Disjunctivism and the possibility of perceptual knowledge

This thesis is about one of John McDowell’s epistemic arguments for perceptual disjunctivism. According to the argument in question we can know things on the basis of perception only if perceptions provide us with different epistemic reasons than phenomenally indistinguishable hallucinations and this is possible only if perceptions have mind-independent states of the world as constituents and are hence a different kind of experiential state from hallucinations, as the perceptual disjunctivist suggests. I argue against some detractors that there is an argument with this structure to be found in McDowell’s writings. I then argue that McDowell’s own version of the argument fails because it relies on commitments to certain theses which generate problems for the argument. I then describe an alternative version of the argument. The alternative version of the argument relies on a distinctive theory of what it is for perceptions to provide their subjects with epistemic reasons. According to this theory, perceptions are not themselves reasons to believe things about the world but enable us to possess reasons which are then thought of as the states of the world they relate us to: perceptions are not reasons but are ways of possessing reasons. I attempt to develop this theory, defend it against some objections, and I argue that if it is correct then the epistemic argument can be got to work without any commitment to the problematic theses McDowell’s version of the argument commits itself to

Separability of Rotational Effects on a Gravitational Lens

We derive the deflection angle up to $O(m^2a)$ due to a Kerr gravitational lens with mass $m$ and specific angular momentum $a$. It is known that at the linear order in $m$ and $a$ the Kerr lens is observationally equivalent to the Schwarzschild one because of the invariance under the global translation of the center of the lens mass. We show, however, nonlinear couplings break the degeneracy so that the rotational effect becomes in principle separable for multiple images of a single source. Furthermore, it is distinguishable also for each image of an extended source and/or a point source in orbital motion. In practice, the correction at $O(m^2a)$ becomes $O(10^{-10})$ for the supermassive black hole in our galactic center. Hence, these nonlinear gravitational lensing effects are too small to detect by near-future observations.Comment: 12 pages (RevTeX); accepted for publication in Phys. Rev.

Cloud-Based Speech Technology for Assistive Technology Applications (CloudCAST)

The CloudCAST platform provides a series of speech recognition services that can be integrated into assistive technology applications. The platform and the services provided by the public API are described. Several exemplar applications have been developed to demonstrate the platform to potential developers and users

Elite male Flat jockeys display lower bone density and lower resting metabolic rate than their female counterparts: implications for athlete welfare

To test the hypothesis that daily weight-making is more problematic to health in male compared with female jockeys, we compared the bone-density and resting metabolic rate (RMR) in weight-matched male and female Flat-jockeys. RMR (kcal.kg-1 lean mass) was lower in males compared with females as well as lower bone-density Z-scores at the hip and lumbar spine. Data suggest the lifestyle of male jockeys’ compromise health more severely than females, possibly due to making-weight more frequently

Emergence of Anti-Cancer Drug Resistance: Exploring the Importance of the Microenvironmental Niche via a Spatial Model

Practically, all chemotherapeutic agents lead to drug resistance. Clinically, it is a challenge to determine whether resistance arises prior to, or as a result of, cancer therapy. Further, a number of different intracellular and microenvironmental factors have been correlated with the emergence of drug resistance. With the goal of better understanding drug resistance and its connection with the tumor microenvironment, we have developed a hybrid discrete-continuous mathematical model. In this model, cancer cells described through a particle-spring approach respond to dynamically changing oxygen and DNA damaging drug concentrations described through partial differential equations. We thoroughly explored the behavior of our self-calibrated model under the following common conditions: a fixed layout of the vasculature, an identical initial configuration of cancer cells, the same mechanism of drug action, and one mechanism of cellular response to the drug. We considered one set of simulations in which drug resistance existed prior to the start of treatment, and another set in which drug resistance is acquired in response to treatment. This allows us to compare how both kinds of resistance influence the spatial and temporal dynamics of the developing tumor, and its clonal diversity. We show that both pre-existing and acquired resistance can give rise to three biologically distinct parameter regimes: successful tumor eradication, reduced effectiveness of drug during the course of treatment (resistance), and complete treatment failure

Biosynthesis of ganglioside mimics in Campylobacter jejuni OH4384. Identification of the glycosyltransferase genes, enzymatic synthesis of model compounds, and characterization of nanomole amounts by 600-mhz (1)h and (13)c NMR analysis.

We have applied two strategies for the cloning of four genes responsible for the biosynthesis of the GT1a ganglioside mimic in the lipooligosaccharide (LOS) of a bacterial pathogen,Campylobacter jejuni OH4384, which has been associated with Guillain-Barre syndrome. We first cloned a gene encoding an α-2,3-sialyltransferase (cst-I) using an activity screening strategy. We then used nucleotide sequence information from the recently completed sequence from C. jejuni NCTC 11168 to amplify a region involved in LOS biosynthesis from C. jejuni OH4384. The LOS biosynthesis locus from C. jejuni OH4384 is 11.47 kilobase pairs and encodes 13 partial or complete open reading frames, while the corresponding locus in C. jejuni NCTC 11168 spans 13.49 kilobase pairs and contains 15 open reading frames, indicating a different organization between these two strains. Potential glycosyltransferase genes were cloned individually, expressed in Escherichia coli, and assayed using synthetic fluorescent oligosaccharides as acceptors. We identified genes encoding a β-1,4-N-acetylgalactosaminyl-transferase (cgtA), a β-1,3-galactosyltransferase (cgtB), and a bifunctional sialyltransferase (cst-II), which transfers sialic acid to O-3 of galactose and to O-8 of a sialic acid that is linked α-2,3- to a galactose. The linkage specificity of each identified glycosyltransferase was confirmed by NMR analysis at 600 MHz on nanomole amounts of model compounds synthesized in vitro. Using a gradient inverse broadband nano-NMR probe, sequence information could be obtained by detection of3J(C,H) correlations across the glycosidic bond. The role of cgtA and cst-II in the synthesis of the GT1a mimic in C. jejuni OH4384 were confirmed by comparing their sequence and activity with corresponding homologues in two relatedC. jejuni strains that express shorter ganglioside mimics in their LOS

Giant magnetoresistance of multiwall carbon nanotubes: modeling the tube/ferromagnetic-electrode burying contact

We report on the giant magnetoresistance (GMR) of multiwall carbon nanotubes with ultra small diameters. In particular, we consider the effect of the inter-wall interactions and the lead/nanotube coupling. Comparative studies have been performed to show that in the case when all walls are well coupled to the electrodes, the so-called inverse GMR can appear. The tendency towards a negative GMR depends on the inter-wall interaction and on the nanotube le ngth. If, however, the inner nanotubes are out of contact with one of the electrodes, the GMR remains positive even for relatively strong inter-wall interactions regardless of the outer nanotube length. These results shed additional light on recently reported experimental data, where an inverse GMR was found in some multiwall carbon nanotube samples.Comment: 5 pages, 5 figure