Will a man rob God? (Malachi 3:8): a Study of Tithing in the Old and New Testaments

Is tithing, that is, giving ten percent of one\u27s income, obligatory for Christians? This first in a series of two articles investigates this question by studying all references to tithing in Scripture. The discussion commences with OT references to tithing prior to the giving of the Mosaic Law, then in the Mosaic Low, the historical, and the prophetic books. This is followed by a study of the three major NT passages on tithing. This article concludes that none of the OT or NT passages can legitimately be used to argue for the continuation of tithing in the new covenant period

An Analysis of the Arguments for the Dating of the Fourth Gospel

There are various arguments for the date of composition of the Fourth Gospel. Forty-one lines of argument will be discussed below. The date of the Fourth Gospel will have significance for how one views the purpose statement, the occasion for writing, the author, and the location of origin (providence). At times one\u27s interpretation may be influenced by how one decides on a date and vice-versa. The discussion will be broken into four sections: the argument for a pre A. D. 70 date, post-A.D. 70 date, pre-A.D. 100 date, and post-A.D. 100 date. In each section, the discussion will move from the external to the internal evidence and will be placed in the order of least persuasive to most persuasive. The conclusion will determine the most compelling evidence for each category and decide on a date of composition for the Fourth Gospel (FG) which appears to be most supported by the evidence

Reconstructing a Biblical Model of Giving: a Discussion of Relevant Systematic Issues and New Testament Principles

In a previous article the authors discussed all relevant references to tithing in Scripture and concluded that the continuation of a tithing requirement cannot be adequately supported by the exegesis of individual texts. In the present article, we assess the applicability of tithing in light of pertinent systematic issues. Following a discussion of the relationship between the Mosaic Law and the new covenant, larger systematic issues that have been used to argue for the continuation of tithing are analyzed and criticized. The article concludes with a survey of NT principles for giving

An Analysis of the Concept of Believing in the Narrative Contexts of John\u27s Gospel

The thesis explores the meaning of the concept of believing in the Gospel of John. Chapter 1 provides a discussion of the relevance of the subject and the methodology employed in the research. The methodology is primarily a semantic field approach emphasizing the importance context adds to the interpretation process. Chapters 2, 3, and 4 follow the same basic outline. The goal is to provide an analysis of [Special characters omitted.] within its syntactical relationships and verbal forms. Any relevant conclusions are then integrated into an exegetical discussion. The Gospel of John is divided into three sections, one for each of these chapters: John 1-4, 5-12, 13-21. In Chapter 2 (John 1-4) the evidence for interchangeableness of the [Special characters omitted.] and [Special characters omitted.] + dative constructions is presented. [Special characters omitted] constructions do not refer to a superior belief. Typically, verbal forms of [Special characters omitted.] are not used formulaically. The crowd in 2:23-25 is portrayed negatively. The disciples, the Samaritans, and the royal official progressed in their belief. In Chapter 3 (John 5-12) the [Special characters omitted.] construction was determined to contain a different meaning than the [Special characters omitted.] and [Special characters omitted.] + dative constructions. John 5:12 can be characterized as, largely, many people rejecting Jesus. While four signs were performed by Jesus, there were seven negative reactions to them; the three signs performed in John 1-4 had mixed reactions. Three inadequate professions were made in John 5-12 (6:14; 7:31; 10:21) and four groups demonstrated deficient belief through poor actions (6:22-66; 8:21-47; 10:22-39; 12:42-43). Positive portrayals were placed in contrast to negative portrayals. The antecedent to “they” (in 12:37) are the negative portrayals of those believing in John’s Gospel, not one specific group. In Chapter 4 (John 13-21) the [Special characters omitted.] absolute construction was in a synonymous relationship to a [Special characters omitted.] construction, demonstrating the flexibility of this construction in the Gospel. Eternal life, understood in both its qualitative and quantitiative aspects, was discussed in its relationship to believing. The relationship of knowing and believing should be understood as being reciprocal. John 13-21 begins with two pericopae in which Jesus calls his disciples into a deeper faith; later in the narrative they progress. All portrayals of believing were positive in this section. It appears that the beginning of the Gospel was more concerned with a question of whom belief should be placed in, while the latter part was more concerned with the content of this belief. Chapter 5 summarizes the conclusions while integrating them. Implications are drawn for Lordship Salvation and the doctrine of assuranc

A Biblical and Theological Analysis of Tithing: Toward a Theology of Giving in the New Covenant Era

Chapter 1 summarized some of the methodological and hermeneutical issues and discussed the problem and history of tithing in Christianity. Various arguments through the centuries have been proposed that provided reasons for the abrogation and the continuation of tithing. The Christian view on this issue has not been monolithic. Chapter 2 discussed tithing in the Old Testament and concluded that (1) the pre-Mosaic period contained no tithing system and no command to tithe, (2) in the Mosaic law the Israelites gave well-beyond ten percent and only products connected to the land were liable to tithing, and (3) the Historical and Prophetic books contain no passage useful to argue for the continuation of tithing. Chapter 3 explicated the teaching of tithing in the New Testament. The passages that employ the word tithe in no way advocate the continuation of tithing for Christians. Chapter 4 analyzed three theological systems and concluded that arguments from these theological systems to advocate tithing fell short of convincing. The systems of dispensationalism and Non-Theonomic Covenant Theology do not contain principles that lead to the continuation of tithing. Theonomic Covenant Theology may possibly advocate the Charity Tithe, if they believe it is part of the civil law. Finally, traditionalism, pragmatism, and natural law furnished inconclusive arguments for the continuation of tithing. Chapter 5 discerned five categories for New Covenant era giving. The twenty principles elucidated are a foundation from which Christian giving can be faithfully observed. Above all, these principles require that one have an active relationship with the Lord for obedience to result. The standard has not been lowered, but neither has it necessarily been raised: it has changed. All Christians should give something, but there is not a universal amount or percentage required. Each believer must look at their situation in life, their church, and those around them to seek out possible needs. Furthermore, a mindset focused on eternity, and not the moment, will desire to give sacrificially to God\u27s work on the earth. From some paychecks God may require one hundred percent, from others five percent

How many steps/day are enough? For older adults and special populations

Older adults and special populations (living with disability and/or chronic illness that may limit mobility and/or physical endurance) can benefit from practicing a more physically active lifestyle, typically by increasing ambulatory activity. Step counting devices (accelerometers and pedometers) offer an opportunity to monitor daily ambulatory activity; however, an appropriate translation of public health guidelines in terms of steps/day is unknown. Therefore this review was conducted to translate public health recommendations in terms of steps/day. Normative data indicates that 1) healthy older adults average 2,000-9,000 steps/day, and 2) special populations average 1,200-8,800 steps/day. Pedometer-based interventions in older adults and special populations elicit a weighted increase of approximately 775 steps/day (or an effect size of 0.26) and 2,215 steps/day (or an effect size of 0.67), respectively. There is no evidence to inform a moderate intensity cadence (i.e., steps/minute) in older adults at this time. However, using the adult cadence of 100 steps/minute to demark the lower end of an absolutely-defined moderate intensity (i.e., 3 METs), and multiplying this by 30 minutes produces a reasonable heuristic (i.e., guiding) value of 3,000 steps. However, this cadence may be unattainable in some frail/diseased populations. Regardless, to truly translate public health guidelines, these steps should be taken over and above activities performed in the course of daily living, be of at least moderate intensity accumulated in minimally 10 minute bouts, and add up to at least 150 minutes over the week. Considering a daily background of 5,000 steps/day (which may actually be too high for some older adults and/or special populations), a computed translation approximates 8,000 steps on days that include a target of achieving 30 minutes of moderate-to-vigorous physical activity (MVPA), and approximately 7,100 steps/day if averaged over a week. Measured directly and including these background activities, the evidence suggests that 30 minutes of daily MVPA accumulated in addition to habitual daily activities in healthy older adults is equivalent to taking approximately 7,000-10,000 steps/day. Those living with disability and/or chronic illness (that limits mobility and or/physical endurance) display lower levels of background daily activity, and this will affect whole-day estimates of recommended physical activity

Biological, clinical and population relevance of 95 loci for blood lipids.

Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol and triglycerides are among the most important risk factors for coronary artery disease (CAD) and are targets for therapeutic intervention. We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry. Here we report 95 significantly associated loci (P < 5 x 10(-8)), with 59 showing genome-wide significant association with lipid traits for the first time. The newly reported associations include single nucleotide polymorphisms (SNPs) near known lipid regulators (for example, CYP7A1, NPC1L1 and SCARB1) as well as in scores of loci not previously implicated in lipoprotein metabolism. The 95 loci contribute not only to normal variation in lipid traits but also to extreme lipid phenotypes and have an impact on lipid traits in three non-European populations (East Asians, South Asians and African Americans). Our results identify several novel loci associated with plasma lipids that are also associated with CAD. Finally, we validated three of the novel genes-GALNT2, PPP1R3B and TTC39B-with experiments in mouse models. Taken together, our findings provide the foundation to develop a broader biological understanding of lipoprotein metabolism and to identify new therapeutic opportunities for the prevention of CAD

Surgical perspectives from a prospective, nonrandomized, multicenter study of breast conserving surgery and adjuvant electronic brachytherapy for the treatment of breast cancer

<p>Abstract</p> <p>Background</p> <p>Accelerated partial breast irradiation (APBI) may be used to deliver radiation to the tumor bed post-lumpectomy in eligible patients with breast cancer. Patient and tumor characteristics as well as the lumpectomy technique can influence patient eligibility for APBI. This report describes a lumpectomy procedure and examines patient, tumor, and surgical characteristics from a prospective, multicenter study of electronic brachytherapy.</p> <p>Methods</p> <p>The study enrolled 65 patients of age 45-84 years with ductal carcinoma or ductal carcinoma in situ, and 44 patients, who met the inclusion and exclusion criteria, were treated with APBI using the Axxent^®electronic brachytherapy system following lumpectomy. The prescription dose was 34 Gy in 10 fractions over 5 days.</p> <p>Results</p> <p>The lumpectomy technique as described herein varied by site and patient characteristics. The balloon applicator was implanted by the surgeon (91%) or a radiation oncologist (9%) during or up to 61 days post-lumpectomy (mean 22 days). A lateral approach was most commonly used (59%) for insertion of the applicator followed by an incision site approach in 27% of cases, a medial approach in 5%, and an inferior approach in 7%. A trocar was used during applicator insertion in 27% of cases. Local anesthetic, sedation, both or neither were administered in 45%, 2%, 41% and 11% of cases, respectively, during applicator placement. The prescription dose was delivered in 42 of 44 treated patients.</p> <p>Conclusions</p> <p>Early stage breast cancer can be treated with breast conserving surgery and APBI using electronic brachytherapy. Treatment was well tolerated, and these early outcomes were similar to the early outcomes with iridium-based balloon brachytherapy.</p

Effect of imaging and catheter characteristics on clinical outcome for patients in the PRECISE study

The PRECISE study used convection enhanced delivery (CED) to infuse IL13-PE38QQR in patients with recurrent glioblastoma multiforme (GBM) and compared survival to Gliadel Wafers (GW). The objectives of this retrospective evaluation were to assess: (1) catheter positioning in relation to imaging features and (2) to examine the potential impact of catheter positioning, overall catheter placement and imaging features on long term clinical outcome in the PRECISE study. Catheter positioning and overall catheter placement were scored and used as a surrogate of adequate placement. Imaging studies obtained on day 43 and day 71 after resection were each retrospectively reviewed. Catheter positioning scores, catheter overall placement scores, local tumor control and imaging change scores were reviewed and correlated using Generalized Linear Mixed Models. Cox PH regression analysis was used to examine whether these imaging based variables predicted overall survival (OS) and progression free survival (PFS) after adjusting for age and KPS. Of 180 patients in the CED group, 20 patients did not undergo gross total resection. Of the remaining 160 patients only 53% of patients had fully conforming catheters in respect to overall placement and 51% had adequate catheter positioning scores. Better catheter positioning scores were not correlated with local tumor control (P = 0.61) or imaging change score (P = 0.86). OS and PFS were not correlated with catheter positioning score (OS: P = 0.53; PFS: P = 0.72 respectively), overall placement score (OS: P = 0.55; PFS: P = 0.35) or imaging changes on day 43 MRI (P = 0.88). Catheter positioning scores and overall catheter placement scores were not associated with clinical outcome in this large prospective trial

A haplotype variation affecting the mitochondrial transportation of hMYH protein could be a risk factor for colorectal cancer in Chinese

<p>Abstract</p> <p>Background</p> <p>The human MutY homolog (<it>hMYH</it>), a DNA glycolsylase involved in the excision repair of oxidative DNA damage, is currently studied in colorectal cancer (CRC). We previously demonstrated a haplotype variant c.53C>T/c.74G>A of <it>hMYH </it>(T/A) increasing the risk for gastric cancer in Chinese. However, most investigations on correlation between <it>hMYH </it>and CRC are conducted in Western countries and the underlying mechanism has been poorly understood.</p> <p>Methods</p> <p>To determine whether the haplotype T/A variant of <it>hMYH </it>was related to colorectal carcinogenesis, we performed a case-control study in 138 colorectal cancer (CRC) patients and 343 healthy controls in a Chinese population. Furthermore, the C/G for wild-type, C/A or T/G for single base variant and T/A for haplotype variant <it>hMYH </it>cDNAs with a flag epitope tag were cloned into pcDNA3.1+ vector and transfected into cos-7 cell line. Their subcellular localizations were determined by immunofluorescence assay.</p> <p>Results</p> <p>It was found that the frequency of haplotype variant allele was statistically higher in CRC patients than that in controls (<it>P </it>= 0.02, odds ratio = 5.06, 95% confidence interval = 1.26 – 20.4). Similarly, significant difference of heterozygote frequency was indicated between the two groups (<it>P </it>= 0.019), while no homozygote was found. In addition, immunofluorescence analysis showed that hMYH protein with haplotype T/A variation presented in both nucleus and mitochondria, in contrast to the wild-type protein only converging in mitochondria. However, neither of the single missense mutations alone changed the protein subcelluar localization.</p> <p>Conclusion</p> <p>Although preliminarily, these results suggest that: the haplotype variant allele of <it>hMYH </it>leads to a missense protein, which partly affects the protein mitochondrial transportation and results as nuclear localization. This observation might be responsible for the increased susceptibility to cancers, including CRC, in Chinese.</p