The Upland Gravels of the Mississippi River Valley and the Late Pliocene and Quaternary Deformation of the Reelfoot Rift

Neogene upland gravels of the Mississippi River valley have been interpreted to be terraces of the ancestral Mississippi and Tennessee River systems. The gravels are called the Citronelle Formation in Louisiana, Pre-loess gravels in Mississippi, Upland Complex in Tennessee and Arkansas, the Mounds and Grover in Illinois, and possibly the Windrow in Wisconsin, Iowa, and Minnesota. Large arcuate topographic lows in the upland gravels of northwestern Mississippi have been interpreted by previous investigators to be paleo-meanders of a large Pliocene Arc (Mississippi) River estimate to have had seven times the discharge of the modern Mississippi River and have had its headwaters in Canada. The present study explores that possibility by mapping gravel data from 97 wells in Illinois and gravel distributions of previous studies. The distribution of these Pliocene uplands gravels allows a partial reconstruction of the course of the Pliocene Arc River system and its elevation from central Minnesota to Memphis, Tennessee along the modern course of the Mississippi River. A longitudinal profile of the contoured surface of the base of the upland gravels was constructed and projected into southern Canada. This profile shows that the base of the Pliocene Arc River floodplain would be ~30 m above the modern ground surface and that the Arc River in Canada used to flow across Paleozoic strata that have been removed by glaciation. Within the northern Mississippi embayment 557 well logs reveal that the Pliocene Upland Complex of western Kentucky and Tennessee and Crowley\u27s Ridge in Arkansas has been displaced by east-striking normal faults. The normal faults extend east and west of the margins of the Reelfoot rift thus suggesting that right-lateral simple shear has extended from the Commerce geophysical lineament/fault to the Big Creek/Ellendale fault. Within this strain model north-striking stepover structures are interpreted to have experienced local east-west compression and the east-striking normal faults are a consequence of local north-south extension. The north-trending stepover structures have Quaternary uplift with uplift rates of 1-3 mm/yr

An investigation of the behavioral, normative, and control beliefs of college students who do not intend to possess a credit card: a reasoned action approach

Doctor of PhilosophyDepartment of Human Ecology-Personal Financial PlanningKristy L. Pederson-ArchuletaThe purpose of this dissertation was to examine the factors associated with students’ intentions to not possess and use a credit card. This dissertation focused on exploring a sample of undergraduate college students who do not possess a credit card. There is little known research on this group of students. The dissertation was directed by the following over-arching research question: The goal of this study was to explore college students’ beliefs about not possessing a credit card using the Theory of Reasoned Action (TRA). The research questions for this dissertation were: (a) How is personality (i.e., individual background factor) of undergraduate college students associated with their behavioral, normative, and control beliefs to not possess a credit card, (b) How are education level, age, gender, income level, religiosity, marital status, and ethnicity (i.e., social background factors) of undergraduate college students associated with their behavioral, normative, and control beliefs to not possess a credit card, and (c) How is financial knowledge (i.e., information background factor) of undergraduate college students associated with their behavioral, normative, and control beliefs to not possess a credit card. This study collected primary data. A pilot study was conducted to set the stage for the data collection of the current study. The data analysis methodology for this study consisted of the following four methods: (a) Factor Analysis, (b) Correlation Analysis, (c) MANOVA, and (d) Discriminant Function Analysis. Factor analysis identified questions were used to develop scales to measure the dependent variables. Strong reliability estimates were obtained, ranging from .84 to .94. The MANOVA test identified seven hypotheses with statistically significant results < .05. Control beliefs were significantly associated with personality. The five personality types, extraversion, agreeableness, conscientiousness, neuroticism, and openness, were all found to be significantly associated with either behavioral beliefs, control beliefs, or injunctive normative beliefs. Extraversion, agreeableness, conscientiousness, and neuroticism were all found to be associated with control beliefs. While agreeableness was also associated with injunctive normative beliefs, openness was found to be associated with behavioral beliefs. Financial knowledge was found to be associated with control beliefs. Discriminant function analysis was performed as a confirmatory test of the results from the MANOVA test, and supported the results of the MANOVA for six of the hypotheses

Letters To the Editor

Please allow me to introduce myself to you: my name is G. William Rubagumya, an attorney in the state of Texas in the USA. I am originally from the country of Rwanda via the refugee camps of Uganda and I have been in the USA for the last 7 years. As you may have guessed, my concern is with the refugees that I left behind both in Ugan- da and other surrounding countries. Myself and other Rwandans in this country have formed a nonprofit organization, The Tutsi Relief Founda- tion Inc., whose main purpose is to aid in any way possible, but with primary emphasis on education and relocation of those who are able to adapt to the changed environment

Evaluation of exposure-specific risks from two independent samples: A simulation study

<p>Abstract</p> <p>Background</p> <p>Previous studies have proposed a simple product-based estimator for calculating exposure-specific risks (ESR), but the methodology has not been rigorously evaluated. The goal of our study was to evaluate the existing methodology for calculating the ESR, propose an improved point estimator, and propose variance estimates that will allow the calculation of confidence intervals (CIs).</p> <p>Methods</p> <p>We conducted a simulation study to test the performance of two estimators and their associated confidence intervals: 1) current (simple product-based estimator) and 2) proposed revision (revised product-based estimator). The first method for ESR estimation was based on multiplying a relative risk (RR) of disease given a certain exposure by an overall risk of disease. The second method, which is proposed in this paper, was based on estimates of the risk of disease in the unexposed. We then multiply the updated risk by the RR to get the revised product-based estimator. A log-based variance was calculated for both estimators. Also, a binomial-based variance was calculated for the revised product-based estimator. 95% CIs were calculated based on these variance estimates. Accuracy of point estimators was evaluated by comparing observed relative bias (percent deviation from the true estimate). Interval estimators were evaluated by coverage probabilities and expected length of the 95% CI, given coverage. We evaluated these estimators across a wide range of exposure probabilities, disease probabilities, relative risks, and sample sizes.</p> <p>Results</p> <p>We observed more bias and lower coverage probability when using the existing methodology. The revised product-based point estimator exhibited little observed relative bias (max: 4.0%) compared to the simple product-based estimator (max: 93.9%). Because the simple product-based estimator was biased, 95% CIs around this estimate exhibited small coverage probabilities. The 95% CI around the revised product-based estimator from the log-based variance provided better coverage in most situations.</p> <p>Conclusion</p> <p>The currently accepted simple product-based method was only a reasonable approach when the exposure probability is small (< 0.05) and the RR is ≤ 3.0. The revised product-based estimator provides much improved accuracy.</p

Development of a unidimensional composite measure of neuropsychological functioning in older cardiac surgery patients with good measurement precision

The objective of this analysis was to develop a measure of neuropsychological performance for cardiac surgery and to assess its psychometric properties. Older patients (n = 210) underwent a neuropsychological battery using nine assessments. The number of factors was identified with variable reduction methods. Factor analysis methods based on item response theory were used to evaluate the measure. Modified parallel analysis supported a single factor, and the battery formed an internally consistent set (coefficient alpha = .82). The developed measure provided a reliable, continuous measure (reliability > .90) across a broad range of performance (–1.5 SDs to +1.0 SDs) with minimal ceiling and floor effects

Attenuation of microvascular function in those with cardiovascular disease is similar in patients of Indian Asian and European descent

addresses: Institute of Biomedical and Clinical Science, Peninsula Medical School (Exeter), University of Exeter, UK. [email protected]: PMCID: PMC2823616types: Comparative Study; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't© 2010 Strain et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Indian Asians are at increased risk of cardiovascular death which does not appear to be explained by conventional risk factors. As microvascular disease is also more prevalent in Indian Asians, and as it is thought to play a role in the development of macrovascular disease, we decided to determine whether impaired microcirculation could contribute to this increased cardiovascular risk in Indian Asians

Genetic Analysis Workshop 15: gene expression analysis and approaches to detecting multiple functional loci

National Institutes of Health (AR44422, N01-AR-7-2232, 5R01-HL049609-14, IR01-AG021917-01A1); Genome Canada and Associations AFP; Polyarctique-Groupe Taitbout; Rhumatisme et Travail; Arthritis Research Campaign; Unversity of Minnesota; Minnesota Supercomputing Institute; National Institute of General Medical Sciences (R01 GM31575

Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score

Background Identifying individuals at risk for developing Alzheimer disease (AD) is of utmost importance. Although genetic studies have identified AD-associated SNPs in APOE and other genes, genetic information has not been integrated into an epidemiological framework for risk prediction. Methods and findings Using genotype data from 17,008 AD cases and 37,154 controls from the International Genomics of Alzheimer’s Project (IGAP Stage 1), we identified AD-associated SNPs (at p < 10−5 ). We then integrated these AD-associated SNPs into a Cox proportional hazard model using genotype data from a subset of 6,409 AD patients and 9,386 older controls from Phase 1 of the Alzheimer’s Disease Genetics Consortium (ADGC), providing a polygenic hazard score (PHS) for each participant. By combining population-based incidence rates and the genotype-derived PHS for each individual, we derived estimates of instantaneous risk for developing AD, based on genotype and age, and tested replication in multiple independent cohorts (ADGC Phase 2, National Institute on Aging Alzheimer’s Disease Center [NIA ADC], and Alzheimer’s Disease Neuroimaging Initiative [ADNI], total n = 20,680). Within the ADGC Phase 1 cohort, individuals in the highest PHS quartile developed AD at a considerably lower age and had the highest yearly AD incidence rate. Among APOE ε3/3 individuals, the PHS modified expected age of AD onset by more than 10 y between the lowest and highest deciles (hazard ratio 3.34, 95% CI 2.62–4.24, p = 1.0 × 10−22). In independent cohorts, the PHS strongly predicted empirical age of AD onset (ADGC Phase 2, r = 0.90, p = 1.1 × 10−26) and longitudinal progression from normal aging to AD (NIA ADC, Cochran–Armitage trend test, p = 1.5 × 10−10), and was associated with neuropathology (NIA ADC, Braak stage of neurofibrillary tangles, p = 3.9 × 10−6 , and Consortium to Establish a Registry for Alzheimer’s Disease score for neuritic plaques, p = 6.8 × 10−6 ) and in vivo markers of AD neurodegeneration (ADNI, volume loss within the entorhinal cortex, p = 6.3 × 10−6 , and hippocampus, p = 7.9 × 10−5 ). Additional prospective validation of these results in non-US, non-white, and prospective community-based cohorts is necessary before clinical use. Conclusions We have developed a PHS for quantifying individual differences in age-specific genetic risk for AD. Within the cohorts studied here, polygenic architecture plays an important role in modifying AD risk beyond APOE. With thorough validation, quantification of inherited genetic variation may prove useful for stratifying AD risk and as an enrichment strategy in therapeutic trials

Meta-analysis of 49 549 individuals imputed with the 1000 Genomes Project reveals an exonic damaging variant in ANGPTL4 determining fasting TG levels

Background So far, more than 170 loci have been associated with circulating lipid levels through genomewide association studies (GWAS). These associations are largely driven by common variants, their function is often not known, and many are likely to be markers for the causal variants. In this study we aimed to identify more new rare and low-frequency functional variants associated with circulating lipid levels. Methods We used the 1000 Genomes Project as a reference panel for the imputations of GWAS data from ~60 000 individuals in the discovery stage and ~90 000 samples in the replication stage. Results Our study resu