Evidence that the radioprotector effect of ascorbic acid depends on the radiation dose rate.

En este artículo se da a conocer que los daños ocasionados por el ácido ascórbico dependen de la dosis expuesta.Many studies have revealed that ascorbic acid (Aa) acts as a powerful inhibitor of genetic damage. The objetive of the present study was to evaluate the radioprotector effect of Aa at two diferent radiation dose rates. The somatic mutation and recombination test in Drosophilamelanogaster was used. 48 h larvae were treated for 24 h with 25, 50 and 100 mM of Aa. After pretreatment, larvae were irradiated with 20 Gy of gamma rays administered at 36 or 960 Gy/h. Toxicity, development rate and frequency of mutant spots were recorded. Results provide evidence of a radioprotective effect for all tested concentrations of Aa only when 20 Gy were delivered at 36 Gy/h and only with 25 mM using the 960 Gy/h. To consider the use of Aa as radioprotector or therapeutic agent, it is necessary to know its potential under different situations to avoid unwanted injuries.CONACy

Insecticide activity of bifenthrin nanoparticles synthesized by laser ablation of solids in liquids

ARTICULO DE INVESTIGACIONARTICULO DE INVESTIGACIO

Analysis and Design of the Knowledge Representation for the Implementation of a Distributed Reasoning

The representation of knowledge and the reasoning comprise fundamental parts of the design of an expert system. In the case under study the real world is represented by the different events that can arise in the operation of a nuclear plant. These events are characterized by a set of elements interrelated through expert reasoning. We have chosen fuzzy cognitive maps (FCM) for the representation of the expert reasoning front to a fault event, because it handles the uncertainty in the decision making, through the interrelation among its elements. In addition, the FCM emphasizes a representation that allows parallel distributed reasoning (PDR). In our work we detail the analysis and design that was developed to build the causality matrices that give origin to the distributed reasoning, and ultimately have a representation in the FCMs.La representación del conocimiento y el razonamiento forma parte fundamental del diseño del sistema experto. En el caso de estudio, el mundo real está representado porlos distintos eventos que se pueden manifestar en la operación de la planta nuclear. Dichos eventos se caracterizan por un conjunto de elementos interrelacionados a través del razonamiento experto. Hemos elegido los mapas cognoscitivos difusos (MCD) para la representación del razonamiento experto frente a un evento de falla, debido a que  éstos, logran manejar la incertidumbre en la toma de decisiones, a través de la interrelación de sus elementos, además de potenciar el razonamiento distribuido paralelo (RPD). En este trabajo se detalla el análisis y diseño de las matrices causales que dan origen al razonamiento distribuido, y que finalmente tienen una representación en los MCD

Executive Summary of the Second International Guidelines for the Diagnosis and Management of Pediatric Acute Respiratory Distress Syndrome (PALICC-2)

OBJECTIVES: We sought to update our 2015 work in the Second Pediatric Acute Lung Injury Consensus Conference (PALICC-2) guidelines for the diagnosis and management of pediatric acute respiratory distress syndrome (PARDS), considering new evidence and topic areas that were not previously addressed. DESIGN: International consensus conference series involving 52 multidisciplinary international content experts in PARDS and four methodology experts from 15 countries, using consensus conference methodology, and implementation science. SETTING: Not applicable. PATIENTS: Patients with or at risk for PARDS. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Eleven subgroups conducted systematic or scoping reviews addressing 11 topic areas: 1) definition, incidence, and epidemiology; 2) pathobiology, severity, and risk stratification; 3) ventilatory support; 4) pulmonary-specific ancillary treatment; 5) nonpulmonary treatment; 6) monitoring; 7) noninvasive respiratory support; 8) extracorporeal support; 9) morbidity and long-term outcomes; 10) clinical informatics and data science; and 11) resource-limited settings. The search included MEDLINE, EMBASE, and CINAHL Complete (EBSCOhost) and was updated in March 2022. Grading of Recommendations, Assessment, Development, and Evaluation methodology was used to summarize evidence and develop the recommendations, which were discussed and voted on by all PALICC-2 experts. There were 146 recommendations and statements, including: 34 recommendations for clinical practice; 112 consensus-based statements with 18 on PARDS definition, 55 on good practice, seven on policy, and 32 on research. All recommendations and statements had agreement greater than 80%. CONCLUSIONS: PALICC-2 recommendations and consensus-based statements should facilitate the implementation and adherence to the best clinical practice in patients with PARDS. These results will also inform the development of future programs of research that are crucially needed to provide stronger evidence to guide the pediatric critical care teams managing these patients.</p

A Further Study of the Role of Copper in Regard to the Antimutagenic Action of Sodium Copper Chlorophyllin (SCC) in Somatic Cells of

Previous findings suggest that copper plays a crucial role in the antimutagenic effect of sodium copper chlorophyllin (SCC). The objective of the current research was to compare the antimutagenic effects of two SCC compounds with different amounts of copper (3.7% and 5.4%, respectively) on the genetic damage induced by gamma rays in somatic cells of Drosophila . Data indicate that an increase in copper content of 31.5% in SCC-5.4 resulted in a greater inhibition of gamma ray genetic damage of 49% whereas only a 2% inhibition with SCC-3.7 occurred. Of greater interest is the association of SCC with a variety of uses in humans, such as a chemo preventive agent and food supplement. A greater attention to the concentration of copper in the SCC product in use should be required

Analysis and Design of the Knowledge Representation for the Implementation of a Distributed Reasoning

The representation of knowledge and the reasoning comprise fundamental parts of the design of an expert system. In the case under study the real world is represented by the different events that can arise in the operation of a nuclear plant. These events are characterized by a set of elements interrelated through expert reasoning. We have chosen fuzzy cognitive maps (FCM) for the representation of the expert reasoning front to a fault event, because it handles the uncertainty in the decision making, through the interrelation among its elements. In addition, the FCM emphasizes a representation that allows parallel distributed reasoning (PDR). In our work we detail the analysis and design that was developed to build the causality matrices that give origin to the distributed reasoning, and ultimately have a representation in the FCMs.La representación del conocimiento y el razonamiento forma parte fundamental del diseño del sistema experto. En el caso de estudio, el mundo real está representado porlos distintos eventos que se pueden manifestar en la operación de la planta nuclear. Dichos eventos se caracterizan por un conjunto de elementos interrelacionados a través del razonamiento experto. Hemos elegido los mapas cognoscitivos difusos (MCD) para la representación del razonamiento experto frente a un evento de falla, debido a que  éstos, logran manejar la incertidumbre en la toma de decisiones, a través de la interrelación de sus elementos, además de potenciar el razonamiento distribuido paralelo (RPD). En este trabajo se detalla el análisis y diseño de las matrices causales que dan origen al razonamiento distribuido, y que finalmente tienen una representación en los MCD

Un diseño de interfaz: tomando en cuenta los estilos de aprendizaje

La percepción del color, por los individuos, y sus repercusiones a niveles sensorial y psicológico, son indiscutibles; los colores son capaces de provocar o modificar estados de ánimo y esto lo saben bien tanto arquitectos, decoradores, publicistas, diseñadores y demás creativos que, de acuerdo a los atributos únicos de cada color logran impactar a los espectadores o usuarios, al crear sensaciones y ambientes, vestir productos, etc. ¿Porqué no usar esta característica para potencializar el proceso de aprendizaje? En este artículo se presenta una propuesta de combinaciones de colores para cada uno de los tipos de aprendizaje tomando en cuenta el tipo de inteligencia predominante en el usuario, aplicados todos ellos a un Sistema de Aprendizaje Inteligente. Estos elementos constituyen una de los tres componentes básicos para crear una interfaz