4,079 research outputs found
A narrativa na arte digital
Nesta comunicação vai falar-se da Narrativa como forma de contar histórias e da sua evolução até à interactividade na Arte Digital. A sua importância e influência, no design e desenvolvimento de artefactos interactivos e videojogos apelativos ao utilizador. Estudo de caso do projecto Autómato Disserto. A aplicação da Narrativa Interactiva, descrição, funcionamento, resultados e conclusão.Fundação para a Ciência e a Tecnologia (FCT
Do hereditary syndrome-related gynecologic cancers have any specific features?
Hereditary syndromes are responsible for 10 % of
gynaecologic cancers, among which hereditary breastovarian
cancer and hereditary non-polyposis colon cancer
syndromes, known as HBOC and Lynch syndromes respectively,
present the highest relative risk. The latter predisposes
to endometrial cancer and both contribute to
ovarian cancer. Cowden syndrome-related endometrial cancer
and the increased risk of ovarian, uterine and cervical
cancers associated with Peutz-Jeghers syndrome, are also
demonstrated, while Li-Fraumeni syndrome patients are
prone to develop ovarian and endometrial cancers. Despite
these syndromes’ susceptibility to gynaecologic cancers
being consensual, it is still not clear whether these tumours
have any epidemiologic, clinical, pathologic or imaging
specific features that could allow any of the intervening
physicians to raise suspicion of a hereditary syndrome
in patients without known genetic risk. Moreover,
controversy exists regarding both screening and surveillance
schemes. Our literature review provides an updated
perspective on the evidence-based specific features of tumours
related to each of these syndromes as well as on
the most accepted screening and surveillance guidelines. In
addition, some illustrative cases are presented
Inibidores da bomba de protões e o risco de eventos adversos graves : uma bomba cardiovascular?
© 2018 Sociedade Portuguesa de Cardiologia. Published by Elsevier España, S.L.U. This is an
Open Access article under the CC BY-NC-ND license.Proton pump inhibitors are currently one of the most prescribed pharmacological classes in developed countries, given their effectiveness and safety profile, which has until now been considered favorable. However, in recent years, several papers have been published that associate prolonged use of these drugs with a wide range of adverse effects, posing doubts about their safety. Among the adverse effects described is an increased risk of cardiovascular events. This relationship was first described in subjects after acute coronary syndrome due to the interference of proton pump inhibitors in the cytochrome P450 2C19 and the conversion of clopidogrel to its active metabolite. More recent studies have also reported this relationship with the use of antiplatelet agents that do not depend on cytochrome P450 2C19 activation. The proposed mechanism is inhibition of dimethylarginine dimethylaminohydrolase, a physiological inhibitor of asymmetric dimethylarginine, which increases plasma concentrations of the latter enzyme, leading to lower levels of nitric oxide. By reviewing in this article the relationship between the use of proton pump inhibitors and increased risk of cardiovascular and cerebrovascular events, the authors aim to alert the medical community to the potentially harmful effects of these drugs, and recommend the setting of a moratorium on their prolonged use.info:eu-repo/semantics/publishedVersio
Co-design and mass customization in the Portuguese footwear cluster: an exploratory study
In the present, consumers tend to be more knowledgeable and interventive, requiring an active role in the way how they relate to brands and products. To meet this need, several sectors of the fashion industry saw this as a market opportunity and adopted approaches of Collaborative Design and Mass Customization. The footwear sector was not indifferent to this new paradigm of creation, production, distribution, and consumption, and several worldwide brands adopted innovative strategies. In Portugal, despite footwear being a mature industry with a strong tradition and worldwide recognition, it is necessary to continuously invest in innovation-based competitiveness, exploring the opportunities of Industry 4.0. Thus, the study seeks to analyse this important sector of the Portuguese economy, in order to perceive the acceptance, vision, and expectations regarding the approaches of Co-design and Mass Customization. In this way, seven companies with national relevance were studied based on a questionnaire survey. Findings show the industry's interest in Co-design and customization, despite the concern about the effort and risk associated to the transition and implementation of the productive approach. Relevant data for the development of collaborative models of footwear customization are gathered in this study.This work is supported by Project UID/CTM/00264/2019 of 2C2T – Centre for Textile Science and Technology, funded by National Founds through FCT/MCTES and by FAMEST Project (projeto de IDT em co-promoção mobilizador n. 24529, 2017-2020)
Wireless technologies for Controlling a Traffic Lights Prototype
This paper presents a traffic light control system based on wireless communication technologies. Traffic density is increasing at an alarming rate in developing countries which calls for intelligent dynamic traffic light control systems to replace the conventional manual and time based ones. The approach followed in this paper is based in a secure wireless sensor network to feed real time data to the intelligent traffic light control. A physical prototype was implemented for experimental validation. The physical prototype showed robustness against local failures or unforeseen cases showing that the communication between modules keeps an acceptable packets received ratio
Upgrading a legacy manufacturing cell to IoT
Many industries, like aeronauting construction are still equipped with legacy machines and are not keen to change old, however fully functional, equipment to new ones. Hence, an upgrade must be found to cope the legacy and fully functional machines to IOT technologies. This paper is a contribution to embrace those challenges in a new IoT architecture able to support the creation of solutions for Smart Industries. Internet of Things is increasing acceptance and the infrastructure for them is becoming available. This leads to an insurgence on investments and development of new dedicated IoT infrastructures. Industries need to adapt quickly to this constant technological evolution, implementing measures and connecting machines and robots at critical points to the Internet, instrumenting them using the concept of IoT, with the major goal of implementing a flexible, secure, easy to maintain and capable to evolve infrastructure, when legacy equipment is involved. The availability of machines and other critical assets directly affects the effectiveness of manufacturing operations. The architecture design offers security, flexibility, simplicity of implementation and maintenance, and is resilient to failures or attacks and technologically independent. Field tests are reported to evaluate key aspects of the proposed architecture
Traffic Light Using Multiple Wireless Technologies
This paper presents the study and experimental tests for the viability analysis of using multiple wireless technologies in urban traffic light controllers in a Smart City environment.
Communication drivers, different types of antennas, data acquisition methods and data processing for monitoring the network are presented. The sensors and actuators modules are connected in a local area network through two distinct low power wireless networks using both 868 MHz and 2.4 GHz frequency bands. All data communications using 868 MHz go through a Moteino. Various tests are made to assess the most advantageous features of each communication type. The experimental results show better range for 868 MHz solutions,
whereas the 2.4 GHz presents the advantage of self-regenerating the network and mesh. The different pros and cons of both communication methods are presented
Wireless networks for traffic light control on urban and aerotropolis roads
This paper presents a traffic lights system based on wireless communication, providing a support infrastructure for intelligent control in smart cities and aerotropolis scope. An aerotropolis is a metropolitan subregion which infrastructure is centered around an airport [1]. Traffic intensity is increasing all over the world. Intelligent dynamic traffic lights system control are sought for replacing classic conventional manual and time based systems. In this work a wireless sensors network is designed and implemented to feed real time data to the intelligent traffic lights systems control. A physical prototype is implemented for experimental validation outside laboratory environment. The physical prototype shows robustness against unexpected issues or local failures. Results are positive in the scope of the experiences made and promising in terms of extending the tests to larger areas
Valores de referência de alguns elementos-traço em solos intemperizados da região Norte brasileira
Solos formados a partir de sedimentos do Grupo Barreiras apresentam, em geral, baixos teores de ferro, mineralogia caulinítica, elevadas quantidades de quartzo na fração areia e pequena quantidade de carbono orgânico. Determinaram-se os teores de Cd, Co, Cr, Ni e Zn extraídos com água régia, em bloco digestor, em Argissolos Amarelos e Latossolos Amarelos sob vegetação natural do Pará e Amapá. Regressão linear múltipla foi utilizada para correlacionar os parâmetros de solo e os teores desses metais. Melhores correlações foram obtidas entre Fe, Mn, argila, silte e Cd, Co, Cu, Zn, Cr, Ni. Não foi encontrada correlação entre o pH e os teores de metais. Argila e areia apresentaram correlação inversa com os metais, porém de mesma magnitude, sendo necessária a exclusão de uma delas no modelo de regressão. Em geral, os teores dos elementos estudados foram inferiores aos encontrados em solos formados a partir de outros materiais de origem. O Mn foi incluído no modelo de regressão linear múltipla do Cd e Co, em função de sua associação com esses metais. O silte foi significativo nas equações para Cr e Co, o que pode ser devido à presença de minerais de argila e óxidos de Fe e Mn em agregados ferruginosos e argilosos de tamanho silte. Estas equações podem ser úteis quando se deseja conhecer, em termos gerais, quais as quantidades que determinada amostra teria se o solo em questão não estivesse contaminado ou sujeito a uso antrópico, podendo ser utilizadas na avaliação da contaminação do solo por estes metais.Soils formed from the Barreiras Group sediments, located mainly along the coast of Brazil Northern and Northeastern regions, generally present low concentrations of iron oxides and total organic carbon, high quantities of quartz in the sand fraction, and kaolinitic clay mineralogy. The objective of the present study was to quantify the pseudo total concentrations of Cd, Co, Cu, Cr, Mn, Ni, Zn and Fe in Xhantic Udox and Xhantic Udult soils derived from these sediments. The reference sites were covered by native vegetation and located in the States of Pará and Amapá, Brazil. Multiple linear regression analysis was applied to determine correlations between soil parameters and the levels of these metals. The best correlation was obtained between Fe, Mn, clay, and silt contents, and Cd, Co, Cu, Zn, Cr, Ni. A correlation between pH and these metal levels was not found. Clay and sand contents showed a negative inverse correlation with the metal levels,of same magnitude but with a different sign; this was the reason for excluding one of the parameters in the regression model. In general, the contents of the elements were lower than those found in soils formed from other parent materials. The Mn content was included in the model of multiple linear regression for Cd and Co, due to its association with these last metals. Silt level showed to have a significant influence in the equations for Cr and Co, which is attributed to the presence of clay minerals and Fe and Mn oxides in ferruginous and clay aggregates of silt size. The equations obtained in this paper, are useful to predict, in general terms, the amounts of those heavy metals in an unknown soil sample, if the soil material were not contaminated or affected by land usage. Thus, they may be applied to evaluate soil contamination by the studied heavy metals
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