Can cigarette smoking make a man appear sexier and stronger to women?

This paper focuses on naďve theories, illusions, and misconceptions regarding the outcome of men’s cigarette smoking on female impressions. Beliefs about those outcomes were examined in a correlational study and their content was compared with the results of previous experimental verifi cation. Male and female participants (N = 396) responded to an advertisement placed on an online general-interest forum and completed a questionnaire concerning their beliefs about the impact of cigarette smoking in men on their self-presentation to women. This included impressions of attractiveness, intelligence, strength, sexiness, and other male qualities. Results show that people believe that smoking decreases a man’s perceived aptitude for being a woman’s long-term partner. The belief that smoking enhances a man’s attractiveness to a woman as a short-term partner was limited to female smokers. Non-smokers believed that smoking in men signals poor impulse-control. Gender, age, smoking status (smoker vs non-smoker), and number of cigarettes smoked daily appeared to play an important role in predicting expressed beliefs. Young female smokers were indicated as the subgroup bearing the most optimistic illusions

Does communal context bring the worst in narcissists?

The present experiment (N = 95) investigated the relations of narcissism with social value orientation under façade conditions of testing communal or agentic traits (or none - in a control condition). The results indicated that narcissism predicted less willingness to share resources with others and more competitive orientation in a façade communal condition compared to the remaining two conditions: control and agentic. The results confirm narcissistic disregard for communal domain and are consistent with the extended agency model of narcissism and the “success as a drawback” effect

Do narcissism and emotional intelligence win us friends? Modeling dynamics of peer popularity using inferential network analysis

This research investigated effects of narcissism and emotional intelligence (EI) on popularity in social networks. In a longitudinal field study we examined the dynamics of popularity in 15 peer groups in two waves (N=273).We measured narcissism, ability EI, explicit and implicit self-esteem. In addition, we measured popularity at zero acquaintance and three months later. We analyzed the data using inferential network analysis (temporal exponential random graph modeling, TERGM) accounting for self-organizing network forces. People high in narcissism were popular, but increased less in popularity over time than people lower in narcissism. In contrast, emotionally intelligent people increased more in popularity over time than less emotionally intelligent people. The effects held when we controlled for explicit and implicit self-esteem. These results suggest that narcissism is rather disadvantageous and that EI is rather advantageous for long-term popularity

The relationship of narcissism with tendency to react with anger and hostility : the role of neuroticism and emotion regulation ability

The present study examined the relationship of grandiose and vulnerable narcissism with dispositional anger and hostility. We investigated the roles of neuroticism, emotional intelligence, and gender in this relationship, using a sample of 405 participants. The results indicated that vulnerable narcissism was associated with a higher tendency toward anger and hostility, and that neuroticism accounted for a large part of this association. Poor emotion managing, known as strategic emotion regulation ability, also played a role in hostility related to vulnerable narcissism, especially among men. When emotional stability was controlled for, grandiose narcissism showed links to anger and hostility. We concluded that high neuroticism and poor emotion regulation abilities among vulnerable narcissists contribute to increased anger/hostility, whereas emotional stability likely protects grandiose narcissists against these internal aspects of aggression. The significant relationships between both forms of narcissism with aggression, remaining after neuroticism and emotion regulation were accounted for, suggest that there is another underlying source of this link. Finally, we found that controlling for interindividual differences in neuroticism significantly increased the relationship between vulnerable and grandiose narcissism, suggesting the existence of the common core of narcissism

Individual differences in response to uncertainty and decision making : the role of behavioral inhibition system and need for closure

In two studies, we examined the influence of behavioral inhibition system (BIS) and need for closure (NFC) on information processing in decision making. We expected that BIS would regulate behavior in a decisional context and that this relationship would be mediated by epistemic motivation expressed by NFC. In addition, drawing on contradictory findings in the literature on anxiety, NFC, and information processing, we investigated the moderating role of decision rules. The results supported our predictions. BIS was strongly and positively related to NFC, and through NFC it was related to decision-making style. Moreover, decision task characteristics moderated the relationship between NFC and decision making. When a task did not offer a confident decision rule, high NFC participants prolonged the information search more than low NFC individuals. However, when a reliable strategy was suggested, high NFC participants behaved in line with it. These results are discussed within an uncertainty management framework

The Dirty Dozen Scale: Validation of a Polish Version and Extension of the Nomological Net

In five studies (total N = 1300) we developed and validated a Polish version of the Dirty Dozen measure (DTDD-P) that measures the three traits of the Dark Triad, Machiavellianism, psychopathy, and narcissism. We detail the presence and stability of a bifactor structure of the 12 items and present evidence for good internal consistency and test–retest reliability. We examine the nomological network surrounding the Dark Triad and show that both the Dark Triad total score and the subscales have acceptable validity. We also present evidence on the Dark Triad and moral behavior. Dark Triad predicts utilitarian moral choice (e.g., approval for sacrificing somebody's life for the sake of saving others) and this link is mediated by low empathic concern. In total, our results suggest that the Polish Dirty Dozen—Parszywa Dwunastka—is valid, stable, and useful for the study of lingering puzzles in the literature

Higher heart rate variability predicts better affective interaction quality in non-intimate social interactions

Adaptive emotional responding is crucial for psychological well-being and the quality of social interactions. Resting heart rate variability (HRV), a measure of autonomic nervous system activity, has been suggested to index individual differences in emotion regulation (ER). As non-intimate social interactions require more regulatory efforts than intimate social interactions, we predicted that the association between HRV and affective interaction quality is moderated by the perceived intimacy of the exchange. Thus, we expected higher HRV to be particularly beneficial for affective interaction quality in non-intimate social interactions. Resting HRV was measured in the laboratory (N = 144). Subsequently, participants reported their affective interaction quality—as indicated by more positive and fewer negative emotions perceived in the self and the other—during an experience-sampling social interaction diary task. As predicted, in non-intimate interactions, individuals with higher HRV reported more positive and fewer negative emotions and perceived fewer negative emotions in their interaction partners. The results provide further insights into the relationship between HRV and emotional experiences during social interactions

Structures of Drosophila Cryptochrome and Mouse Cryptochrome1 Provide Insight into Circadian Function

SummaryDrosophila cryptochrome (dCRY) is a FAD-dependent circadian photoreceptor, whereas mammalian cryptochromes (CRY1/2) are integral clock components that repress mCLOCK/mBMAL1-dependent transcription. We report crystal structures of full-length dCRY, a dCRY loop deletion construct, and the photolyase homology region of mouse CRY1 (mCRY1). Our dCRY structures depict Phe534 of the regulatory tail in the same location as the photolesion in DNA-repairing photolyases and reveal that the sulfur loop and tail residue Cys523 plays key roles in the dCRY photoreaction. Our mCRY1 structure visualizes previously characterized mutations, an NLS, and MAPK and AMPK phosphorylation sites. We show that the FAD and antenna chromophore-binding regions, a predicted coiled-coil helix, the C-terminal lid, and charged surfaces are involved in FAD-independent mPER2 and FBXL3 binding and mCLOCK/mBMAL1 transcriptional repression. The structure of a mammalian cryptochrome1 protein may catalyze the development of CRY chemical probes and the design of therapeutic metabolic modulators

Characterization of SARS-CoV-2 replication complex elongation and proofreading activity

The replication complex (RC) of SARS-CoV-2 was recently shown to be one of the fastest RNA-dependent RNA polymerases of any known coronavirus. With this rapid elongation, the RC is more prone to incorporate mismatches during elongation, resulting in a highly variable genomic sequence. Such mutations render the design of viral protein targets difficult, as drugs optimized for a given viral protein sequence can quickly become inefficient as the genomic sequence evolves. Here, we use biochemical experiments to characterize features of RNA template recognition and elongation fidelity of the SARS-CoV-2 RdRp, and the role of the exonuclease, nsp14. Our study highlights the 2′OH group of the RNA ribose as a critical component for RdRp template recognition and elongation. We show that RdRp fidelity is reduced in the presence of the 3′ deoxy-terminator nucleotide 3′dATP, which promotes the incorporation of mismatched nucleotides (leading to U:C, U:G, U:U, C:U, and A:C base pairs). We find that the nsp10–nsp14 heterodimer is unable to degrade RNA products lacking free 2′OH or 3′OH ribose groups. Our results suggest the potential use of 3′ deoxy-terminator nucleotides in RNA-derived oligonucleotide inhibitors as antivirals against SARS-CoV-2

Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective

A clinical casein kinase 2 inhibitor, CX-4945 (silmitasertib), shows significant affinity toward the DYRK1A and GSK3β kinases, involved in down syndrome phenotypes, Alzheimer’s disease, circadian clock regulation, and diabetes. This off-target activity offers an opportunity for studying the effect of the DYRK1A/GSK3β kinase system in disease biology and possible line extension. Motivated by the dual inhibition of these kinases, we solved and analyzed the crystal structures of DYRK1A and GSK3β with CX-4945. We built a quantum-chemistry-based model to rationalize the compound affinity for CK2α, DYRK1A, and GSK3β kinases. Our calculations identified a key element for CK2α’s subnanomolar affinity to CX-4945. The methodology is expandable to other kinase selectivity modeling. We show that the inhibitor limits DYRK1A- and GSK3β-mediated cyclin D1 phosphorylation and reduces kinase-mediated NFAT signaling in the cell. Given the CX-4945’s clinical and pharmacological profile, this inhibitory activity makes it an interesting candidate with potential for application in additional disease areas