Digital inclusion and functional capacity of older adults living in Florianópolis, Santa Catarina, Brazil (EpiFloripa 2009-2010)

OBJETIVO: Estudar a relação entre inclusão digital, na forma de troca de mensagens pela Internet, e capacidade funcional de idosos residentes em Florianópolis, Santa Catarina, Brasil. MÉTODOS: Utilizaram-se dados do EpiFloripa Idoso, um estudo transversal de base populacional com idosos (60+ anos) realizado entre 2009 e 2010. A capacidade funcional foi representada pela dificuldade ou incapacidade na realização de atividades básicas ou instrumentais da vida diária, e constituiu a variável dependente denominada dependência funcional. A variável independente principal foi a capacidade autorreferida de enviar e receber mensagens pela Internet usando um computador. Razões de prevalência (PR) e intervalos de confiança de 95% (IC95%) foram estimados em modelo multivariável por regressão de Poisson. RESULTADOS: A amostra compreendeu 1.656 idosos entre 60 e 102 anos com idade média de 70,39 anos (DP = 7,79). Os idosos que conseguiam enviar e receber mensagens pela Internet sem dificuldade apresentaram prevalência significativamente menor de dependência funcional moderada/grave (RP = 0,61; IC95%: 0,40 - 0,94) após ajuste para fatores demográficos, socioeconômicos, de saúde e comportamentais. CONCLUSÕES: A troca de mensagens pela Internet possui forte associação com independência funcional. Não é possível inferir a relação de causalidade dessa associação. Estudos alicerçam a hipótese de que a troca de mensagens pela Internet e a independência funcional tenham uma associação bidirecional, aditiva e sinérgica. Estudos longitudinais poderiam investigar os mecanismos envolvidos nessa associação, para fundamentar políticas de inclusão digital de idosos e para identificar qual o perfil de idosos que mais se beneficiaria com essa inclusão

MITS: the Multi-Imaging Transient Spectrograph for SOXS

The Son Of X-Shooter (SOXS) is a medium resolution spectrograph R~4500 proposed for the ESO 3.6 m NTT. We present the optical design of the UV-VIS arm of SOXS which employs high efficiency ion-etched gratings used in first order (m=1) as the main dispersers. The spectral band is split into four channels which are directed to individual gratings, and imaged simultaneously by a single three-element catadioptric camera. The expected throughput of our design is >60% including contingency. The SOXS collaboration expects first light in early 2021. This paper is one of several papers presented in these proceedings describing the full SOXS instrument

Optical design of the SOXS spectrograph for ESO NTT

An overview of the optical design for the SOXS spectrograph is presented. SOXS (Son Of X-Shooter) is the new wideband, medium resolution (R>4500) spectrograph for the ESO 3.58m NTT telescope expected to start observations in 2021 at La Silla. The spectroscopic capabilities of SOXS are assured by two different arms. The UV-VIS (350-850 nm) arm is based on a novel concept that adopts the use of 4 ion-etched high efficiency transmission gratings. The NIR (800- 2000 nm) arm adopts the '4C' design (Collimator Correction of Camera Chromatism) successfully applied in X-Shooter. Other optical sub-systems are the imaging Acquisition Camera, the Calibration Unit and a pre-slit Common Path. We describe the optical design of the five sub-systems and report their performance in terms of spectral format, throughput and optical quality. This work is part of a series of contributions describing the SOXS design and properties as it is about to face the Final Design Review.Comment: 9 pages, 9 figures, published in SPIE Proceedings 1070

The VIS detector system of SOXS

SOXS will be a unique spectroscopic facility for the ESO NTT telescope able to cover the optical and NIR bands thanks to two different arms: the UV-VIS (350-850 nm), and the NIR (800-1800 nm). In this article, we describe the design of the visible camera cryostat and the architecture of the acquisition system. The UV-VIS detector system is based on a e2v CCD 44-82, a custom detector head coupled with the ESO continuous ow cryostats (CFC) cooling system and the NGC CCD controller developed by ESO. This paper outlines the status of the system and describes the design of the different parts that made up the UV-VIS arm and is accompanied by a series of contributions describing the SOXS design solutions.Comment: 9 pages, 13 figures, to be published in SPIE Proceedings 1070

The Acquisition Camera System for SOXS at NTT

SOXS (Son of X-Shooter) will be the new medium resolution (R$\sim$4500 for a 1 arcsec slit), high-efficiency, wide band spectrograph for the ESO-NTT telescope on La Silla. It will be able to cover simultaneously optical and NIR bands (350-2000nm) using two different arms and a pre-slit Common Path feeding system. SOXS will provide an unique facility to follow up any kind of transient event with the best possible response time in addition to high efficiency and availability. Furthermore, a Calibration Unit and an Acquisition Camera System with all the necessary relay optics will be connected to the Common Path sub-system. The Acquisition Camera, working in optical regime, will be primarily focused on target acquisition and secondary guiding, but will also provide an imaging mode for scientific photometry. In this work we give an overview of the Acquisition Camera System for SOXS with all the different functionalities. The optical and mechanical design of the system are also presented together with the preliminary performances in terms of optical quality, throughput, magnitude limits and photometric properties.Comment: 9 pages, 7 figures, SPIE conferenc

Transcription Factor EB Controls Metabolic Flexibility during Exercise

The transcription factor EB (TFEB) is an essential component of lysosomal biogenesis and autophagy for the adaptive response to food deprivation. To address the physiological function of TFEB in skeletal muscle, we have used muscle-specific gain- and loss-of-function approaches. Here, we show that TFEB controls metabolic flexibility in muscle during exercise and that this action is independent of peroxisome proliferator-activated receptor-γ coactivator1α (PGC1α). Indeed, TFEB translocates into the myonuclei during physical activity and regulates glucose uptake and glycogen content by controlling expression of glucose transporters, glycolytic enzymes, and pathways related to glucose homeostasis. In addition, TFEB induces the expression of genes involved in mitochondrial biogenesis, fatty acid oxidation, and oxidative phosphorylation. This coordinated action optimizes mitochondrial substrate utilization, thus enhancing ATP production and exercise capacity. These findings identify TFEB as a critical mediator of the beneficial effects of exercise on metabolism

Architecture of the SOXS instrument control software

SOXS (Son Of X-Shooter) is a new spectrograph for the ESO NTT telescope, currently in the final design phase. The main instrument goal is to allow the characterization of transient sources based on alerts. It will cover from near-infrared to visible bands with a spectral resolution of $R \sim 4500$ using two separate, wavelength-optimized spectrographs. A visible camera, primarily intended for target acquisition and secondary guiding, will also provide a scientific "light" imaging mode. In this paper we present the current status of the design of the SOXS instrument control software, which is in charge of controlling all instrument functions and detectors, coordinating the execution of exposures, and implementing all observation, calibration and maintenance procedures. Given the extensive experience of the SOXS consortium in the development of instruments for the VLT, we decided to base the design of the Control System on the same standards, both for hardware and software control. We illustrate the control network, the instrument functions and detectors to be controlled, the overall design of SOXS Instrument Software (INS) and its main components. Then, we provide details about the control software for the most SOXS-specific features: control of the COTS-based imaging camera, the flexures compensation system and secondary guiding.Comment: 8 pages, 5 figure

SOXS Control Electronics Design

SOXS (Son Of X-Shooter) is a unique spectroscopic facility that will operate at the ESO New Technology Telescope (NTT) in La Silla from 2020 onward. The spectrograph will be able to cover simultaneously the UV-VIS and NIR bands exploiting two different arms and a Common Path feeding system. We present the design of the SOXS instrument control electronics. The electronics controls all the movements, alarms, cabinet temperatures, and electric interlocks of the instrument. We describe the main design concept. We decided to follow the ESO electronic design guidelines to minimize project time and risks and to simplify system maintenance. The design envisages Commercial Off-The-Shelf (COTS) industrial components (e.g. Beckhoff PLC and EtherCAT fieldbus modules) to obtain a modular design and to increase the overall reliability and maintainability. Preassembled industrial motorized stages are adopted allowing for high precision assembly standards and a high reliability. The electronics is kept off-board whenever possible to reduce thermal issues and instrument weight and to increase the accessibility for maintenance purpose. The instrument project went through the Preliminary Design Review in 2017 and is currently in Final Design Phase (with FDR in July 2018). This paper outlines the status of the work and is part of a series of contributions describing the SOXS design and properties after the instrument Preliminary Design Review.Comment: 10 pages, 7 figures, to be publised in SPIE Proceedings 10707-9

A Ihara-Bass Formula for Non-Boolean Matrices and Strong Refutations of Random CSPs

We define a notion of "non-backtracking" matrix associated to any symmetric matrix, and we prove a "Ihara-Bass" type formula for it. Previously, these notions were known only for symmetric 0/1 matrices. We use this theory to prove new results on polynomial-time strong refutations of random constraint satisfaction problems with $k$ variables per constraints (k-CSPs). For a random k-CSP instance constructed out of a constraint that is satisfied by a $p$ fraction of assignments, if the instance contains $n$ variables and $n^{k/2} / \epsilon^2$ constraints, we can efficiently compute a certificate that the optimum satisfies at most a $p+O_k(\epsilon)$ fraction of constraints. Previously, this was known for even $k$, but for odd $k$ one needed $n^{k/2} (\log n)^{O(1)} / \epsilon^2$ random constraints to achieve the same conclusion. Although the improvement is only polylogarithmic, it overcomes a significant barrier to these types of results. Strong refutation results based on current approaches construct a certificate that a certain matrix associated to the k-CSP instance is quasirandom. Such certificate can come from a Feige-Ofek type argument, from an application of Grothendieck's inequality, or from a spectral bound obtained with a trace argument. The first two approaches require a union bound that cannot work when the number of constraints is $o(n^{\lceil k/2 \rceil})$ and the third one cannot work when the number of constraints is $o(n^{k/2} \sqrt{\log n})$.Comment: 46 page