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Presumed Neuroglycopenia Caused by Severe Hypoglycemia in Horses.
BackgroundNeuroglycopenia refers to a shortage of glucose in the brain resulting in neuronal dysfunction and death if left untreated. Presumed neuroglycopenia has not been described in horses.ObjectiveTo report neurological signs in horses with presumed neuroglycopenia as the result of severe hypoglycemia.AnimalsNinety horses (hours to 28 years of age) diagnosed with hypoglycemia (blood glucose concentration < 75 mg/dL [< 4.2 mmol/L]).MethodsRetrospective study. Electronic medical records were searched. Signalment, history, complaint, clinical signs, laboratory findings including CSF analysis, electroencephalogram, clinical or definitive diagnosis, and outcome were recorded. Kruskal-Wallis analysis of variance and logistic regression were used to investigate association between blood glucose concentration and data extracted. Statistical significance was set at P < 0.05.ResultsThirty-eight and 52 horses had mild (50-74 mg/dL [2.8-4.1 mmol/L]), and severe hypoglycemia (< 50 mg/dL [< 2.8 mmol/L]), respectively. Most common causes of hypoglycemia included liver and gastrointestinal (40%) disease, sepsis (33%), neoplasia (7%), and insulin-induced (4%). Most common neurologic deficits included obtundation (100%), seizures (42%), and disorientation (22%). CSF-glucose was severely low (mean 2.5 mg/dL [0.1 mmol/L], median 0 mg/dL). Paroxysmal discharges in support of seizures were identified in the occipital (visual) and parietal (closest to temporal-auditory) cortical regions upon EEG examination (8/8 horses).Conclusions and clinical importanceNeuroglycopenia is presumed to occur in horses as the result of severe hypoglycemia. Subclinical seizures, and intermittent blindness and deafness of cortical origin can occur. Severe altered state of consciousness and seizures can be observed at a blood glucose cut-off value of < 42 mg/dL (< 2.3 mmol/L)
Some issues concerning Large-Eddy Simulation of inertial particle dispersion in turbulent bounded flows
The problem of an accurate Eulerian-Lagrangian modeling of inertial particle
dispersion in Large Eddy Simulation (LES) of turbulent wall-bounded flows is
addressed. We run Direct Numerical Simulation (DNS) for turbulent channel flow
at shear Reynolds numbers equal to 150 and 300 and corresponding a-priori and
a-posteriori LES on differently coarse grids. We then tracked swarms of
different inertia particles and we examined the influence of filtering and of
Sub-Grid Scale (SGS) modeling for the fluid phase on particle velocity and
concentration statistics. We also focused on how particle preferential
segregation is predicted by LES. Results show that even ``well-resolved'' LES
is unable to reproduce the physics as demonstrated by DNS, both for particle
accumulation at the wall and for particle preferential segregation. Inaccurate
prediction is observed for the entire range of particles considered in this
study, even when the particle response time is much larger than the flow
timescales not resolved in LES. Both a-priori and a-posteriori tests indicate
that recovering the level of fluid and particle velocity fluctuations is not
enough to have accurate prediction of near-wall accumulation and local
segregation. This may suggest that reintroducing the correct amount of
higher-order moments of the velocity fluctuations is also a key point for SGS
closure models for the particle equation. Another important issue is the
presence of possible flow Reynolds number effects on particle dispersion. Our
results show that, in small Reynolds number turbulence and in the case of heavy
particles, the shear fluid velocity is a suitable scaling parameter to quantify
these effects
Clustering and collisions of heavy particles in random smooth flows
Finite-size impurities suspended in incompressible flows distribute
inhomogeneously, leading to a drastic enhancement of collisions. A description
of the dynamics in the full position-velocity phase space is essential to
understand the underlying mechanisms, especially for polydisperse suspensions.
These issues are here studied for particles much heavier than the fluid by
means of a Lagrangian approach. It is shown that inertia enhances collision
rates through two effects: correlation among particle positions induced by the
carrier flow and uncorrelation between velocities due to their finite size. A
phenomenological model yields an estimate of collision rates for particle pairs
with different sizes. This approach is supported by numerical simulations in
random flows.Comment: 12 pages, 9 Figures (revTeX 4) final published versio
A Schottky/2-DEG varactor diode for millimeter and submillimeter wave multiplier applications
A new Schottky diode is investigated for use as a multiplier element in the millimeter and submillimeter wavelength regions. The new diode is based on the Schottky contact at the edge of a 2-dimensional electron gas (2-DEG). As a negative voltage is applied to the Schottky contact, the depletion layer between the Schottky contact and the 2-DEG expands and the junction capacitance decreases, resulting in a nonlinear capacitance-voltage characteristic. In this paper, we outline the theory, design, fabrication, and evaluation of the new device. Recent results include devices having cutoff frequencies of 1 THz and above. Preliminary multiplier results are also presented
The decay of Hill's vortex in a rotating flow
Hill's vortex is a classical solution of the incompressible Euler equations which consists of an axisymmetric spherical region of constant vorticity matched to an irrotational external flow. This solution has been shown to be a member of a one-parameter family of steady vortex rings and as such is commonly used as a simple analytic model for a vortex ring. Here, we model the decay of a Hill's vortex in a weakly rotating flow due to the radiation of inertial waves. We derive analytic results for the modification of the vortex structure by rotational effects and the generated wave field using an asymptotic approach where the rotation rate, or inverse Rossby number, is taken to be small. Using this model, we predict the decay of the vortex speed and radius by combining the flux of vortex energy to the wave field with the conservation of peak vorticity. We test our results against numerical simulations of the full axisymmetric Navier–Stokes equations
Statistical properties of an ideal subgrid-scale correction for Lagrangian particle tracking in turbulent channel flow
One issue associated with the use of Large-Eddy Simulation (LES) to
investigate the dispersion of small inertial particles in turbulent flows is
the accuracy with which particle statistics and concentration can be
reproduced. The motion of particles in LES fields may differ significantly from
that observed in experiments or direct numerical simulation (DNS) because the
force acting on the particles is not accurately estimated, due to the
availability of the only filtered fluid velocity, and because errors accumulate
in time leading to a progressive divergence of the trajectories. This may lead
to different degrees of inaccuracy in the prediction of statistics and
concentration. We identify herein an ideal subgrid correction of the a-priori
LES fluid velocity seen by the particles in turbulent channel flow. This
correction is computed by imposing that the trajectories of individual
particles moving in filtered DNS fields exactly coincide with the particle
trajectories in a DNS. In this way the errors introduced by filtering into the
particle motion equations can be singled out and analyzed separately from those
due to the progressive divergence of the trajectories. The subgrid correction
term, and therefore the filtering error, is characterized in the present paper
in terms of statistical moments. The effects of the particle inertia and of the
filter type and width on the properties of the correction term are
investigated.Comment: 15 pages,24 figures. Submitted to Journal of Physics: Conference
Serie
Heavy particle concentration in turbulence at dissipative and inertial scales
Spatial distributions of heavy particles suspended in an incompressible
isotropic and homogeneous turbulent flow are investigated by means of high
resolution direct numerical simulations. In the dissipative range, it is shown
that particles form fractal clusters with properties independent of the
Reynolds number. Clustering is there optimal when the particle response time is
of the order of the Kolmogorov time scale . In the inertial range,
the particle distribution is no longer scale-invariant. It is however shown
that deviations from uniformity depend on a rescaled contraction rate, which is
different from the local Stokes number given by dimensional analysis. Particle
distribution is characterized by voids spanning all scales of the turbulent
flow; their signature in the coarse-grained mass probability distribution is an
algebraic behavior at small densities.Comment: 4 RevTeX pgs + 4 color Figures included, 1 figure eliminated second
part of the paper completely revise
Exploring the impact of Osteogenesis Imperfecta on families: A mixed-methods systematic review
Background: Osteogenesis Imperfecta (OI) is a rare genetic condition whose key characteristic is increased bone fragility. OI has the potential to impact upon all family members, making it important to consider the challenges families face, how they cope and their support needs as the affected individual moves from childhood through to adult life. /
Objective: To conduct a mixed-methods systematic review investigating the experiences of families when a family member is affected with OI. /
Methods: A systematic search of seven electronic databases, relevant patient organisation websites and reference lists was conducted. Data extraction was performed for all studies that met the eligibility and quality criteria. Results were synthesised following the principles of thematic analysis. /
Results: One mixed-method, six qualitative and six quantitative studies were included in the review. Three overarching themes were identified through thematic analysis: Impact of OI on the psychosocial wellbeing of families, impact on family life and evolving roles and relationships. Fear of fractures and the uncertainty of when the next fracture will occur are key issues that permeate all areas of family life and impact upon all family members. /
Conclusion: The experiences, coping strategies and support needs of families affected by OI were highly variable and changed over time. Future research should address the need for adaptive health and education interventions that support all family members
Better, Faster, Stronger: Integrating Archives Processing and Technical Services
The University of Denver’s Penrose Library implemented a consolidated cataloging and archives processing unit for all materials, taking advantage of the structure, workflow design, and staff resources that were already in place for library-wide materials processing: acquisitions, cataloging, binding, and stacks maintenance. The objective of Penrose Library’s integrated approach was to efficiently create metadata that allow searches based on subject relevance rather than on collection provenance. The library streamlined archives processing by integrating digital content creation and management into the materials processing workflow. The result is a flexible, sustainable, and scalable model for archives processing that utilizes existing staff by enhancing and extending the skills of both experienced monographs catalogers and archivists
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