The Grizzly, October 14, 2004

Walk for AIDS Awareness • Tenure: How to Make Your Vote Count • Powderpuff Football Raises Money for Cancer Research • Ex Voto Artist Speaks on Campus • Princeton Review Wants Your Opinion • Ursinus Faith • Learning Versus Earning in the College Years • From Humor to Horror: Poe on Poe Preview • Opinions: Who is to Blame for the Vioxx Withdrawal?; Segregation in Wismer; Phone Phollies; Blurring the Lines in American Media • Women\u27s Soccer Team Fools the Oddsmakers • Conduct in Pro Sports Becoming an Issuehttps://digitalcommons.ursinus.edu/grizzlynews/1568/thumbnail.jp

The Grizzly, September 16, 2004

Ursinus Goes Wireless • New Bookstore, New Look, Same Sentiments • Project Pericles Seeks to Remedy Political Apathy • Election 101: Who do you Side With? • Environmental Studies Professor gets with the Program • Ursinus Student Awarded $40,000 Grant • Are Ursinus Students Apathetic? • Ursinus Professors Dance the Night Away in Russia • Opinions: Should the Miss America Pageant Qualify as one of the Great American pastimes?; Why America Needs Four More Years of George W. Bush; Surviving \u27R-ships\u27 in College • Field Hockey Team Continues Where They Left Off • Men\u27s Soccer Shows Promisehttps://digitalcommons.ursinus.edu/grizzlynews/1564/thumbnail.jp

The Grizzly, October 26, 2006

Editorial: Putting the Pieces Back Together • Possible Scam Raises Concerns • Town Hall Meeting Brings Forth Campus Issues • Food Drive a Success • Fall is in the Air • Story Behind the Statue: Praha • Get to Know the Nominees • Opinions: Long Live Noise; Swept Under the Rug; Truth About Study Abroad • Women\u27s Volleyball Swept by Gettysburg • Bullets Offense Too Much for Bears • Bears Make Run for Playoffshttps://digitalcommons.ursinus.edu/grizzlynews/1722/thumbnail.jp

The Grizzly, September 28, 2006

Anti-Racist Writer and Educator Speaks to Ursinus Community • Spinach Recall and Dining at Ursinus • Smoking Ban Introduced • Images from Annual Fringe Festival • USGA Town Hall Meeting • Shades of Clay Closes • Beyond the Condom: Guide to Safe Sex • Constitution Day: A Review • An Afternoon with Johnny Knoxville and Bam Margera • Watson Fellowship • Opinions: The Core ; New Zack City • Soccer Struggles • Letter to the Editor • NCAA Drug Testinghttps://digitalcommons.ursinus.edu/grizzlynews/1719/thumbnail.jp

The Grizzly, September 9, 2004

Make a Difference: How to Register to Vote • Computer Thefts Under Investigation • Republicans say Yes to Four More Years with Bush • A Costly Look at Carelessness • STAR Sponsors One Night • Turnpike Tolls Increase for Commuters • Insider\u27s Tips to Undergraduate and Graduate Awards • Been to Synagogue Lately? • Safety First • Segregation by Letter? • The Pop-up Problem • UC Fringe Festival Opens Wednesday • Parking at Ursinus Robs Convenience • Opinions: Is Technology Making Life Easier or Lazier?; Life During Wartime; Lick it, Stamp it, Mail it and then Rock the Vote • 2004 Bears Football Outlook • UC Hires new Cross Country / Track & Field Coach • Now that Stanton is Gone: Men\u27s Basketball Preview • Bearcox Preview • Olympic Games: Competitive or Controversial?https://digitalcommons.ursinus.edu/grizzlynews/1563/thumbnail.jp

Development of autonomous magnetometer rotorcraft for wide area assessment

Large areas across the United States are potentially contaminated with UXO, with some ranges encompassing tens to hundreds of thousands of acres. Technologies are needed which will allow for cost effective wide area scanning with 1) near 100 % coverage and 2) near 100 % detection of subsurface ordnance or features indicative of subsurface ordnance. The current approach to wide area assessment is a multi-level one, in which medium - altitude fixed wing optical imaging is used for an initial site assessment. This assessment is followed with low altitude manned helicopter based magnetometry. Subsequent to this wide area assessment targeted surface investigations are performed using either towed geophysical sensor arrays or man portable sensors. In order to be an effective tool for small UXO detection, the sensing altitude for magnetic site investigations needs to be on the order of 1 – 3 meters. These altitude requirements mean that manned helicopter surveys will generally only be feasible in large, open and relatively flat terrains. While such surveys are effective in mapping large areas relatively fast there are substantial mobilization/demobilization, staffing and equipment costs associated with these surveys (resulting in costs of approximately $100-$150/acre). In addition, due to the low altitude there are substantial risks to pilots and equipment. Surface towed arrays provide high resolution maps but have other limitations, e.g. in their ability to navigate rough terrain effectively. There is thus a need for other systems which can be used for effective data collection. An UAV (Unmanned Aerial Vehicle) magnetometer platform is an obvious alternative. The motivation behind such a system is that it reduces risk to operators, is lower in initial and Operational and Maintenance (O&M) costs (and can thus potentially be applied to smaller sites) and has the potential of being more effective in terms of detection and possibly characterization (through the use of dynamic acquisition, i.e. survey mission inflight reprioritization). We describe and report on a one year effort with as primary goal to provide a recommendation to SERDP for a path forward in the implementation of one or more autonomous unmanned magnetometer rotorcraft platforms. This recommendation (which is provided in chapter 6) is based on the following three elements a) An assessment on the applicability of autonomous rotorcraft magnetometer systems to the current DoD site inventory, and an initial assessment of which type(s) of autonomous unmanned magnetometer rotorcraft platforms (in terms of performance characteristics such as payload, altitude, obstacle avoidance, production rate and flight time) would be most relevant to this inventory (chapter 3); b) An evaluation of the feasibility of assembling such platforms from commercial components (unmanned rotorcraft, control systems and sensors – both magnetometer sensors and supporting sensors). This evaluation included several highly successful field tests (chapter 4 and 5); c) A recommendation of the path forward, which includes a detailed outline of the efforts required in the design, assembly and testing of different modular platforms (chapter 6

Risk factors for COVID-19-related mortality in people with type 1 and type 2 diabetes in England: a population-based cohort study

Background: Diabetes has been associated with increased COVID-19-related mortality, but the association between modifiable risk factors, including hyperglycaemia and obesity, and COVID-19-related mortality among people with diabetes is unclear. We assessed associations between risk factors and COVID-19-related mortality in people with type 1 and type 2 diabetes. Methods: We did a population-based cohort study of people with diagnosed diabetes who were registered with a general practice in England. National population data on people with type 1 and type 2 diabetes collated by the National Diabetes Audit were linked to mortality records collated by the Office for National Statistics from Jan 2, 2017, to May 11, 2020. We identified the weekly number of deaths in people with type 1 and type 2 diabetes during the first 19 weeks of 2020 and calculated the percentage change from the mean number of deaths for the corresponding weeks in 2017, 2018, and 2019. The associations between risk factors (including sex, age, ethnicity, socioeconomic deprivation, HbA1c, renal impairment [from estimated glomerular filtration rate (eGFR)], BMI, tobacco smoking status, and cardiovascular comorbidities) and COVID-19-related mortality (defined as International Classification of Diseases, version 10, code U07.1 or U07.2 as a primary or secondary cause of death) between Feb 16 and May 11, 2020, were investigated by use of Cox proportional hazards models. Findings: Weekly death registrations in the first 19 weeks of 2020 exceeded the corresponding 3-year weekly averages for 2017–19 by 672 (50·9%) in people with type 1 diabetes and 16 071 (64·3%) in people with type 2 diabetes. Between Feb 16 and May 11, 2020, among 264 390 people with type 1 diabetes and 2 874 020 people with type 2 diabetes, 1604 people with type 1 diabetes and 36 291 people with type 2 diabetes died from all causes. Of these total deaths, 464 in people with type 1 diabetes and 10 525 in people with type 2 diabetes were defined as COVID-19 related, of which 289 (62·3%) and 5833 (55·4%), respectively, occurred in people with a history of cardiovascular disease or with renal impairment (eGFR <60 mL/min per 1·73 m2). Male sex, older age, renal impairment, non-white ethnicity, socioeconomic deprivation, and previous stroke and heart failure were associated with increased COVID-19-related mortality in both type 1 and type 2 diabetes. Compared with people with an HbA1c of 48–53 mmol/mol (6·5–7·0%), people with an HbA1c of 86 mmol/mol (10·0%) or higher had increased COVID-19-related mortality (hazard ratio [HR] 2·23 [95% CI 1·50–3·30, p<0·0001] in type 1 diabetes and 1·61 [1·47–1·77, p<0·0001] in type 2 diabetes). In addition, in people with type 2 diabetes, COVID-19-related mortality was significantly higher in those with an HbA1c of 59 mmol/mol (7·6%) or higher than in those with an HbA1c of 48–53 mmol/mol (HR 1·22 [95% CI 1·15–1·30, p<0·0001] for 59–74 mmol/mol [7·6–8·9%] and 1·36 [1·24–1·50, p<0·0001] for 75–85 mmol/mol [9·0–9·9%]). The association between BMI and COVID-19-related mortality was U-shaped: in type 1 diabetes, compared with a BMI of 25·0–29·9 kg/m2, a BMI of less than 20·0 kg/m2 had an HR of 2·45 (95% CI 1·60–3·75, p<0·0001) and a BMI of 40·0 kg/m2 or higher had an HR of 2·33 (1·53–3·56, p<0·0001); the corresponding HRs for type 2 diabetes were 2·33 (2·11–2·56, p<0·0001) and 1·60 (1·47–1·75, p<0·0001). Interpretation: Deaths in people with type 1 and type 2 diabetes rose sharply during the initial COVID-19 pandemic in England. Increased COVID-19-related mortality was associated not only with cardiovascular and renal complications of diabetes but, independently, also with glycaemic control and BMI

High Resolution Images of Orbital Motion in the Trapezium Cluster: First Scientific Results from the MMT Deformable Secondary Mirror Adaptive Optics System

We present the first scientific images obtained with a deformable secondary mirror adaptive optics system. We utilized the 6.5m MMT AO system to produce high-resolution (FWHM=0.07'') near infrared (1.6 um) images of the young (~1 Myr) Orion Trapezium theta 1 Ori cluster members. A combination of high spatial resolution and high signal to noise allowed the positions of these stars to be measured to within ~0.003'' accuracies. Including previous speckle data (Weigelt et al. 1999), we analyze a six year baseline of high-resolution observations of this cluster. Over this baseline we are sensitive to relative proper motions of only ~0.002''/yr (4.2 km/s at 450 pc). At such sensitivities we detect orbital motion in the very tight theta 1 Ori B2B3 (52 AU separation) and theta 1 Ori A1A2 (94 AU separation) systems. Such motions are consistent with those independently observed by Schertl et al. (2003) with speckle interferometry, giving us confidence that these very small (~0.002''/yr) orbital motions are real. All five members of the theta 1 Ori B system appear likely gravitationally bound. The very lowest mass member of the theta 1 Ori B system (B4) has K' ~11.66 and an estimated mass of ~0.2 Msun. There was very little motion (4+/-15 km/s) detected of B4 w.r.t B1 or B2, hence B4 is possibly part of the theta 1 Ori B group. We suspect that if this very low mass member is physically associated it most likely is in an unstable (non-hierarchical) orbital position and will soon be ejected from the group. The theta 1 Ori B system appears to be a good example of a star formation ``mini-cluster'' which may eject the lowest mass members of the cluster in the near future. This ``ejection'' process could play a major role in the formation of low mass stars and brown dwarfs.Comment: To appear in the December 10, 2003 issue of the Astrophysical Journal 21 pages, 14 figures (some in color, but print OK in B&W

Comprehensive and Integrated Genomic Characterization of Adult Soft Tissue Sarcomas

Sarcomas are a broad family of mesenchymal malignancies exhibiting remarkable histologic diversity. We describe the multi-platform molecular landscape of 206 adult soft tissue sarcomas representing 6 major types. Along with novel insights into the biology of individual sarcoma types, we report three overarching findings: (1) unlike most epithelial malignancies, these sarcomas (excepting synovial sarcoma) are characterized predominantly by copy-number changes, with low mutational loads and only a few genes (, , ) highly recurrently mutated across sarcoma types; (2) within sarcoma types, genomic and regulomic diversity of driver pathways defines molecular subtypes associated with patient outcome; and (3) the immune microenvironment, inferred from DNA methylation and mRNA profiles, associates with outcome and may inform clinical trials of immune checkpoint inhibitors. Overall, this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy number, methylation, RNA, and protein, providing insights into refining sarcoma therapy and relationships to other cancer types

Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome : Insights from the LUNG SAFE study

Publisher Copyright: © 2020 The Author(s). Copyright: Copyright 2020 Elsevier B.V., All rights reserved.Background: Concerns exist regarding the prevalence and impact of unnecessary oxygen use in patients with acute respiratory distress syndrome (ARDS). We examined this issue in patients with ARDS enrolled in the Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE (LUNG SAFE) study. Methods: In this secondary analysis of the LUNG SAFE study, we wished to determine the prevalence and the outcomes associated with hyperoxemia on day 1, sustained hyperoxemia, and excessive oxygen use in patients with early ARDS. Patients who fulfilled criteria of ARDS on day 1 and day 2 of acute hypoxemic respiratory failure were categorized based on the presence of hyperoxemia (PaO2 > 100 mmHg) on day 1, sustained (i.e., present on day 1 and day 2) hyperoxemia, or excessive oxygen use (FIO2 ≥ 0.60 during hyperoxemia). Results: Of 2005 patients that met the inclusion criteria, 131 (6.5%) were hypoxemic (PaO2 < 55 mmHg), 607 (30%) had hyperoxemia on day 1, and 250 (12%) had sustained hyperoxemia. Excess FIO2 use occurred in 400 (66%) out of 607 patients with hyperoxemia. Excess FIO2 use decreased from day 1 to day 2 of ARDS, with most hyperoxemic patients on day 2 receiving relatively low FIO2. Multivariate analyses found no independent relationship between day 1 hyperoxemia, sustained hyperoxemia, or excess FIO2 use and adverse clinical outcomes. Mortality was 42% in patients with excess FIO2 use, compared to 39% in a propensity-matched sample of normoxemic (PaO2 55-100 mmHg) patients (P = 0.47). Conclusions: Hyperoxemia and excess oxygen use are both prevalent in early ARDS but are most often non-sustained. No relationship was found between hyperoxemia or excessive oxygen use and patient outcome in this cohort. Trial registration: LUNG-SAFE is registered with ClinicalTrials.gov, NCT02010073publishersversionPeer reviewe