7,245 research outputs found
Prolonging assembly through dissociation:A self assembly paradigm in microtubules
We study a one-dimensional model of microtubule assembly/disassembly in which
GTP bound to tubulins within the microtubule undergoes stochastic hydrolysis.
In contrast to models that only consider a cap of GTP-bound tubulin, stochastic
hydrolysis allows GTP-bound tubulin remnants to exist within the microtubule.
We find that these buried GTP remnants enable an alternative mechanism of
recovery from shrinkage, and enhances fluctuations of filament lengths. Under
conditions for which this alternative mechanism dominates, an increasing
depolymerization rate leads to a decrease in dissociation rate and thus a net
increase in assembly.Comment: accepted for publication in Physical Review
Who is in the transition gap? Transition from CAMHS to AMHS in the Republic of Ireland
Objective: The ITRACK study explored the process and predictors of transition between Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) in the Republic of Ireland. Method: Following ethical approval, clinicians in each of Ireland's four Health Service Executive (HSE) areas were contacted, informed about the study and invited to participate. Clinicians identified all cases who had reached the transition boundary (i.e. upper age limit for that CAMHS team ) between January and December 2010. Data were collected on clinical and socio-demographic details and factors that informed the decision to refer or not refer to AMHS and case notes were scrutinised to ascertain the extent of information exchanged between services during transition
The costs of single species programes and the budget constraint
Despite the scarcity of funding for species conservation programs, estimation of the cost of threatened species programs occurs in only a few countries. This paper examines the reasons for the lack of species program cost estimates and the likely impacts of this on conservation management. We report methodology used to estimate cost for eleven New Zealand species programs and their estimated costs over a ten year period. Differences between species in the costs of the programs and the breakdown of the costs are highlighted. The estimated costs are compared with expected levels of expenditure on each species to illustrate the existence of a budget constraint for threatened species. The likely effects of cost of species conservation exceeding expenditures on species conservation are examined. Annual cost data is used together with information on rate of conservation progress to estimate time and total cost for each species to reach âNot Threatenedâ status
Vascularization of the Selaginella rhizophore: anatomical fingerprints of polar auxin transport with implications for the deep fossil record
Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138403/1/nph14478_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138403/2/nph14478-sup-0005-Legends.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138403/3/nph14478.pd
Anti-Tumour Effect In Vitro of Lymphocytes and Macrophages from Mice Treated with Corynebacterium Parvum
Cells from the spleen, lymph node, peripheral blood and peritoneal exudate of mice treated with C. parvum were tested for their ability to inhibit tumour growth in vitro. The peritoneal exudate cells from C. parvum treated mice were extremely effective in inhibiting tumour growth whereas the spleen and peripheral blood cells were only moderately so. In contrast, the lymph node cells caused only a modest inhibition of tumour growth at a very high effector to target cell ratio. Spleen cells from normal mice also exerted a moderate anti-tumour effect
Schottky mass measurements of heavy neutron-rich nuclides in the element range 70\leZ \le79 at the ESR
Storage-ring mass spectrometry was applied to neutron-rich Au
projectile fragments. Masses of Lu, Hf, Ta,
W, and Re nuclei were measured for the first time. The
uncertainty of previously known masses of W and Os nuclei
was improved. Observed irregularities on the smooth two-neutron separation
energies for Hf and W isotopes are linked to the collectivity phenomena in the
corresponding nuclei.Comment: 10 pages, 9 figures, 2 table
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GAP WORK project report: training for youth practitioners on tackling gender-related violence
This project sought to challenge gender-related violence against (and by) children and young people by developing training for practitioners who have everyday contact with general populations of children and young people (âyouth practitionersâ). Through improved knowledge and understanding practitioners can better identify and challenge sexist, sexualising, homophobic or controlling language and behaviour, and know when and how to refer children and young people to the most appropriate support services. This summary outlines the Project and our initial findings about the success of the four training programmes developed and piloted.Co-funded by the DAPHNE III programme of the EU
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