Outcomes of cerebral venous thrombosis due to vaccine-induced immune thrombotic thrombocytopenia after the acute phase

© 2022 American Heart Association, Inc.Background: Cerebral venous thrombosis (CVT) due to vaccine-induced immune thrombotic thrombocytopenia (VITT) is a severe condition, with high in-hospital mortality rates. Here, we report clinical outcomes of patients with CVT-VITT after SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) vaccination who survived initial hospitalization. Methods: We used data from an international registry of patients who developed CVT within 28 days of SARS-CoV-2 vaccination, collected until February 10, 2022. VITT diagnosis was classified based on the Pavord criteria. Outcomes were mortality, functional independence (modified Rankin Scale score 0–2), VITT relapse, new thrombosis, and bleeding events (all after discharge from initial hospitalization). Results: Of 107 CVT-VITT cases, 43 (40%) died during initial hospitalization. Of the remaining 64 patients, follow-up data were available for 60 (94%) patients (37 definite VITT, 9 probable VITT, and 14 possible VITT). Median age was 40 years and 45/60 (75%) patients were women. Median follow-up time was 150 days (interquartile range, 94–194). Two patients died during follow-up (3% [95% CI, 1%–11%). Functional independence was achieved by 53/60 (88% [95% CI, 78%–94%]) patients. No new venous or arterial thrombotic events were reported. One patient developed a major bleeding during follow-up (fatal intracerebral bleed). Conclusions: In contrast to the high mortality of CVT-VITT in the acute phase, mortality among patients who survived the initial hospitalization was low, new thrombotic events did not occur, and bleeding events were rare. Approximately 9 out of 10 CVT-VITT patients who survived the acute phase were functionally independent at follow-up.This study was funded by the Netherlands Organisation for Health Research and Development (ZonMw, grant number 10430072110005), the Dr. C.J. Vaillant Foundation, and Hospital District of Helsinki and Uusimaa (grant TYH2022223).info:eu-repo/semantics/publishedVersio

Histological and molecular biology diagnosis of neurocysticercosis in a patient without history of travel to endemic areas - case report

EA MERS CT3 Enjeu 3Background: in endemic areas, neurocysticercosis appears mainly as a single, large, spherical and non-enhancing intracranial cyst. Case presentation: an atypical case of neurocysticercosis (NCC) in a French Caucasian, without history of travel to endemic areas, was confirmed by histology and molecular speciation. Imaging was atypical, showing several hook-bearing scolices visible in the cyst, while the serology employed was non-contributary. Conclusions: NCC should be considered when multiple taeniid scolices are observed within the same cystic lesion.Contexte : en zone endémique, les lésions kystiques intra-crâniales de neurocysticercose sont classiquement uniques, étendues, sphériques et sans prise de contraste. Cas clinique : un cas atypique de neurocysticercose (NCC) chez un caucasien français n’ayant jamais voyagé en zone d’endémie a été confirmé par histologie et biologie moléculaire. L’imagerie était atypique, montrant plusieurs scolex surmontés de crochets et localisés au sein d’une même lésion kystique. La sérologie était non contributive pour le diagnostic. Conclusions : le diagnostic de NCC doit être évoqué lorsque plusieurs scolex sont observés au sein d’une même lésion kystique

Histological and molecular biology diagnosis of neurocysticercosis in a patient without history of travel to endemic areas – Case report

Background: in endemic areas, neurocysticercosis appears mainly as a single, large, spherical and non-enhancing intracranial cyst. Case presentation: an atypical case of neurocysticercosis (NCC) in a French Caucasian, without history of travel to endemic areas, was confirmed by histology and molecular speciation. Imaging was atypical, showing several hook-bearing scolices visible in the cyst, while the serology employed was non-contributary. Conclusions: NCC should be considered when multiple taeniid scolices are observed within the same cystic lesion

Hydro-contamination fongique par Fusarium spp. en milieu hospitalier pendant une période de construction

National audienc

Dynamique de la colonisation fongique dans un nouveau laboratoire de mycologie médicale

International audienceObjective of the study. - Study of the spatio-temporal fungal colonization in a new medical mycology laboratory. Methods. - A 17-month survey of airborne fungal contamination was conducted in a new medical mycology laboratory at a tertiary care university hospital. This survey was implemented at three different periods: before the new premises were occupied (period A), during the move into the new laboratory (period B) and after resumption of the mycological activities in these new premises (period C). Results. - During period A, the airborne fungal load ranged from 2.3 to 6 cfu/m(3). The most frequently recovered airborne fungi were Penicillium spp. (75 to 100%). During period B, a dramatic increase in Penicillium chrysogenum conidia was observed in the air of the new laboratory (40 to 160 cfu/m(3)). During period C, the fungal load ranged from 4.5 to 8.4 cfu/m(3). Penicillium was the most common genus identified in rooms of the laboratory where no filamentous fungi were handled, while Aspergillus was clearly the predominant genus (78%) in the room dedicated to the culture of filamentous fungi. Conclusions. - We suggest that the specific fungal ecology in air of the room dedicated to the culture of filamentous fungi is due to the handling of a large number of medical strains of A. fumigatus.Objectif de l’étude : Étude spatio-temporelle de la colonisation fongique dans un nouveau laboratoire de mycologie médicale. Méthodes : Durant 17 mois, l’aérocontamination fongique a été évaluée dans trois pièces d’un nouveau laboratoire de mycologie médicale d’un centre hospitalo-universitaire. Cette surveillance a été programmée à trois périodes différentes : avant l’occupation des nouveaux locaux (période A), durant l’emménagement dans le nouveau laboratoire (période B) et après la reprise des activités de mycologie médicale dans ces nouveaux locaux (période C). Résultats : Durant la période A, la charge fongique dans l’air était comprise entre 2,3 et 6 ufc/m3. Le micromycète le plus fréquemment isolé a été Penicillium spp. (75 à 100 %). Durant la période B, une très forte augmentation de la charge en conidies de Penicillium chrysogenum a été observée dans l’air du nouveau laboratoire (40 à 160 ufc/m3). Durant la période C, la charge fongique a été comprise entre 4,5 et 8,4 ufc/m3. Penicillium a été le genre le plus fréquemment identifié dans les deux pièces du laboratoire où aucun champignon filamenteux n’est manipulé, alors qu’Aspergillus a clairement été le genre prédominant (78 %) dans la pièce consacrée à la culture des champignons filamenteux. Conclusions : Nous suggérons que la manipulation d’un grand nombre de souches médicales d’Aspergillus est à l’origine de l’écologie spécifique qui existe dans la pièce du laboratoire destinée à la manipulation des champignons filamenteux