347 research outputs found
Sterile neutrinos as subdominant warm dark matter
In light of recent findings which seem to disfavor a scenario with (warm)
dark matter entirely constituted of sterile neutrinos produced via the
Dodelson-Widrow (DW) mechanism, we investigate the constraints attainable for
this mechanism by relaxing the usual hypothesis that the relic neutrino
abundance must necessarily account for all of the dark matter. We first study
how to reinterpret the limits attainable from X-ray non-detection and
Lyman-alpha forest measurements in the case that sterile neutrinos constitute
only a fraction fs of the total amount of dark matter. Then, assuming that
sterile neutrinos are generated in the early universe solely through the DW
mechanism, we show how the X-ray and Lyman-alpha results jointly constrain the
mass-mixing parameters governing their production. Furthermore, we show how the
same data allow us to set a robust upper limit fs < 0.7 at the 2 sigma level,
rejecting the case of dominant dark matter (fs = 1) at the ~ 3 sigma level.Comment: Minor changes; added references; version accepted for publication in
Phys. Rev.
Uncovering GEMS of Mathematics
Gateway to Exploring Mathematical Sciences (GEMS) is an outreach program offered by the six mathematics departments of the Claremont Colleges for eighth, ninth, and tenth graders. In this paper, we describe our program (in terms of format, participants, mathematical activities and topics involved) and share why we are so enthusiastic about it
mRNA export and cancer
This PhD focuses on the relationship between mRNA export and cancer
Evolution of an elliptical bubble in an accelerating extensional flow
Mathematical models that describe the dynamical behavior of a thin gas bubble embedded in a glass fiber during a fiber drawing process have been discussed and analyzed.
The starting point for the mathematical modeling was the equations presented in [1] for a glass fiber with a hole undergoing extensional flow. These equations were reconsidered here with the additional reduction that the hole, i.e. the gas bubble, was thin as compared to the radius of the fiber and of finite extent. The primary model considered was one in which the mass of the gas inside the bubble was fixed. This fixed-mass model involved equations for the axial velocity and fiber radius, and equations for the radius of the bubble and the gas pressure inside the bubble. The model equations assumed that the temperature of the furnace of the drawing tower was known.
The governing equations of the bubble are hyperbolic and predict that the bubble cannot extend beyond the limiting characteristics specified by the ends of the initial bubble shape. An analysis of pinch-off was performed, and it was found that pinch-off can occur, depending on the parameters of the model, due to surface tension when the bubble radius is small.
In order to determine the evolution of a bubble, a numerical method of solution was presented. The method was used to study the evolution of two different initial bubble shapes, one convex and the other non-convex. Both initial bubble shapes had fore-aft symmetry, and it was found that the bubbles stretched and elongated severely during the drawing process. For the convex shape, fore-aft symmetry was lost in the middle of the drawing process, but the symmetry was re-gained by the end of the drawing tower. A small amount of pinch-off was observed at each end for this case, so that the final bubble length was slightly shorter than its theoretical maximum length. For the non-convex initial shape, pinch-off occurred in the middle of the bubble resulting in two bubbles by the end of the fiber draw.
The two bubbles had different final pressures and did not have fore-aft symmetry.
An extension of the fixed-mass model was considered in which the gas in the bubble was allowed to diffuse into the surrounding glass. The governing equations for this leaky-mass model were developed and manipulated into a form suitable for a numerical treatment
Analysis of galactic tides and stars on CDM microhalos
A special purpose N-body simulation has been built to understand the tidal
heating of the smallest dark matter substructures (10^{-6}\msun and 0.01pc)
from the grainy potential of the Milky Way due to individual stars in the disk
and the bulge. To test the method we first run simulations of single encounters
of microhalos with an isolated star, and compare with analytical predictions of
the dark particle bound fraction as a function of impact parameter. We then
follow the orbits of a set of microhalos in a realistic flattened Milky Way
potential. We concentrate on (detectable) microhalos passing near the Sun with
a range of pericenter and apocenter. Stellar perturbers near the orbital path
of a microhalo would exert stochachstic impulses, which we apply in a Monte
Carlo fashion according to the Besancon model for the distribution of stars of
different masses and ages in our Galaxy. Also incorporated are the usual
pericenter tidal heating and disk-shocking heating. We give a detailed
diagnosis of typical microhalos and find microhalos with internal tangential
anisotropy are slightly more robust than the ones with radial anisotropy. In
addition, the dark particles generally go through of a random walk in velocity
space and diffuse out of the microhalos.
We show that the typical destruction time scales are strongly correlated with
the stellar density averaged along a microhalo's orbit over the age of the
stellar disk. We also present the morphology of a microhalo at several epochs
which may hold the key to dark matter detections.Comment: 15 pages, 12 figure
Z(2)-Singlino Dark Matter in a Portal-Like Extension of the Minimal Supersymmetric Standard Model.
We propose a Z2-stabilized singlino () as a dark matter candidate in extended and R-parity violating versions of the supersymmetric standard model. interacts with visible matter via a heavy messenger field S, which results in a supersymmetric version of the Higgs portal interaction. The relic abundance of can account for cold dark matter if the messenger mass satisfies GeV. Our model can be implemented in many realistic supersymmetric models such as the next-to-minimal supersymmetric (SUSY) standard model and nearly minimal SUSY standard model
Systematic effects in the extraction of the 'WMAP haze'
The extraction of a 'haze' from the WMAP microwave skymaps is based on
subtraction of known foregrounds, viz. free-free (bremsstrahlung), thermal dust
and synchrotron, each traced by other skymaps. While the 408 MHz all-sky survey
is used for the synchrotron template, the WMAP bands are at tens of GHz where
the spatial distribution of the radiating cosmic ray electrons ought to be
quite different because of the energy-dependence of their diffusion in the
Galaxy. The systematic uncertainty this introduces in the residual skymap is
comparable to the claimed haze and can, for certain source distributions, have
a very similar spectrum and latitudinal profile and even a somewhat similar
morphology. Hence caution must be exercised in interpreting the 'haze' as a
physical signature of, e.g., dark matter annihilation in the Galactic centre.Comment: 17 pages, 12 figures; improved diffusion model; extended discussion
of spectral index maps; clarifying comments, figures and references added; to
appear in JCA
Evidence-based clinical practice guidelines on the management of pain in older people - a summary report.
OBJECTIVE: The objective of this study is to develop an update of the evidence-based guidelines for the management of pain in older people. DESIGN: Review of evidence since 2010 using a systematic and consensus approach is performed. RESULTS: Recognition of the type of pain and routine assessment of pain should inform the use of specific environmental, behavioural and pharmacological interventions. Individualised care plans and analgesic protocols for specific clinical situations, patients and health care settings can be developed from these guidelines. CONCLUSION: Management of pain must be considered as an important component of the health care provided to all people, regardless of their chronological age or severity of illness. By clearly outlining areas where evidence is not available, these guidelines may also stimulate further research. To use the recommended therapeutic approaches, clinicians must be familiar with adverse effects of treatment and the potential for drug interactions
Violence and vulnerability:Children’s strategies and the logic of violence in Burundi
This study explores how children in conflict-affected Burundi deal with violence in their everyday lives. Focusing on schools as a context in which children are prepared for further roles in society, child-centred, qualitative and mixed-methods research was conducted at 36 primary schools throughout Burundi. Findings reveal that children use a variety of strategies to deal with violence they encounter. These strategies reflect a learned 'logic of violence', matching dynamics of violence and vulnerability in society at large. Children's strategies are ultimately aimed at reducing vulnerability to (future) violence and indicative of the omnipresence of violence and uncertainty in Burundi. (C) 2019 The Authors. Children & Society published by National Children's Bureau and John Wiley & Sons LtdPublic Health and primary car
Deconstructing, Addressing, and Eliminating Racial and Ethnic Inequities in Prostate Cancer Care
Context
Men of African ancestry have demonstrated markedly higher rates of prostate cancer mortality than men of other races and ethnicities around the world. In fact, the highest rates of prostate cancer mortality worldwide are found in the Caribbean and Sub-Saharan West Africa, and among men of African descent in the USA. Addressing this inequity in prostate cancer care and outcomes requires a focused research approach that creates durable solutions to address the structural, social, environmental, and health factors that create racial disparities in care and outcomes.
Objective
To introduce a conceptual model for evaluating racial inequities in prostate cancer care to facilitate the development of translational research studies and interventions.
Evidence acquisition
A collaborative review of literature relevant to racial inequities in prostate cancer care and outcomes was performed. Existing literature was used to highlight various components of the conceptual model to inform future research and interventions toward equitable care and outcomes.
Evidence synthesis
Racial inequities in prostate cancer outcomes are driven by a series of structural and social determinants of health that impact exposures, mediators, and outcomes. Social determinants of equity, such as laws/policies, economic systems, and structural racism, affect the inequitable access to environmental and neighborhood exposures, in addition to health care access. Although the incidence disparity remains problematic, various studies have demonstrated parity in outcomes when social and health factors, such as access to equitable care, are normalized. Few studies have tested interventions to reduce inequities in prostate cancer among Black men.
Conclusions
Worldwide, men of African ancestry demonstrate worse outcomes in prostate cancer, a phenomenon driven largely by social factors that inform biologic, environmental, and health care risks. A conceptual model was presented that organizes the many factors that influence prostate cancer incidence and mortality. Within that framework, we must understand the current state of inequities in clinical prostate cancer practice, the optimal state of what equitable practice would be, and how achieving equity in prostate cancer care balances costs, benefits, and harms. More robust characterization of the sources of prostate cancer inequities should inform testing of ambitious and innovative interventions as we work toward equity in care and outcomes.
Patient summary
Men of African ancestry demonstrate the highest rates of prostate cancer mortality, which may be reduced through social interventions. We present a framework for formalizing the identification of the drivers of prostate cancer inequities to facilitate the development of interventions and trials to eradicate them
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