Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Latin American study of hereditary breast and ovarian cancer LACAM : a genomic epidemiology approach

Q2Q1Artículo original1-13Purpose: Hereditary Breast and Ovarian Cancer (HBOC) syndrome is responsible for ~5–10% of all diagnosed breast and ovarian cancers. Breast cancer is the most common malignancy and the leading cause of cancer-related mortality among women in Latin America (LA). The main objective of this study was to develop a comprehensive understanding of the genomic epidemiology of HBOC throughout the establishment of The Latin American consortium for HBOC-LACAM, consisting of specialists from 5 countries in LA and the description of the genomic results from the first phase of the study. Methods: We have recruited 403 individuals that fulfilled the criteria for HBOC from 11 health institutions of Argentina, Colombia, Guatemala, Mexico and Peru. A pilot cohort of 222 individuals was analyzed by NGS gene panels. One hundred forty-three genes were selected on the basis of their putative role in susceptibility to different hereditary cancers. Libraries were sequenced in MiSeq (Illumina, Inc.) and PGM (Ion Torrent-Thermo Fisher Scientific) platforms. Results: The overall prevalence of pathogenic variants was 17% (38/222); the distribution spanned 14 genes and varied by country. The highest relative prevalence of pathogenic variants was found in patients from Argentina (25%, 14/57), followed by Mexico (18%, 12/68), Guatemala (16%, 3/19), and Colombia (13%, 10/78). Pathogenic variants were found in BRCA1 (20%) and BRCA2 (29%) genes. Pathogenic variants were found in other 12 genes, including high and moderate risk genes such as MSH2, MSH6, MUTYH, and PALB2. Additional pathogenic variants were found in HBOC unrelated genes such as DCLRE1C, WRN, PDE11A, and PDGFB. Conclusion: In this first phase of the project, we recruited 403 individuals and evaluated the germline genetic alterations in an initial cohort of 222 patients among 4 countries. Our data show for the first time in LA the distribution of pathogenic variants in a broad set of cancer susceptibility genes in HBOC. Even though we used extended gene panels, there was still a high proportion of patients without any detectable pathogenic variant, which emphasizes the larger, unexplored genetic nature of the disease in these populations

Autoestima y rendimiento académico en estudiantes de enfermería de Poza Rica, Veracruz, México

El artículo se origina de los resultados de investigación obtenidos con el proyecto «Autoestima y rendimiento académico», cuyo objetivo general fue determinar la relación que existe entre ambas variables en estudiantes de la Facultad de Enfermería de Poza Rica de la Universidad Veracruzana.Fue un estudio correlacional con valor explicativo. La autoestima fue valorada con la aplicación del Inventario de Autoestima de Coopersmith. En cuanto al rendimiento académico, se obtuvieron los promedios ponderados semestrales a través del kardex. Hay resultados que podemos destacar: el 19% de los estudiantes tiene autoestima alta, de los cuales el 16% obtiene un rendimiento académico entre bueno y excelente, y el 3%, entre regular y bajo. Lo cual permite inferir, con Rogers (2000) la importancia del concepto de sí mismo y de autoestima positiva en los procesos cognitivos y afectivos de los estudiantes. De ahí la necesidad de incrementaren el universitario su nivel de autoestima

Hábitos de estudio y rendimiento académico en enfermería, Poza Rica, Veracruz, México / Study habits and academic performance in nursing, Poza Rica, Veracruz Mexico

El objetivo de la investigación fue determinar la relación que existe entre los hábitos de estudio y el rendimiento académico en los estudiantes de la Facultad de Enfermería Poza Rica-Tuxpan, a fin de proponer alternativas que permitan el incremento del rendimiento académico y personal del estudiante. El tipo y diseño de investigación fue descriptivo y correlacional. La población se constituyo por 397 estudiantes inscritos en el periodo febrero-agosto 2010. El tipo de muestreo fue probabilístico estratificado, 79 estudiantes conformaron la muestra, se aplicó el inventario de hábitos de estudio de Gilbert Wrenn y el rendimiento académico se considero como el promedio que obtuvieron en el semestre anterior. Como resultados se obtuvo que el 85% de estudiantes posean hábitos de estudio regulares y en el 15% son deficientes. Respecto al rendimiento académico en el 23% es excelente, en el 62% es de bueno a regular y solo en el 15% su promedio es bajo.Al correlacionar los hábitos de estudio con el rendimiento académico se observa correlación significativa entre ellos, por tanto se acepta la hipótesis de investigación correlacional y se rechaza la hipótesis nula. Estos resultados llevan a la reflexión de diseñar una estrategia metodológica para trabajar los hábitos de estudio desde el ingreso del estudiante a la universidad en aras de mejorar el rendimiento académico.   The research objective was to determine the relationship between study habits and academic performance among students in the School of Nursing Poza Rica-Tuxpan, to propose alternatives to the increased academic performance and student staff. The type and design was descriptive and correlational research. The population consisted of 397 students enrolled in the period February to August 2010. The sampling was stratified probability, 79 students formed the sample was applied to the inventory of Gilbert's study habits and academic performance Wrenn was considered as the average obtained in the previous semester. The result was that 85% of students hold regular study habits and 15% are poor. With regard to academic performance in 23% excellent, 62% are regular and good, and only in 15% of his average is low. By correlating the habits of academic study with significant correlation was seen between them, so accepts the correlational research hypotheses and rejecting the null hypothesis. These results lead to the thought of designing a methodological strategy to work the study habits of students from admission to college in order to improve academic performance

Hábitos de estudio y rendimiento académico en enfermería, Poza Rica, Veracruz, México / Study habits and academic performance in nursing, Poza Rica, Veracruz Mexico

El objetivo de la investigación fue determinar la relación que existe entre los hábitos de estudio y el rendimiento académico en los estudiantes de la Facultad de Enfermería Poza Rica-Tuxpan, a fin de proponer alternativas que permitan el incremento del rendimiento académico y personal del estudiante. El tipo y diseño de investigación fue descriptivo y correlacional. La población se constituyo por 397 estudiantes inscritos en el periodo febrero-agosto 2010. El tipo de muestreo fue probabilístico estratificado, 79 estudiantes conformaron la muestra, se aplicó el inventario de hábitos de estudio de Gilbert Wrenn y el rendimiento académico se considero como el promedio que obtuvieron en el semestre anterior. Como resultados se obtuvo que el 85% de estudiantes posean hábitos de estudio regulares y en el 15% son deficientes. Respecto al rendimiento académico en el 23% es excelente, en el 62% es de bueno a regular y solo en el 15% su promedio es bajo.Al correlacionar los hábitos de estudio con el rendimiento académico se observa correlación significativa entre ellos, por tanto se acepta la hipótesis de investigación correlacional y se rechaza la hipótesis nula. Estos resultados llevan a la reflexión de diseñar una estrategia metodológica para trabajar los hábitos de estudio desde el ingreso del estudiante a la universidad en aras de mejorar el rendimiento académico. The research objective was to determine the relationship between study habits and academic performance among students in the School of Nursing Poza Rica-Tuxpan, to propose alternatives to the increased academic performance and student staff. The type and design was descriptive and correlational research. The population consisted of 397 students enrolled in the period February to August 2010. The sampling was stratified probability, 79 students formed the sample was applied to the inventory of Gilbert's study habits and academic performance Wrenn was considered as the average obtained in the previous semester. The result was that 85% of students hold regular study habits and 15% are poor. With regard to academic performance in 23% excellent, 62% are regular and good, and only in 15% of his average is low. By correlating the habits of academic study with significant correlation was seen between them, so accepts the correlational research hypotheses and rejecting the null hypothesis. These results lead to the thought of designing a methodological strategy to work the study habits of students from admission to college in order to improve academic performance

Growth, nutrient uptake and proximate composition of Rhodomonas sp. cultured using f/2 medium and agricultural fertilizers

We determined the growth, nutrient (PO43–, NO3–, NH4+) uptake and proximate composition of Rhodomonas sp. cultured during seven days in batch culture using f/2 medium and agricultural fertilizers. The growth rate was similar with both media (µ = 0.37 and 0.38 day–1). Protein content in Rhodomonas sp. cultured with f/2 medium was higher than with agricultural fertilizers (10.7 and 8.96 pg cell–1, respectively). Carbohydrate and lipid contents decreased during the exponential growth phase and there were no significant differences (P = 0.027 and 0.08, respectively) between both experiments. Carbohydrate content was higher during the slow growth phase in cultures using f/2 medium, whereas lipid content showed little variation during the slow growth phase, but was higher in cells cultured using agricultural fertilizers. During the first five days, total phosphate uptake by Rhodomonas sp. was 39.9 µM (94.3%) in the f/2 medium and 40 µM (99%) in the agricultural fertilizer medium. A total of 667.3 µM of nitrate (72.2%) was consumed during the first four days in the f/2 medium, whereas in the agricultural fertilizer medium formulated with ammonium nitrate, ammonium uptake (418.1 µM, 78.7%) in the first three days was higher than nitrate uptake (37.7 µM, 7.3%); however, when ammonium concentration decreased to 1.83 µM, the nitrate uptake increased. In conclusion, the cellular quantity and quality of Rhodomonas sp. was similar when both media were used and agricultural fertilizers can be used in marine aquaculture programs

Propuesta de implantación de un sistema informático de planificación de recursos (ERP), en la empresa Dispositivos Médicos Premium, S.A. de C.V.

Seminario: Estrategias comunicativas para la mejora continua, en las organizacione

Proyectos de inversión, su financiamiento y análisis

Conductor : Amapola Pando De Lir

Estrategias de Comunicación - HE60 - 202102

Descripción: Estrategias de Comunicación es un curso de Humanidades, que brinda al participante un conjunto de herramientas lingüísticas para la redacción de textos en el entorno académico, tales como el uso apropiado de la normativa del español y la aplicación de estrategias explicativas. En el curso, el estudiante redacta párrafos de desarrollo y textos con estructura IDC. Propósito: El curso desarrolla la competencia de comunicación escrita en el primer nivel de logro. Tiene como prerrequisito el curso de Estrategias de Redacción. La asignatura se orienta a la redacción de textos formales que ayuden a optimizar el desempeño profesional del participante en el entorno universitario