Utilising Located Functions to Model and Optimise Distributed Computations

With developments in Grid computing and Web based data storage the task of orchestrating computations is becoming ever more difficult. Identifying which of the available computation resources and datasets to use is not trivial: it requires reasoning about the problem itself and the cost of moving data to complete the computation efficiently. This paper presents a conceptual notation and performance model that enables e-researchers to reason about their computations and make choices about the best use of resources

Towards Grid Interoperability

The Grid paradigm promises to provide global access to computing resources, data storage and experimental instruments. It also provides an elegant solution to many resource administration and provisioning problems while offering a platform for collaboration and resource sharing. Although substantial progress has been made towards these goals, nevertheless there is still a lot of work to be done until the Grid can deliver its promises. One of the central issues is the development of standards and Grid interoperability. Job execution is one of the key capabilities in all Grid environments. This is a well understood, mature area with standards and implementations. This paper describes some proof of concept experiments demonstrating the interoperability between various Grid environments

Analysis of the Venoms of Four Subspecies of the Western Rattlesnake (Crotalus oreganus)

Recently, the benefits venom can have in the discovery and development of different medications to assist in treating a variety of diverse human diseases have been areas of research. In order to develop a better understanding of how to evaluate venoms for potential use as therapeutics, one needs to look at the fundamental composition of venom samples. This project aims at discovering and analyzing the basic components from the venom of four different subspecies of the Western Rattlesnake. Venom samples collected will be subjected to size exclusion chromatography to separate proteins of different sizes. After fractionation of venoms, the following assays are conducted on individual fractions to locate specific activities of enzymatic venom proteins: metalloproteinase activity, kallikrein-like and thrombin-like serine proteinase activities, phospholipase A2 activity, phosphodiesterase activity and L-amino acid oxidase activity. These tests will compare the basic biochemistry of the samples of venoms from the different subspecies to help expand knowledge on chemistry differences between closely related subspecies of rattlesnakes. Snakes use their venoms primarily to obtain food, and results will allow for further evaluation of how their differing venom compositions relate to specific aspects of their ecology, such as use of divergent habitats, potential risks of different predators, effects on various prey species utilized, as well as revealing those components that have remained static and are shared among all subspecies analyzed. Because envenomation symptoms will vary due to venom composition, these results will also help inform what medical sequelae should be expected from particular populations of rattlesnakes

A rapid, chromatography-free route to substituted acridine–isoalloxazine conjugates under microwave irradiation

Microwave irradiation was applied to a sequence of condensation reactions from readily available 9-chloroacridines to provide a range of novel acridine–isoalloxazine conjugates. The combination of these two moieties, both of biological interest, was achieved by a chromatography free route

Teaching the Grid: Learning Distributed Computing with the M-grid Framework

A classic challenge within Computer Science is to distribute data and processes so as to take advantage of multiple computers tackling a single problem in a simultaneous and coordinated way. This situation arises in a number of different scenarios, including Grid computing which is a secure, service-based architecture for tackling massively parallel problems and creating virtual organizations. Although the Grid seems destined to be an important part of the future computing landscape, it is very difficult to learn how to use as real Grid software requires extensive setting up and complex security processes. M-grid mimics the core features of the Grid, in a much simpler way, enabling the rapid prototyping of distributed applications. We describe m-grid and explore how it may be used to teach foundation Grid computing skills at the Higher Education level and report some of our experiences of deploying it as an exercise within a programming course

The synthesis and study of poly(N-isopropylacrylamide)/poly(acrylic acid) interpenetrating polymer network nanoparticle hydrogels.

Homogeneous hydrogels made of an interpenetrating network of poly(N-isopropylacrylamide) (PNIPAm) and poly(acrylic acid) (PAAc) are synthesized by a two-step process; first making PNIPAm hydrogels and then interpenetrating acrylic acid throughout the hydrogel through polymerization. The kinetic growth of the IPN is plotted and an equation is fitted to the data. When diluted to certain concentrations in water, the hydrogels show reversible, inverse thermal gelation at about 34°C. This shows unique application to the medical field, as the transition is just below body temperature. A drug release experiment is performed using high molecular weight dyes, and a phase diagram is created through observation of the purified, concentrated gel at varying concentrations and temperatures

Short and Long-Term Success of a Surgery Residency Prep Course

Introduction. The aim of our study was to evaluate the short-term and long-term effectiveness a surgery residency prep course has throughout intern year. Methods.  A surgery residency prep course was offered to graduating medical students.  An anonymous survey assessing perceived confidence in medical knowledge, clinical skills and surgical skills was given pre-course, post-course and at 6 months into residency.   Participants also completed a pre and post course quiz. Results.  Eleven students completed the course and participated in a pre-course survey, 7 completed the post-course survey and 4 completed the 6-month survey.  Students felt significantly more confident for intern year following the course compared to before the course (4.0 vs. 2.7, p = 0.018).  Students were found to have no significant change in perceived confidence at 6 months compared to post-course results (4.0 vs. 3.9, p = 0.197).  Objectively, post course quiz results were significantly improved compared to pre course quiz results (12.9 vs. 10.6, p = 0.004). Conclusions.  This study demonstrates the long-term effects a surgery prep-course may have on residents entering a surgery residency.

The OMII Software Distribution

This paper describes the work carried out at the Open Middleware Infrastructure Institute (OMII) and the key elements of the OMII software distribution that have been developed in collaboration with members of the Managed Programme Initiative. The main objective of the OMII is to preserve and consolidate the achievements of the UK e-Science Programme by collecting, maintaining and improving the software modules that form the key components of a generic Grid middleware. Recently, the activity at Southampton has been extended beyond 2009 through a new project, OMII-UK, that forms a partnership that now includes the OGSA-DAI activities at Edinburgh and the myGrid project at Manchester

The Software Sustainability Institute:Changing Research Software Attitudes and Practices

To effect change, the Software Sustainability Institute works with researchers, developers, funders, and infrastructure providers to identify and address key issues with research software

Powering West Midlands Growth: A Regional Approach to Clean Energy Innovation

The West Midlands is uniquely positioned to lead the UK in taking advantage of the economic opportunities arising from the global transition to a clean energy system. The region’s strengths include: strong and coherent political leadership committed to sustainability; the diversity of economic needs and scale of demand required to build competitive markets to support radical innovation; a world-class concentration of both academic and commercial expertise in the low-carbon energy sector; a massive programme of public and private investment in infrastructure planned for the next decade, and above all, the determination to secure long-term economic benefit from clean energy innovation. This report makes the case for the creation of a small number of Energy Innovation Zones (EIZs) across the region, acting as pathfinders for an approach that might subsequently be adopted across the country as a whole. EIZs enable barriers – such as powerful institutional silos separating transport, digital, planning and energy – to be overcome within designated geographies. They create a risk-managed and commercial-scale context for the development of new local clean energy markets. They also provide a practical mechanism to help attract investment and muster local political support. At a national level, they can help ensure innovation is built into the government’s strategic sector deals and other large scale public investment projects