Numerical Simulation of the Behavior of Cracked Reinforced Concrete Members

Refined non-linear static or dynamic analyses of reinforced concrete structures require the knowledge of the actual force-displacement or bending moment-rotation curves of each structural member, which depend on the crack widths and on the crack pattern, and after all on the slip between concrete and reinforcing steel. For this reason the definition of improved local models taking into account all these local aspects is a fundamental prerequisite for advanced assessment of r.c. structures. A numerical procedure which allows to predict the relative displacement between steel reinforcement and the surrounding concrete in a reinforced concrete element, once assigned the stress in the naked steel bar and the bond-slip law is discussed. The method provides as final outcomes the sequence of crack openings and the individual crack widths, regardless of the particular bond-slip correlation adopted. The proposed procedure is implemented referring to two relevant experimental case studies, demonstrating that it is able to predict satisfactorily actual strain fields and slips along the investigated reinforced concrete elements

Analysis of Dam Behaviour After Eighty Years of Service

The paper reports on the behaviour of a masonry dam built in the Italian Alps in the early twenties of the last century and still in operation for electric power supply. The dam is 31 m high and its waterproofing is ensured by a multi-layered impervious facing, a concrete cut-off and a grout curtain protruding into the foundation soils. The geological location of the dam is rather complex, because its left abutment is located on a rock formation while the right one rests on a thick moraine deposit. Since its first impounding, large downstream water flows and significant movements of the dam and of its moraine abutment were observed. A comprehensive investigation has thus been conducted in order to understand the overall behaviour of the reservoir, after eighty years of service. For this purpose, historical documents have been first reviewed in order to reconstruct the design assumptions, construction operations and early observations on site. Experimental investigations of the moraine deposit have then been conducted, in order to estimate the subsoil properties. Seepage flow rates and reservoir impoundment levels, recorded for more then twenty years, have also been analysed, showing the correlation existing between these two variables. More recently, a system for monitoring the displacements of the dam and the moraine has been implemented and the recorded data have been examined. All the available observations have been evaluated and a reasonable interpretation of the coupled hydraulical-mechanical behaviour of the dam and of its moraine abutment has been inferred. Numerical calculations have finally been conducted, in order to verify such explanation

Reliability of roof structures subjected to snow loads

A proper evaluation of snow loads on roofs is crucial for structural design especially to guarantee an adequate reliability level of lightweight roof structures. The definition of roof snow load in structural codes is based on both the evaluation of ground snow loads and conversion factors from ground to roof load, which are function of the roof’s geometry, its exposure to wind and its thermal properties. However, reference values of roof snow loads are based only on an extreme value analysis carried out to derive characteristic values of ground snow load, while conversion factors are considered as deterministic quantities due to the lack of the data. In this paper, first a methodology to evaluate the reference value of roof snow load is presented based on the definition of probability density functions for ground snow loads and conversion factors accounting for roof’s geometry and its exposure to wind. The results lead to the definition of a design conversion factor which depend on the coefficient of variation of ground snow loads and are compared with the constant values provided by the Eurocode models, in EN1991-1-3:2003. Then, structural reliability is assessed for reference steel and timber structures located in different sites. Considering different proportions between variable and permanent loads, the reliability of flat roofs designed according to Eurocode provisions, provided by the current version and the new draft, is finally compared with the required target reliability levels

Probabilistic methodology for the assessment of the impact of climate change on structural safety

Structural design is often governed by climatic actions, such as snow, wind, thermal and atmospheric icing loads, that will occur during the design service life. Since in structural standards climatic actions are usually derived from historical data series assuming stationary climate, alterations induced by climate change should be specifically evaluated, also to assess their influence on structural reliability. In the paper, a probabilistic methodology for the assessment of climate change impact on long-term structural reliability is presented, based on the analysis of observed data series and climate projections, provided by high resolution climate models. Factor of change uncertainty maps for climate extremes are derived starting from the analysis of weather series generated by an ad hoc weather generator, which considers homogenous populations of data suitably derived from climate model output. The long-term structural reliability is then assessed for reference structures at a given site considering the non-stationary nature of climatic actions by means of the pdfs of changes in extreme value parameters. Specifically, variations of the failure probability with time due to climate change are evaluated by moving time windows of forty years considering changes in mean load intensity and standard deviation of yearly maxima of the investigated climatic action. The results show the capability of the method to assess the impact of climate change on structural safety, highlighting the necessity of adaptation measure to maintain the required target reliability of the structure during its life

Extreme ground snow loads in Europe from 1951 to 2100

Lightweight roofs are extremely sensitive to extreme snow loads, as confirmed by recently occurring failures all over Europe. Obviously, the problem is further emphasized in warmer climatic areas, where low design values are generally foreseen for snow loads. Like other climatic actions, representative values of snow loads provided in structural codes are usually derived by means of suitable elaborations of extreme statistics, assuming climate stationarity over time. As climate change impacts are becoming more and more evident over time, that hypothesis is becoming controversial, so that suitable adaptation strategies aiming to define climate resilient design loads need to be implemented. In the paper, past and future trends of ground snow load in Europe are assessed for the period 1950–2100, starting from high-resolution climate simulations, recently issued by the CORDEX program. Maps of representative values of snow loads adopted for structural design, associated with an annual probability of exceedance p = 2%, are elaborated for Europe. Referring to the historical period, the obtained maps are critically compared with the current European maps based on observations. Factors of change maps, referred to subsequent time windows are presented considering RCP4.5 and RCP8.5 emission trajectories, corresponding to medium and maximum greenhouse gas concentration scenarios. Factors of change are thus evaluated considering suitably selected weather stations in Switzerland and Germany, for which high quality point measurements, sufficiently extended over time are available. Focusing on the investigated weather stations, the study demonstrates that climate models can appropriately reproduce historical trends and that a decrease of characteristic values of the snow loads is expected over time. However, it must be remarked that, if on one hand the mean value of the annual maxima tends to reduce, on the other hand, its standard deviation tends to increase, locally leading to an increase of the extreme values, which should be duly considered in the evaluation of structural reliability over time

Climate Change: impact on snow loads on structures

A general procedure to evaluate future trends in snow loads on structures is illustrated aiming to study influences of climate change at European scale, to assess its impact on the design of new structures as well as on the reliability levels of existing ones, also in view of the next revision of the Eurocodes. Analysing high quality registered meteorological data of daily temperatures, rain and snow precipitations in nine Italian weather stations, conditional probability functions of occurrence of snow precipitation, accumulation and melting have been preliminarily determined as functions of daily air temperatures. By means of Monte Carlo simulations and based upon daily output of climate models (daily max. and min. temperatures and water precipitation) yearly maxima of snow loads for various time intervals of 40 years in the period 1980-2100 have been simulated, deriving, via the extreme value theory, the characteristic ground snow loads at the sites. Then, the proposed procedure has been implemented in a more general methodology for snow map updating, in such a way that the influence of gridded data of precipitation, predicted by global climate models, on extreme values of snow loads is duly assessed. Preliminary results demonstrate that the outlined procedure is very promising and allows to estimate the evolution of characteristic ground snow loads and to define updated ground snow load maps for different climate models and scenarios

A Case of Lymphocytic Leukemia in a Bearded Dragon (Pogona Vitticeps) and a Review of Literature

The present paper reports the case of a 3 years old, female Bearded Dragon (Pogona vitticeps) presenting lethargy, anorexia,weight loss, and anemia and marked leukocytosis at CBC. The majority of leukocytes were lymphocytic/lymphoblastic cells (97%). Immunocytochemical staining of blood smears marked for CD3 (neg) and CD79a (pos) suggested immunophenotype B. The patient died after one month from diagnosis. Histology evidenced lymphoid infi ltration in the heart, spleen, liver, kidneys and gut. In addition, in the bone marrow a massive infi ltration of lymphoid cells confi rmed the diagnosis of leukemia. Immunohistochemistry confi rmed the CD79a positivity of a large part of infi ltrating lymphoid cells indicating a B cells immunophenotype of the neoplastic population. The presence of lymphocytosis and multiorgan infi ltration supported the diagnosis of lymphocytic leukemia. Finally, a revision of the literature has also been mad

Ultra-thin oxide breakdown for OTP development in power technologies

AbstractOTP (One Time Programmable) memory in power technology enables electrical performance optimization together with area occupation reduction. In this paper, the aspects relative to the oxide breakdown (which is the key mechanism for memory programmability) are studied and applied to the development of an antifuse OTP cell in a 350 nm-CMOS power technology. The physical analysis of the degradation phases of an oxide layer is presented together with the physical models, exploited to foresee the device time-to-breakdown depending on applied voltage, oxide thickness etc. The achieved results are used in the development and reliable implementation of OTP cells in the target 350 nm-CMOS node

MicroRNAs in melanoma development and resistance to target therapy

microRNAs constitute a complex class of pleiotropic post-transcriptional regulators of gene expression involved in the control of several physiologic and pathologic processes. Their mechanism of action is primarily based on the imperfect matching of a seed region located at the 5' end of a 21-23 nt sequence with a partially complementary sequence located in the 3' untranslated region of target mRNAs. This leads to inhibition of mRNA translation and eventually to its degradation. Individual miRNAs are capable of binding to several mRNAs and several miRNAs are capable of influencing the function of the same mRNAs. In recent years networks of miRNAs are emerging as capable of controlling key signaling pathways responsible for the growth and propagation of cancer cells. Furthermore several examples have been provided which highlight the involvement of miRNAs in the development of resistance to targeted drug therapies. In this review we provide an updated overview of the role of miRNAs in the development of melanoma and the identification of the main downstream pathways controlled by these miRNAs. Furthermore we discuss a group of miRNAs capable to influence through their respective up- or down-modulation the development of resistance to BRAF and MEK inhibitors

MicroRNA dysregulation and esophageal cancer development depend on the extent of zinc dietary deficiency

open9siopenFong, Louise Y.; Taccioli, Cristian; Jing, Ruiyan; Smalley, Karl J.; Alder, Hansjuerg; Jiang, Yubao; Fadda, Paolo; Farber, John L.; Croce, Carlo M.Fong, Louise Y.; Taccioli, Cristian; Jing, Ruiyan; Smalley, Karl J.; Alder, Hansjuerg; Jiang, Yubao; Fadda, Paolo; Farber, John L.; Croce, Carlo M