INSPECTION AND MAINTENANCE EXPERIENCE WITH HRE-2

Experience in replacement of highly radioactive components of Homogeneous Reactor Experiment No. 2 is discussed, with particular emphasis on containment of air-bonne contamination and control of personnel exposure. The design and operation of tools and viewing devices developed to observe the hole in the HRE-2 core tank are described. (auth

Multiple Projection Optical Diffusion Tomography with Plane Wave Illumination

We describe a new data collection scheme for optical diffusion tomography in which plane wave illumination is combined with multiple projections in the slab imaging geometry. Multiple projection measurements are performed by rotating the slab around the sample. The advantage of the proposed method is that the measured data can be much more easily fitted into the dynamic range of most commonly used detectors. At the same time, multiple projections improve image quality by mutually interchanging the depth and transverse directions, and the scanned (detection) and integrated (illumination) surfaces. Inversion methods are derived for image reconstructions with extremely large data sets. Numerical simulations are performed for fixed and rotated slabs

Walking the walk: a phenomenological study of long distance walking

Evidence suggests that regular walking can elicit significant psychological benefits although little evidence exists concerning long distance walking. The purpose of this study was to provide detailed accounts of the experiences of long distance walkers. Phenomenological interviews were conducted with six long distance walkers. Data were transcribed verbatim before researchers independently analyzed the transcripts. Participants reported a cumulative effect with positive feelings increasing throughout the duration of the walk. Long distance walking elicited positive emotions, reduced the effects of life-stress, and promoted an increased sense of well-being and personal growth. Results are aligned to theories and concepts from positive psychology

Review: Animal model and the current understanding of molecule dynamics of adipogenesis

Among several potential animal models that can be used for adipogenic studies, Wagyu cattle is the one that presents unique molecular mechanisms underlying the deposit of substantial amounts of intramuscular fat. As such, this review is focused on current knowledge of such mechanisms related to adipose tissue deposition using Wagyu cattle as model. So abundant is the lipid accumulation in the skeletal muscles of these animals that in many cases, the muscle cross-sectional area appears more white (adipose tissue) than red (muscle fibers). This enhanced marbling accumulation is morphologically similar to that seen in numerous skeletal muscle dysfunctions, disease states and myopathies; this might indicate cross-similar mechanisms between such dysfunctions and fat deposition in Wagyu breed. Animal models can be used not only for a better understanding of fat deposition in livestock, but also as models to an increased comprehension on molecular mechanisms behind human conditions. This revision underlies some of the complex molecular processes of fat deposition in animals

The influence of distributed leadership on teachers' organizational commitment: a multilevel approach

In the present study the effects of a cooperative leadership team, distributed leadership, participative decision-making, and context variables on teachers' organizational commitment are investigated. Multilevel analyses on data from 1522 teachers indicated that 9% of the variance in teachers' organizational commitment is attributable to differences between schools. The analyses revealed that especially the presence of a cooperative leadership team and the amount of leadership support played a significantly positive key role in predicting teachers' organizational commitment. Also, participative decision-making and distribution of the supportive leadership function had a significant positive impact on teachers' organizational commitment. In contrast, distribution of the supervisory leadership function and teachers' job experience had a significant negative impact

Keith County, Nebraska, Map Series

KEITH COUNTY--LIST OF MAPS AND THEIR AUTHORS Topography--U. S. Geological Survey Index of 7.5\u27 Topographic Quadrangles and Township Boundaries--R. F. Diffendal, Jr. Generalized Soils Map--M. Kuzila and J. Culver Approximate Loess Thickness--R. F. Diffendal, Jr. Bedrock Geologic Map--R. F. Diffendal, Jr. Volcanic Ash Localities--R. F. Diffendal, Jr. Ogallala Vertebrate Faunal Sites--R. F. Diffendal, Jr. Ogallala Group Outcrops--R. F. Diffendal, Jr. White River Group Outcrops--R. F. Diffendal, Jr. Conservation and Survey Division Test Hole Locations--R. F. Diffendal, Jr. Oil and/or Gas Test Hole Locations--R. F. Diffendal, Jr. Mineral Resources Localities--R. F. Diffendal, Jr. Locations of Registered Irrigation Wells--R. F. Diffendal, Jr. Configuration of Top of Bedrock--R. F. Diffendal, Jr. Configuration of Top of White River Group (= Brule Fm.)--R. F. Diffendal, Jr. Configuration of Top of Cretaceous--H. M. DeGraw Configuration of Top of Niobrara Fm.--H. M. DeGraw Configuration of Base of Greenhorn Limestone--H. M. DeGraw Configuration of Top of Permian System--R. R. Burchett Structural Contours on Top of Stone Corral--R. R. Burchett Structural Contours on Top of Pennsylvanian System--R. R. Burchett Depth to Precambrian Surface--M. P. Carlson Configuration of Top of Precambrian--R. R. Burchett and M. P. Carlson Geothermal Projected Temperatures on Top of Dakota Group--D. Eversoll and W. Gosnold Bouguer Gravity Anomaly Map--R. R. Burchett and T. Eversol

A phenomenological exploration of exercise mental toughness: perceptions of exercise leaders and regular exercisers

Although elite sport has provided an ideal context for exploring mental toughness (MT), currently, there is scant research examining how this construct might be equally applicable in exercise settings, where high rates of attrition have been reported. The present research, therefore, aimed to address this gap, and to understand and conceptualise exercise mental toughness (EMT) through in-depth phenomenological interviews with a range of exercise leaders and exercise participants. Seven qualified and experienced exercise leaders and seven regular and frequent exercisers from formal exercise environments (i.e. gym and fitness classes) were interviewed. Interviews were digitally recorded, transcribed verbatim and analysed independently by members of the interdisciplinary research team. Key themes were agreed and member checking was used to promote trustworthiness of interpretations. MT was recognisable in exercise settings, with 10 general dimensions found to be relatively consistent with conceptualisations derived from elite sport (e.g. commitment, focus, emotional control, etc.). Importantly, present findings reveal how mentally tough exercisers think and behave in exercise settings. Some negative consequences were also reported such as over-training and training with injuries. The article also discusses how components of EMT may be valuable in terms of exercise maintenance and relapse prevention during exercise behaviour change

Nmnat1 protects neuronal function without altering phospho-tau pathology in a mouse model of tauopathy

OBJECTIVE: The nicotinamide‐nucleotide adenylyltransferase protein Nmnat1 is a potent inhibitor of axonal degeneration in models of acute axonal injury. Hyperphosphorylation and aggregation of the microtubule‐associated protein Tau are associated with neurodegeneration in Alzheimer's Disease and other disorders. Previous studies have demonstrated that other Nmnat isoforms can act both as axonoprotective agents and have protein chaperone function, exerting protective effects in drosophila and mouse models of tauopathy. Nmnat1 targeted to the cytoplasm (cytNmnat1) is neuroprotective in a mouse model of neonatal hypoxia‐ischemia, but the effect of cytNmnat1 on tauopathy remains unknown. METHODS: We examined the impact of overexpression of cytNmnat1 on tau pathology, neurodegeneration, and brain functional connectivity in the P301S mouse model of chronic tauopathy. RESULTS: Overexpression of cytNmnat1 preserved cortical neuron functional connectivity in P301S mice in vivo. However, whereas Nmnat1 overexpression decreased the accumulation of detergent‐insoluble tau aggregates in the cerebral cortex, it exerted no effect on immunohistochemical evidence of pathologic tau phosphorylation and misfolding, hippocampal atrophy, or inflammatory markers in P301S mice. INTERPRETATION: Our results demonstrate that cytNmnat1 partially preserves neuronal function and decreases biochemically insoluble tau in a mouse model of chronic tauopathy without preventing tau phosphorylation, formation of soluble aggregates, or tau‐induced inflammation and atrophy. Nmnat1 might thus represent a therapeutic target for tauopathies