494 research outputs found

    The Generalised Liar Paradox: A Quantum Model and Interpretation

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    The formalism of abstracted quantum mechanics is applied in a model of the generalized Liar Paradox. Here, the Liar Paradox, a consistently testable configuration of logical truth properties, is considered a dynamic conceptual entity in the cognitive sphere. Basically, the intrinsic contextuality of the truth-value of the Liar Paradox is appropriately covered by the abstracted quantum mechanical approach. The formal details of the model are explicited here for the generalized case. We prove the possibility of constructing a quantum model of the m-sentence generalizations of the Liar Paradox. This includes (i) the truth-falsehood state of the m-Liar Paradox can be represented by an embedded 2m-dimensional quantum vector in a (2m)^m dimensional complex Hilbert space, with cognitive interactions corresponding to projections, (ii) the construction of a continuous 'time' dynamics is possible: typical truth and falsehood value oscillations are described by Schrodinger evolution, (iii) Kirchoff and von Neumann axioms are satisfied by introduction of 'truth-value by inference' projectors, (iv) time invariance of unmeasured state.Comment: 13 pages, to be published in Foundations of Scienc

    Somatic Genomic Variations in Early Human Prenatal Development

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    Only 25 to 30% of conceptions result in a live birth. There is mounting evidence that the cause for this low fecundity is an extremely high incidence of chromosomal rearrangements occurring in the cleavage stage embryo. In this review, we gather all recent evidence for an extraordinary degree of mosaicisms in early embryogenesis. The presence of the rearrangements seen in the cleavage stage embryos can explain the origins of the placental mosaicisms seen during chorion villi sampling as well as the chromosomal anomalies seen in early miscarriages. Whereas these rearrangements often lead to implantation failure and early miscarriages, natural selection of the fittest cells in the embryo is the likely mechanism leading to healthy fetuses

    How to play two-players restricted quantum games with 10 cards

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    We show that it is perfectly possible to play 'restricted' two-players, two-strategies quantum games proposed originally by Marinatto and Weber having as the only equipment a pack of 10 cards. The 'quantum board' of such a model of these quantum games is an extreme simplification of 'macroscopic quantum machines' proposed by one of the authors in numerous papers that allow to simulate by macroscopic means various experiments performed on two entangled quantum objectsComment: 4 pages, 3 figure

    Biosimilar recombinant follitropin alfa preparations versus the reference product (Gonal-FÂŽ) in couples undergoing assisted reproductive technology treatment : a systematic review and meta-analysis

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    Acknowledgments Authors would like to thank Dr. Rui Wang (Department of Obstetrics and Gynecology, University of Monash) who contributed to the statistical analysis. Medical writing assistance was provided by Evelina Matekonyte, inScience Communications, Springer Healthcare Ltd., London, UK, and funded by Merck KGaA, Darmstadt, Germany. Funding This study was funded by Merck KGaA, Darmstadt, Germany. Merck KGaA (Darmstadt, Germany) designed and approved the study, took part in data collection and data analysis, and contributed to the data interpretation and final draft of the manuscript. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication.Peer reviewedPublisher PD

    Review of dohan eherenfest et al. (2009) on “classification of platelet concentrates: from pure platelet-rich plasma (p-prp) to leucocyte- and platelet-rich fibrin (l-prf)”

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    This classic discusses the original publication of Dohan Eherenfest et al. on "Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)", in which the authors propose four categories of platelet concentrates depending on their leukocyte and fibrin content (P-PRP, leucocyte- and platelet-rich plasma (L-PRP), pure platelet-rich fibrin (P-PRF), and L-PRF) to group a "jungle" of products in which the term platelet-rich plasma (PRP) was used indistinctly. They were able to identify common factors such as: (1) the use of anticoagulant and immediate centrifugation of the blood after its collection, (2) most preparation techniques allowed platelet concentrate preparation within an hour, (3) the centrifugation aimed to separate the blood in layers that would allow the extraction of specific fractions, and (4) the product was activated with thrombin or calcium chloride. The reviewed manuscript has been listed among the most cited PRP articles in regenerative medicine, with more than 800 citations, driving the current scientific research and clinical practice by categorizing L-PRP and P-PRP (now, leukocyte-poor PRP). The classification has also opened the door to understanding intrinsic biological mechanisms between the platelets, leukocytes, fibrin, and growth factors, later considered for studying the proliferation and differentiation of cells in different tissues affected by PRP. Since the initial classification of platelet concentrates, several other classification systems have been proposed and published in the current literature, such as the PAW, Mishra, PLRA, DEPA, MARSPILL, etc. These classifications have identified important aspects of PRP that affect the biological composition and, ultimately, the indications and outcomes. To date, there is still a lack of standardization in sample preparation, cohort heterogeneity, and incomplete reporting of sample preparation utilized, leading to a lack of clarity and challenging researchers and clinicians
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