16 research outputs found
Coleta transcervical de embriões em ovinos da raça Dorper no semiárido do nordeste brasileiro
Influência do estrógeno e do interferon γ sobre a expressão da indoleamina-2,3-dioxigenase em cultura de células de placenta e embriões de ratas Wistar
Identification Of The Primary Outcomes That Result From Deficient Spiral Arterial Modification In Pregnant Mice
Pre-eclampsia, an acute complication of human pregnancy, is associated with incomplete physiological modification of decidual spiral arteries. This is thought to promote oxidative stress from perfusion/reperfusion of the placenta and to restrict placental and fetal growth. Alymphoid (genotype Rag2 -/-/Il2rg-/-) mice, sufficient in dendritic and myeloid cell functions, lack spiral arterial modification with individual spiral arteries having ∼1.7× the vascular resistance and 0.66× the blood velocity of +/+ mice. Their placentae are not measurably hypoxic and neither placental growth nor fetal survival is impaired and gestational hypertension is not seen. Thus, lymphocytes rather than vascular adaptations appear to be the pivotal contributors to the clinical complications of pre-eclampsia. © 2010 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved.118794Redman, C.W., Sargent, I.L., Latest advances in understanding preeclampsia (2005) Science, 308, pp. 1592-1594Lyall, F., Belfort, M., (2007) Pre-eclampsia. Etiology and Clinical Practice, , Cambridge University Press Cambridge, UKPijnenborg, R., Dixon, G., Robertson, W.B., Brosens, I., Trophoblastic invasion of human decidua from 8 to 18 weeks of pregnancy (1980) Placenta, 1, pp. 3-19Pijnenborg, R., Vercruysse, L., Hanssens, M., The uterine spiral arteries in human pregnancy: Facts and controversies (2006) Placenta, 27, pp. 939-958Redline, R.W., Patterson, P., Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast (1995) Hum Pathol, 26, pp. 594-600Kaufmann, P., Black, S., Huppertz, B., Endovascular trophoblast invasion: Implications for the pathogenesis of intrauterine growth retardation and preeclampsia (2003) Biol Reprod, 69, pp. 1-7Levine, R.J., Maynard, S.E., Qian, C., Circulating angiogenic factors and the risk of preeclampsia (2004) N Engl J Med, 350, pp. 672-683Romero, R., Nien, J.K., Espinoza, J., A longitudinal study of angiogenic (placental growth factor) and anti-angiogenic (soluble endoglin and soluble vascular endothelial growth factor receptor-1) factors in normal pregnancy and patients destined to develop preeclampsia and deliver a small for gestational age neonate (2008) J Matern Fetal Neonatal Med, 21, pp. 9-23Maynard, S., Epstein, F.H., Karumanchi, S.A., Preeclampsia and angiogenic imbalance (2008) Annu Rev Med, 59, pp. 61-78Herse, F., Verlohren, S., Wenzel, K., Prevalence of agonistic autoantibodies against the angiotensin II type 1 receptor and soluble fms-like tyrosine kinase 1 in a gestational age-matched case study (2009) Hypertension, 53, pp. 393-398Herse, F., Staff, A.C., Hering, L., AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia (2008) J Mol Med, 86, pp. 697-703Hiby, S.E., Walker, J.J., O'Shaughnessy, K.M., Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success (2004) J Exp Med, 200, pp. 957-965Founds, S.A., Conley, Y.P., Lyons-Weiler, J.F., Altered global gene expression in first trimester placentas of women destined to develop preeclampsia (2009) Placenta, 30, pp. 15-24Peel, S., Granulated metrial gland cells (1989) Adv Anat Embryol Cell Biol, 115, pp. 1-112Wang, B., Biron, C., She, J., A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene (1994) Proc Natl Acad Sci USA, 91, pp. 9402-9406Disanto, J.P., Muller, W., Guy-Grand, D., Fischer, A., Rajewsky, K., Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain (1995) Proc Natl Acad Sci USA, 92, pp. 377-381Guimond, M.J., Wang, B., Fujita, J., Terhorst, C., Croy, B.A., Pregnancy-associated uterine granulated metrial gland cells in mutant and transgenic mice (1996) Am J Reprod Immunol, 35, pp. 501-509Greenwood, J.D., Minhas, K., Di Santo, J.P., Ultrastructural studies of implantation sites from mice deficient in uterine natural killer cells (2000) Placenta, 21, pp. 693-702Guimond, M.J., Wang, B., Croy, B.A., Engraftment of bone marrow from severe combined immunodeficient (SCID) mice reverses the reproductive deficits in natural killer cell-deficient tg epsilon 26 mice (1998) J Exp Med, 187, pp. 217-223Ashkar, A.A., Di Santo, J.P., Croy, B.A., Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy (2000) J Exp Med, 192, pp. 259-270Murphy, S.P., Tayade, C., Ashkar, A.A., Interferon gamma in successful pregnancies (2009) Biol Reprod, 80, pp. 848-859Germain, S.J., Sacks, G.P., Sooranna, S.R., Sargent, I.L., Redman, C.W., Systemic inflammatory priming in normal pregnancy and preeclampsia: The role of circulating syncytiotrophoblast microparticles (2007) J Immunol, 178, pp. 5949-5956Redman, C.W., Sargent, I.L., Microparticles and immunomodulation in pregnancy and pre-eclampsia (2007) J Reprod Immunol, 76, pp. 61-67Gammill, H.S., Roberts, J.M., Emerging concepts in preeclampsia investigation (2007) Front Biosci, 12, pp. 2403-2411Bainbridge, S.A., Roberts, J.M., Von Versen-Hoynck, F., Uric acid attenuates trophoblast invasion and integration into endothelial cell monolayers (2009) Am J Physiol Cell Physiol, 297, pp. 440-C450Hershkovitz, R., De Swiet, M., Kingdom, J., Mid-trimester placentation assessment in high-risk pregnancies using maternal serum screening and uterine artery Doppler (2005) Hypertens Pregnancy, 24, pp. 273-280Burton, G.J., Jauniaux, E., Placental oxidative stress: From miscarriage to preeclampsia (2004) J Soc Gynecol Invest, 11, pp. 342-352Thachil, J., Toh, C.H., Disseminated intravascular coagulation in obstetric disorders and its acute haematological management (2009) Blood Rev, 23, pp. 167-176Roberts, J.M., Gammill, H., Pre-eclampsia and cardiovascular disease in later life (2005) Lancet, 366, pp. 961-962Smith, G.N., Walker, M.C., Liu, A., A history of preeclampsia identifies women who have underlying cardiovascular risk factors (2009) Am J Obstet Gynecol, 200Burke, S.D., Barrette, V.F., Bianco, J., Spiral arterial remodeling is not essential for normal blood pressure regulation in pregnant mice (2010) Hypertension, 55Mu, J., Slevin, J.C., Qu, D., McCormick, S., Adamson, S.L., In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound (2008) Reprod Biol Endocrinol, 6, p. 34Zhang, J., Croy, B.A., Using ultrasonography to define fetal-maternal relationships: Moving from humans to mice (2009) Comp Med, 59, pp. 527-533Pal, S., Peterson, E.M., De La Maza, L.M., A murine model for the study of Chlamydia trachomatis genital infections during pregnancy (1999) Infect Immun, 67, pp. 2607-2610Buzas, E.I., Hollo, K., Rubliczky, L., Effect of pregnancy on proteoglycan-induced progressive polyarthritis in BALB/c mice: Remission of disease activity (1993) Clin Exp Immunol, 94, pp. 252-260Zhang, J., Dong, H., Wang, B., Zhu, S., Croy, B.A., Dynamic changes occur in patterns of endometrial EFNB2/EPHB4 expression during the period of spiral arterial modification in mice (2008) Biol Reprod, 79, pp. 450-458Guzik, T.J., Hoch, N.E., Brown, K.A., Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction (2007) J Exp Med, 204, pp. 2449-2460Hoch, N.E., Guzik, T.J., Chen, W., Regulation of T-cell function by endogenously produced angiotensin II (2009) Am J Physiol Regul Integr Comp Physiol, 296, pp. 208-R216Jurewicz, M., McDermott, D.H., Sechler, J.M., Human T and natural killer cells possess a functional renin-angiotensin system: Further mechanisms of angiotensin II-induced inflammation (2007) J Am Soc Nephrol, 18, pp. 1093-1102Madhur, M.S., Lob, H.E., McCann, L.A., Interleukin 17 promotes angiotensin II-induced hypertension, vascular dysfunction (2009) HypertensionHatta, K., Carter, A.L., Chen, Z., Leno-Durán, E., Ruiz-Ruiz, C., Olivares, E.G., Tse, M.Y., Croy, B.A., Dynamic expression of the vasoactive proteins Agtr1, Agtr2 and Nppa by mouse uterine Natural Killer cells Reprod Sci, , [Epub Oct.19]Guimond, M., Wang, B., Croy, B.A., Immune competence involving the natural killer cell lineage promotes placental growth (1999) Placenta, 20, pp. 441-450Paffaro Jr., V.A., Bizinotto, M.C., Joazeiro, P.P., Yamada, A.T., Subset classification of mouse uterine natural killer cells by DBA lectin reactivity (2003) Placenta, 24, pp. 479-48
NK Cells Detect Changes in Adaptive Immunity within Mouse Decidua from Gestation Day Eight
Update On Pathways Regulating The Activation Of Uterine Natural Killer Cells, Their Interactions With Decidual Spiral Arteries And Homing Of Their Precursors To The Uterus
Virgin adult C57Bl/6J mouse uterus contains a population of small, non-granulated Natural Killer (NK) cells with balanced expression of NK cell activating and inhibiting LY49 receptors. Coincident with blastocyst implantation and decidualization, uterine (u)NK cells become activated. The surface glycoslyation of uNK changes, the cells proliferate and they induce production of interferon (IFN)γ, perforin, serine esterases and other molecules, including angiogenic factors. Mouse strains genetically ablated in uNK cells fail to undergo modification of spiral artery segments that branch from the uterine artery and feed into the placenta and these mice do not sustain a robust decidualization response. IFN-γ is thought, from bone marrow transplantation and therapeutic studies, to be the key uNK-cell derived mediator regulating gene expression in vascular and decidual tissues. Here, we review recent studies showing that IL-15 is the critical cytokine controlling uNK cell differentiation and that uNK cells are activated by either IL-12 or IL-18 and by other factors when both IL-12 and IL-18 are genetically absent from implantation sites. We address possible roles of the IFN-γ regulated gene α2-macroglobulin (α2-M) in regulation of the position of fetal trophoblast within the walls of the spiral arteries, and we discuss approaches that have been successful in evaluating mechanisms involved in homing of mouse uNK cell precursors to the uterus. These approaches maybe applicable to studies in women. Our studies show that complex immuno-physiological events contribute to spiral artery modification by mid-gestation in mice. © 2003 Elsevier Science Ireland Ltd. All rights reserved.592175191Anderson, S.K., Ortaldo, J.R., McVicar, D.W., The ever-expanding Ly49 gene family: Repertoire and signaling (2001) Immunol. Rev., 181, pp. 79-89Ashkar, A.A., (2000) Functions of uterine natural killer cell-derived interferon gamma in the pregnant mouse uterus, , Ph.D. thesis, University of GuelphAshkar, A.A., Croy, B.A., Interferon-gamma contributes to the normalcy of murine pregnancy (1999) Biol. Reprod., 61, pp. 493-502Ashkar, A.A., Di Santo, J.P., Croy, B.A., Interferon gamma contributes to initiation of uterine vascular modification, decidual integrity, and uterine natural killer cell maturation during normal murine pregnancy (2000) J. Exp. Med., 192, pp. 259-270Blery, M., Olcese, L., Vivier, E., Early signaling via inhibitory and activating NK receptors (2000) Hum. Immunol., 61, pp. 51-64Boehm, U., Guethlein, L., Klamp, T., Ozbek, K., Schaub, A., Futterer, A., Pfeffer, K., Howard, J.C., Two families of GTPases dominate the complex cellular response to IFN-gamma (1998) J. Immunol., 161, pp. 6715-6723Briard, D., Brouty-Boye, D., Azzarone, B., Jasmin, C., Fibroblasts from human spleen regulate NK cell differentiation from blood CD34(+) progenitors via cell surface IL-15 (2002) J. Immunol., 168, pp. 4326-4332Campbell, K.S., Colonna, M., Human natural killer cell receptors and signal transduction (2001) Int. Rev. Immunol., 20, pp. 333-370Chantakru, S., (1998) Assessment of uterus and spleen as sources of uterine natural killer cell precursors in murine pregnancy, , M.Sc. thesis, University of GuelphChantakru, W., Miller, C., Roach, L.E., Kuziel, W.A., Maeda, N., Wang, W.C., Evans, S.S., Croy, B.A., Contributions from self-renewal and trafficking to the uterine NK cell population of early pregnancy (2002) J. Immunol., 168, pp. 22-28Chantakru, S., Wang, W.-C., Croy, B.A., Evans, S.S., (2003) Coordinate regulation of lymphocyte-endothelial interactions by pregnancy-associated hormones, , Submitted for publicationChaouat, G., Zourbas, S., Ostojic, S., Lappree-Delage, G., Dubanchet, S., Ledee, N., Martal, J., A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy (2002) J. Reprod. Immunol., 53, pp. 241-256Chen, Q., Ghilardi, N., Wang, H., Baker, T., Xie, M.H., Gurney, A., Grewal, I.S., De Sauvage, F.J., Development of Th1-type immune responses requires the type I cytokine receptor TCCR (2000) Nature, 407, pp. 916-920Colucci, F., Di Santo, J.P., Liebson, P.J., Natural killer cell activation in mice and men: Different triggers for similar weapons (2002) Nat. Immunol., 3, pp. 807-813Croy, B.A., Ashkar, A.A., Foster, R.A., DiSanto, J.P., Magram, J., Carson, D., Gendler, S.J., Guimond, M.J., Histological studies of gene-ablated mice support important functional roles for natural killer cells in the uterus during pregnancy (1997) J. Reprod. Immunol., 35, pp. 111-133Croy, B.A., Black, G.P., Ashkar, A.A., Analysis of the roles of interleukin 15 during the differentiation of uterine natural killer cells (2002) Proceedings of the 19th International Natural Killer Cell Workshop, , October 2002, San Juan, PRCroy, B.A., Chantakru, S., Esadeg, S., Ashkar, A.A., Wei, Q., Decidual natural killer cells: Key regulators of placental development (a review) (2002) J. Reprod. Immunol., 57, pp. 151-168Delgado, S.R., McBey, B.-A., Yamashiro, S., Fujita, J., Kiso, Y., Croy, B.A., Accounting for the peripartum loss of granulated metrial gland cells, a natural killer cell population, from the pregnant mouse uterus (1996) J. 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Selection of Genetically Modified Chicken Blastodermal Cells by Magnetic-Activated Cell Sorting
Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice
Uterine Natural Killer Cells: Insights Into Their Cellular And Molecular Biology From Mouse Modelling
In primates, including women, and in rodents, natural killer lymphocytes (NK cells) have a unique relationship with the decidualizing uterus. Implantation sites from genetically modified and transplanted mice have proven useful models for understanding potential mechanisms involved in the recruitment, activation and functions of human CD56bright uterine (u)NK cells. Key findings are reviewed in this article. In mice, uNK precursor cells are recruited from secondary lymphoid tissues and are activated coincident with their uterine arrival. uNK cells proliferate, produce cytokines (interferon gamma (IFN-γ) and interleukin 18 (IL-18) and IL-27), and terminally differentiate into granulated lymphocytes. Many uNK cells proliferate within the myometrium at each implantation site forming a structure, the mesometrial lymphoid aggregate of pregnancy (MLAp) that surrounds blood vessels servicing each placenta. Post-mitotic uNK cells are abundant within decidua basalis; frequently (> 25%) associating with spiral arteries, intramurally and intraluminally. From mid-gestation, numbers of uNK cells decline. Studies of implantation sites in mice lacking uNK cells, IFN-γ, components of IFN-γ-induction and -signalling pathways or IFN-γ-regulated genes indicate that uNK cell-derived IFN-γ is essential in triggering pregnancy-induced spiral artery modification. Decidual maintenance and uNK cell death are additional effects of uNK cell-derived IFN-γ. 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