23 research outputs found

    Die Entwicklung des menschlichen Auges

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    Adaptive sequential design for regression on multi-resolution bases

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    International audienceThis work investigates the problem of construction of designs for estimation and discrimination between competing linear models. In our framework, the unknown signal is observed with the addition of a noise and only a few evaluations of the noisy signal are available. The model selection is performed in a multi-resolution setting. In this setting, the locations of discrete sequential D and A designs are precisely constraint in a small number of explicit points. Hence, an efficient stochastic algorithm can be constructed that alternately improves the design and the model. Several numerical experiments illustrate the efficiency of our method for regression. One can also use this algorithm as a preliminary step to build response surfaces for sensitivity analysis

    Polysaccharide degradation by the Bacteroidetes: mechanisms and nomenclature

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    The Bacteroidetes phylum is renowned for its ability to degrade a wide range of complex carbohydrates, a trait that has enabled its dominance in many diverse environments. The best studied species inhabit the human gut microbiome and use polysaccharide utilization loci (PULs), discrete genetic structures that encode proteins involved in the sensing, binding, deconstruction, and import of target glycans. In many environmental species, polysaccharide degradation is tightly coupled to the phylum-exclusive type IX secretion system (T9SS), which is used for the secretion of certain enzymes and is linked to gliding motility. In addition, within specific species these two adaptive systems (PULs and T9SS) are intertwined, with PUL-encoded enzymes being secreted by the T9SS. Here, we discuss the most noteworthy PUL and non-PUL mechanisms that confer specific and rapid polysaccharide degradation capabilities to the Bacteroidetes in a range of environments. We also acknowledge that the literature showcasing examples of PULs is rapidly expanding and developing a set of assumptions that can be hard to track back to original findings. Therefore, we present a simple universal description of conserved PUL functions and how they are determined, while proposing a common nomenclature describing PULs and their components, to simplify discussion and understanding of PUL systems
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