the peripheral secondary lymphoid tissue