7 research outputs found
La educaciĂłn en valores como estrategia de desarrollo y consolidaciĂłn de la persona moral
Se plantea la centralidad de los valores a través de una serie de
reflexiones sociales y pedagĂłgicas que pretenden conformar las
lĂneas de actuaciĂłn asociadas al afianzamiento y mejora de la
personalidad moral.
Resulta urgente procurar un desarrollo moral de la persona que
se oriente en dos direcciones complementarias: una, hacia el
logro de una felicidad interior no egoĂsta y otra, hacia la
consecuciĂłn de una felicidad fraternal y hospitalaria
Application of zeolites for the production of biofuels and furans from hexose sugars in ethanol.
The use of zeolites as catalysts in the transformation of glucose and 5-hydroxymethylfurfural (HMF) into 5-ethoxymethylfurfural (EMF) was evaluated. The behaviour of the catalysts could be explained by their morphology, composition, acid properties and chemical coordination of the active sites. The progress of the reaction was followed by High Performance Liquid Chromatography (HPLC) and 13C Nuclear Magnetic Resonance (NMR). Several intermediates were identified, and a reaction path is proposed. Different cosolvents were also employed in this study to enhance the selectivity towards different possible valuable compounds, and they were found to have a positive influence for the production of EMF and furfural.Funding for open access charge: Universidad de MĂĄlaga / CBU
SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer
Background: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of
tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular
Carcinoma (HCC).
Methods: Herein we have overexpressed LKB1 in human hepatoma cells and by using histidine pull-down assay
we have investigated the role of the hypoxia-related post-translational modification of Small Ubiquitin-related
Modifier (SUMO)ylation in the regulation of LKB1 oncogenic role. Molecular modelling between LKB1 and its
interactors, involved in regulation of LKB1 nucleocytoplasmic shuttling and LKB1 activity, was performed. Finally,
high affinity SUMO binding entities-based technology were used to validate our findings in a pre-clinical mouse
model and in clinical HCC.
Findings: We found that in human hepatoma cells under hypoxic stress, LKB1 overexpression increases cell viability and aggressiveness in association with changes in LKB1 cellular localization. Moreover, by using sitedirected mutagenesis, we have shown that LKB1 is SUMOylated by SUMO-2 at Lys178 hampering LKB1
nucleocytoplasmic shuttling and fueling hepatoma cell growth. Molecular modelling of SUMO modified LKB1 further confirmed steric impedance between SUMOylated LKB1 and the STe20-Related ADaptor cofactor (STRADα),
involved in LKB1 export from the nucleus. Finally, we provide evidence that endogenous LKB1 is modified by
SUMO in pre-clinical mouse models of HCC and clinical HCC, where LKB1 SUMOylation is higher in fast growing
tumors.
Interpretation: Overall, SUMO-2 modification of LKB1 at Lys178 mediates LKB1 cellular localization and its oncogenic role in liver cancer
Cell wall polysaccharides isolated from the fungus Neotestudina rosatii, one of the etiologic agents of mycetoma in man
Global urban environmental change drives adaptation in white clover
Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale
Search for intermediate-mass black hole binaries in the third observing run of Advanced LIGO and Advanced Virgo
International audienceIntermediate-mass black holes (IMBHs) span the approximate mass range 100â105âMâ, between black holes (BHs) that formed by stellar collapse and the supermassive BHs at the centers of galaxies. Mergers of IMBH binaries are the most energetic gravitational-wave sources accessible by the terrestrial detector network. Searches of the first two observing runs of Advanced LIGO and Advanced Virgo did not yield any significant IMBH binary signals. In the third observing run (O3), the increased network sensitivity enabled the detection of GW190521, a signal consistent with a binary merger of mass âŒ150âMâ providing direct evidence of IMBH formation. Here, we report on a dedicated search of O3 data for further IMBH binary mergers, combining both modeled (matched filter) and model-independent search methods. We find some marginal candidates, but none are sufficiently significant to indicate detection of further IMBH mergers. We quantify the sensitivity of the individual search methods and of the combined search using a suite of IMBH binary signals obtained via numerical relativity, including the effects of spins misaligned with the binary orbital axis, and present the resulting upper limits on astrophysical merger rates. Our most stringent limit is for equal mass and aligned spin BH binary of total mass 200âMâ and effective aligned spin 0.8 at 0.056 Gpcâ3 yrâ1 (90% confidence), a factor of 3.5 more constraining than previous LIGO-Virgo limits. We also update the estimated rate of mergers similar to GW190521 to 0.08 Gpcâ3 yrâ1.Key words: gravitational waves / stars: black holes / black hole physicsCorresponding author: W. Del Pozzo, e-mail: [email protected]â Deceased, August 2020