WEB-BASED LABORATORY MODULES FOR LINEAR AND ANGULAR KINEMATICS

Two Web-based laboratory modules have been developed and implemented for reinforcing basic concepts in kinematics in the learning of biomechanics. In the linear kinematics module, students digitize the mid-hip, heel and toe on images showing the side views of sprinting, running and jogging and analyze the stride length and time and velocity alTlong these actions. For the angular kinematics module, students digitize the near shoulder, hip, and knee on images of one complete revolution of a forward giant swing of a gymnast and determine the hip angle, the angular velocity and acceleration of the trunk. Evaluations and feedback from biomechanics instructors and students in biomechanics courses have suggested that these modules have the potential to be effective educational tools

Longitudinal and transverse fermion-boson vertex in QED at finite temperature in the HTL approximation

We evaluate the fermion-photon vertex in QED at the one loop level in Hard Thermal Loop approximation and write it in covariant form. The complete vertex can be expanded in terms of 32 basis vectors. As is well known, the fermion-photon vertex and the fermion propagator are related through a Ward-Takahashi Identity (WTI). This relation splits the vertex into two parts: longitudinal (Gamma_L) and transverse (Gamma_T). Gamma_L is fixed by the WTI. The description of the longitudinal part consumes 8 of the basis vectors. The remaining piece Gamma_T is then written in terms of 24 spin amplitudes. Extending the work of Ball and Chiu and Kizilersu et. al., we propose a set of basis vectors T^mu_i(P_1,P_2) at finite temperature such that each of these is transverse to the photon four-momentum and also satisfies T^mu_i(P,P)=0, in accordance with the Ward Identity, with their corresponding coefficients being free of kinematic singularities. This basis reduces to the form proposed by Kizilersu et. al. at zero temperature. We also evaluate explicitly the coefficient of each of these vectors at the above-mentioned level of approximation.Comment: 13 pages, uses RevTe

Shape-Based Separation of Micro-/Nanoparticles in Liquid Phases

The production of particles with shape-specific properties is reliant upon the separation of micro-/nanoparticles of particular shapes from particle mixtures of similar volumes. However, compared to a large number of size-based particle separation methods, shape-based separation methods have not been adequately explored. We review various up-to-date approaches to shape-based separation of rigid micro-/nanoparticles in liquid phases including size exclusion chromatography, field flow fractionation, deterministic lateral displacement, inertial focusing, electrophoresis, magnetophoresis, self-assembly precipitation, and centrifugation. We discuss separation mechanisms by classifying them as either changes in surface interactions or extensions of size-based separation. The latter includes geometric restrictions and shape-dependent transport properties

Deviations from Fermi-Liquid behaviour in (2+1)-dimensional Quantum Electrodynamics and the normal phase of high-TcT_c Superconductors

We argue that the gauge-fermion interaction in multiflavour quantum electrodynamics in $(2 + 1)$-dimensions is responsible for non-fermi liquid behaviour in the infrared, in the sense of leading to the existence of a non-trivial (quasi) fixed point that lies between the trivial fixed point (at infinite momenta) and the region where dynamical symmetry breaking and mass generation occurs. This quasi-fixed point structure implies slowly varying, rather than fixed, couplings in the intermediate regime of momenta, a situation which resembles that of (four-dimensional) `walking technicolour' models of particle physics. The inclusion of wave-function renormalization yields marginal $O(1/N)$-corrections to the `bulk' non-fermi liquid behaviour caused by the gauge interaction in the limit of infinite flavour number. Such corrections lead to the appearance of modified critical exponents. In particular, at low temperatures there appear to be logarithmic scaling violations of the linear resistivity of the system of order $O(1/N)$. Connection with the anomalous normal-state properties of certain condensed matter systems relevant for high-temperature superconductivity is briefly discussed. The relevance of the large (flavour) $N$ expansion to the fermi-liquid problem is emphasized. As a partial result of our analysis, we point out the absence of Charge-Density-Wave Instabilities from the effective low-energy theory, as a consequence of gauge invariance.Comment: Latex file, 35 pages, Two figures not included, available upon reques

A Case of Recurrent Multifocal Central Giant Cell Granulomas

One case of recurrent multifocal central giant cell granulomas (CGCG) is presented. Initially, the lesions presented concurrently in the maxilla and mandible with subsequent recurrence in the mandible. Now, two recurrences are seen in the maxillary sinus and ethmoid region. The literature regarding multifocal CGCG is reviewed

Global chemical effects of the microbiome include new bile-acid conjugations

A mosaic of cross-phylum chemical interactions occurs between all metazoans and their microbiomes. A number of molecular families that are known to be produced by the microbiome have a marked effect on the balance between health and disease. Considering the diversity of the human microbiome (which numbers over 40,000 operational taxonomic units), the effect of the microbiome on the chemistry of an entire animal remains underexplored. Here we use mass spectrometry informatics and data visualization approaches to provide an assessment of the effects of the microbiome on the chemistry of an entire mammal by comparing metabolomics data from germ-free and specific-pathogen-free mice. We found that the microbiota affects the chemistry of all organs. This included the amino acid conjugations of host bile acids that were used to produce phenylalanocholic acid, tyrosocholic acid and leucocholic acid, which have not previously been characterized despite extensive research on bile-acid chemistry. These bile-acid conjugates were also found in humans, and were enriched in patients with inflammatory bowel disease or cystic fibrosis. These compounds agonized the farnesoid X receptor in vitro, and mice gavaged with the compounds showed reduced expression of bile-acid synthesis genes in vivo. Further studies are required to confirm whether these compounds have a physiological role in the host, and whether they contribute to gut diseases that are associated with microbiome dysbiosis

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

Designing Play for Dark Times

This article reports on a knowledge-exchange network project that had the core aim of informing the development of a video game for hospitalized children. In order to do this, it brought together hospital play specialists, academics and representatives from the digital games industry to co-produce knowledge that could be used in the future production of such a product. The project came about in relation to having identified a lack of research about and actual physical-digital games designed specifically for children living in adverse (‘dark’) times. This is despite the fact that there is a substantial body of research that has shown how play is beneficial for helping children make sense of what is happening to them, and thus results in better mental, emotional and physical well-being. The article describes a selection of the knowledge-exchange presentations and activities that were used throughout the project. Specifically, these activities used art-and-design-based methods as a means of knowing through making. The methods are discussed in relation to how they generated knowledge that responded to the objectives of the project. These were, firstly, to allow children to express emotions about their illness and/or being in hospital; secondly, to offer information on the hospital experience; and, finally, to develop a design that could cross physical and digital platforms with a space for open-ended child-directed play. As the overarching intention of the project was to generate knowledge across the stakeholders, the project ended by materializing the core findings from the project into a paper prototype of a game on which a hypothetical digital-physical version could be based

Mapping the human genetic architecture of COVID-19

The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-191,2, host genetics may also be important. Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes. We formed a global network of researchers to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity. Here we describe the results of three genome-wide association meta-analyses that consist of up to 49,562 patients with COVID-19 from 46 studies across 19 countries. We report 13 genome-wide significant loci that are associated with SARS-CoV-2 infection or severe manifestations of COVID-19. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases3–7. They also represent potentially actionable mechanisms in response to infection. Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID-19 although not for type II diabetes. The identification of novel host genetic factors associated with COVID-19 was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks. This working model of international collaboration underscores what is possible for future genetic discoveries in emerging pandemics, or indeed for any complex human disease