A Trip Through the Divine Comedy: An Allegory for Depression and its Role in Bibliotherapy

Dante the Pilgrim, the main character of Dante Alighieri’s La Divina Commedia, has his journey through Hell, Purgatory, and Heaven recorded by Dante the Poet in poetic form. In the literal sense of things, readers follow Dante the Pilgrim’s journey downward into the infernal hellscape, upward onto a mountain of purgation and atonement, and into the metaphysical world of the divine. Allegorically, however, readers can also choose to view Dante the Pilgrim’s journey through The Divine Comedy as that of a person experiencing the hopelessness of depression, the challenging climb upward and outward of healing after spiraling deeply inward and, then, upon the journey’s conclusion, rejoicing in streams of light as the heavy weight of the darkness—of depression—is lifted. Throughout this thesis, I isolate instances scattered throughout Dante’s poetry that can allegorically represent the journey one undertakes as the fog of depression settles in and the valid possibility of including the medieval work into the practice of bibliotherapy

Plaintiff\u27s Motion to Remand Denied: Arguing for Pre-Service Removal under the Plain Language of the Forum-Defendant Rule

This Note will examine all sides of the district court split and ultimately argue in favor of the plain language of the forum-defendant rule to permit pre-service removal

Plaintiff\u27s Motion to Remand Denied: Arguing for Pre-Service Removal under the Plain Language of the Forum-Defendant Rule

This Note will examine all sides of the district court split and ultimately argue in favor of the plain language of the forum-defendant rule to permit pre-service removal

Symbolic Quantum Circuit Simplification in SymPy

In the field of quantum information science, one can design a series of quantum logic operations known as a circuit. Circuits are the basis for quantum computations in quantum computing. As circuits will most likely be designed from a logical standpoint, there could exist mathematical redundancies which will lead to a larger circuit than necessary. These redundancies are computationally expensive, and there is a need for them to be found and eliminated to simplify the circuit. We present our research on finding the rules for simplifying circuits and its implementation in SymPy

Improving the Readout of Semiconducting Qubits

Semiconducting qubits are a promising platform for quantum computers. In particular, silicon spin qubits have made a number of advancements recently including long coherence times, high-fidelity single-qubit gates, two-qubit gates, and high-fidelity readout. However, all operations likely require improvement in fidelity and speed, if possible, to realize a quantum computer. Readout fidelity and speed, in general, are limited by circuit challenges centered on extracting low signal from a device in a dilution refrigerator connected to room temperature amplifiers by long coaxial cables with relatively high capacitance. Readout fidelity specifically is limited by the time it takes to reliably distinguish qubit states relative to the characteristic decay time of the excited state, T1. This dissertation explores the use of heterojunction bipolar transistor (HBT) circuits to amplify the readout signal of silicon spin qubits at cryogenic temperatures. The cryogenic amplification approach has numerous advantages including low implementation overhead, low power relative to the available cooling power, and high signal gain at the mixing chamber stage leading to around a factor of ten speedup in readout time for a similar signal-to-noise ratio. The faster readout time generally increases fidelity, since it is much faster than the T1 time. Two HBT amplification circuits have been designed and characterized. One design is a low-power, base-current biased configuration with non-linear gain (CB-HBT), and the second is a linear-gain, AC-coupled configuration (AC-HBT). They can operate at powers of 1 and 10 μW, respectfully, and not significantly heat electrons. The noise spectral density referred to the input for both circuits is around 15 to 30 fA/√Hz, which is low compared to previous cases such as the dual-stage, AC-coupled HEMT circuit at ~ 70 fA/√Hz. Both circuits achieve charge sensitivity between 300 and 400 μe/√Hz, which approaches the best alternatives (e.g., RF-SET at ~ 140 μe/√Hz) but with much less implementation overhead. For the single-shot latched charge readout performed, both circuits achieve high-fidelity readout in times \u3c 10 μs with bit error rates \u3c 10-3, which is a great improvement over previous work at \u3e 70 μs. The readout speed-up in principle also reduces the production of errors due to excited state relaxation by a factor of ~ 10. All of these results are possible with relatively simple, low-power transistor circuits which can be mounted close to the qubit device at the mixing chamber stage of the dilution refrigerator

Sustained Veggie: Considerations for Consistent On-Orbit Leafy Green Production

No abstract availabl

Using the Sirocco File System for high-bandwidth checkpoints.

The Sirocco File System, a file system for exascale under active development, is designed to allow the storage software to maximize quality of service through increased flexibility and local decision-making. By allowing the storage system to manage a range of storage targets that have varying speeds and capacities, the system can increase the speed and surety of storage to the application. We instrument CTH to use a group of RAM-based Sirocco storage servers allocated within the job as a high-performance storage tier to accept checkpoints, allowing computation to potentially continue asynchronously of checkpoint migration to slower, more permanent storage. The result is a 10-60x speedup in constructing and moving checkpoint data from the compute nodes. This demonstration of early Sirocco functionality shows a significant benefit for a real I/O workload, checkpointing, in a real application, CTH. By running Sirocco storage servers within a job as RAM-only stores, CTH was able to store checkpoints 10-60x faster than storing to PanFS, allowing the job to continue computing sooner. While this prototype did not include automatic data migration, the checkpoint was available to be pushed or pulled to disk-based storage as needed after the compute nodes continued computing. Future developments include the ability to dynamically spawn Sirocco nodes to absorb checkpoints, expanding this mechanism to other fast tiers of storage like flash memory, and sharing of dynamic Sirocco nodes between multiple jobs as needed

Effect of social status on behavioral and neural response to stress

Individuals respond differently to traumatic stress. Social status, which plays a key role in how animals experience and interact with their social environment, may influence how individuals respond to stressors. In this study, we used a conditioned defeat model to investigate whether social status alters susceptibility to the behavioral and neural consequences of traumatic stress. Conditioned defeat is a model in Syrian hamsters in which an acute social defeat encounter results in a long term increase in submissive behavior and a loss of normal territorial aggression. To establish social status, we weight matched and paired Syrian hamsters in daily aggressive encounters for two weeks to create dominant/subordinate relationships. We also included controls which were exposed daily to a clean empty cage for the same 14 day period. Twenty-four hours after the final pairing or empty cage exposure, subjects were divided into defeat and no defeat groups. Individuals in the defeat group received three 5 minute social defeats at 5 minute intervals in the cage of a larger aggressive hamster. Individuals in the no defeat group were exposed to the empty cage of a larger aggressive hamster at the same time intervals. In experiment 1, subjects of both groups were tested for conditioned defeat with a non-aggressive intruder 24 hours after social defeat training. In experiment 2, brains were collected 65 minutes following social defeat training and immunohistochemistry was performed for c-Fos protein, a marker of neural activation. We quantified the number of c-Fos immunopositive cells in brain regions known to be involved in stress and aggression, including the ventral medial prefrontal cortex, medial amygdala, and lateral and ventromedial hypothalamus. We found that subordinate animals showed significantly more conditioned defeat behavior than did dominants or controls, and subordinates showed significantly less c-Fos immunoreactivity than did dominants in all these brain regions. These results suggest that decreased neural activity in these brain regions corresponds to an increased susceptibility to conditioned defeat. In sum, social status plays an important role in how animals respond to social stressors and this corresponds to activity in specific brain areas

Evaluation of complex integrated care programmes: the approach in North West London

Background: Several local attempts to introduce integrated care in the English National Health Service have been tried, with limited success. The Northwest London Integrated Care Pilot attempts to improve the quality of care of the elderly and people with diabetes by providing a novel integration process across primary, secondary and social care organisations. It involves predictive risk modelling, care planning, multidisciplinary management of complex cases and an information technology tool to support information sharing. This paper sets out the evaluation approach adopted to measure its effect. Study design: We present a mixed methods evaluation methodology. It includes a quantitative approach measuring changes in service utilization, costs, clinical outcomes and quality of care using routine primary and secondary data sources. It also contains a qualitative component, involving observations, interviews and focus groups with patients and professionals, to understand participant experiences and to understand the pilot within the national policy context. Theory and discussion: This study considers the complexity of evaluating a large, multi-organisational intervention in a changing healthcare economy. We locate the evaluation within the theory of evaluation of complex interventions. We present the specific challenges faced by evaluating an intervention of this sort, and the responses made to mitigate against them. Conclusions: We hope this broad, dynamic and responsive evaluation will allow us to clarify the contribution of the pilot, and provide a potential model for evaluation of other similar interventions. Because of the priority given to the integrated agenda by governments internationally, the need to develop and improve strong evaluation methodologies remains strikingly important