Prevalence and factors associated with parental concerns about development detected by the Parents' Evaluation of Developmental Status (PEDS) at 6-month, 12-month and 18-month well-child checks in a birth cohort

Objectives: Early identification of developmental vulnerability is vital. This study aimed to estimate the prevalence of moderate or high developmental risk on the Parents' Evaluation of Developmental Status (PEDS) at 6-month, 12-month and 18-month well-child checks; identify associated risk factors; and examine documentation of the PEDS at well-child checks. Design, participants: A prospective birth cohort of 2025 children with 50% of those approached agreeing to participate. Demographic data were obtained via questionnaires and linked electronic medical records. Telephone interviews were conducted with parents to collect PEDS data. Primary and secondary outcomes: Multiple logistic regression analyses identified risk factors for moderate or high developmental risk on the PEDS. A Cumulative Risk Index examined the impact of multiple risk factors on developmental risk and documentation of the PEDS at the well-child checks. Results: Of the original cohort, 792 (39%) had 6-month, 649 (32%) had 12-month and 565 (28%) had 18-month PEDS data. Parental concerns indicating moderate or high developmental risk on the PEDS were 27% (95% CI 24 to 30) at 6 months, 27% (95% CI 24 to 30) at 12 months and 33% (95% CI 29 to 37) at 18 months. Factors associated with moderate or high developmental risk were perinatal risk (OR 12 months: 1.7 (95% CI 1.1 to 2.7)); maternal Middle Eastern or Asian nationality (OR 6 months: 1.6 (95% CI 1.1 to 2.4)), (OR 12 months: 1.7 (95% CI 1.1 to 2.7)); and household disadvantage (OR 6 months: 1.5 (95% CI 1.0 to 2.2). As the number of risk factors increased the odds increased for high or moderate developmental risk and no documentation of the PEDS at well-child checks. Conclusions: Children with multiple risk factors are more likely to have parental concerns indicating

Cyclin A triggers Mitosis either via the Greatwall kinase pathway or Cyclin B

Two mitotic cyclin types, cyclin A and B, exist in higher eukaryotes, but their specialised functions in mitosis are incompletely understood. Using degron tags for rapid inducible protein removal, we analyse how acute depletion of these proteins affects mitosis. Loss of cyclin A in G2-phase prevents mitotic entry. Cells lacking cyclin B can enter mitosis and phosphorylate most mitotic proteins, because of parallel PP2A:B55 phosphatase inactivation by Greatwall kinase. The final barrier to mitotic establishment corresponds to nuclear envelope breakdown, which requires a decisive shift in the balance of cyclin-dependent kinase Cdk1 and PP2A:B55 activity. Beyond this point, cyclin B/Cdk1 is essential for phosphorylation of a distinct subset of mitotic Cdk1 substrates that are essential to complete cell division. Our results identify how cyclin A, cyclin B and Greatwall kinase coordinate mitotic progression by increasing levels of Cdk1-dependent substrate phosphorylation

No evidence for the Mozart effect in children

The Mozart effect refers to claims that listening to Mozart-like music results in a small, short-lived improvement in spatiotemporal performance. Based on predominantly adult research that has shown equivocal findings, there has been speculation that the Mozart effect may have pedagogical benefits for children. The present study aimed to examine the Mozart effect in children and to evaluate two alternative models proposed to account for the effect, namely the trion model and the arousal-mood model. One hundred and thirty-six Grade 5 students (mean age 10.7 years) were exposed to three experimental listening conditions: Mozart piano sonata K. 448, popular music, and silence. Each condition was followed by a spatiotemporal task, and mood and music questionnaires. The results showed no evidence of a Mozart effect. Speculation about applications of the Mozart effect in children needs to be suspended until an effect can be reliably reproduced.30

Clinical outcomes of an early intervention program for preschool children with Autism Spectrum Disorder in a group setting

ABSTRACT: BACKGROUND: Available evidence indicates that early intervention programs, such as the Early Start Denver Model (ESDM), can positively affect key outcomes for children with Autism Spectrum Disorder (ASD). However, programs involving resource intensive one-to-one clinical intervention are not readily available or deliverable in the community, resulting in many children with ASD missing out on evidence-based intervention during their early and most critical preschool years. This study evaluated the effectiveness of the ESDM for preschool-aged children with ASD using a predominantly group-based intervention in a community child care setting.METHODS: Participants were 26 children (21 male) with ASD with a mean age of 49.6 months. The ESDM, a comprehensive early intervention program that integrates applied behaviour analysis with developmental and relationship-based approaches, was delivered by trained therapists during the child's attendance at a child care centre for preschool-aged children with ASD. Children received 15--20 hours of group-based, and one hour of one-to-one, ESDM intervention per week. The average intervention period was ten months. Outcome measures were administered pre- and post-intervention, and comprised a developmental assessment - the Mullen Scales of Early Learning (MSEL); and two parent-report questionnaires - the Social Communication Questionnaire (SCQ) and Vineland Adaptive Behaviours Scales--Second Edition (VABS-II).RESULTS: Statistically significant post-intervention improvements were found in children's performance on the visual reception, receptive language and expressive language domains of the MSEL in addition to their overall intellectual functioning, as assessed by standardised developmental quotients. Parents reported significant increases in their child's receptive communication and motor skills on the VABS-II, and a significant decrease in autism-specific features on the SCQ. These effects were of around medium size, and appeared to be in excess of what may have been expected due to maturation. Nonetheless, these results need to be confirmed in a controlled study.CONCLUSIONS: This study suggests community dissemination of ESDM using predominantly group-based intervention may be an effective intervention. Making ESDM accessible to the wider ASD community in child care settings has the potential for significant clinical and economic benefits. Further studies are indicated in this area, including those with younger children, and which incorporate a control group and standardised ASD assessments.Trial registration: This trial is registered with the Australian New Zealand Clinical Trials Registry: Registry number ACTRN12612000461897

The cognitive and academic benefits of music to children : facts and fiction

There is considerable interest in the potential non‐musical cognitive and academic benefits of music listening and instruction to children. This report describes three lines of research relevant to this issue, namely, the effects of: (1) focused music listening on subsequent task performance (the Mozart effect); (2) music instruction; and (3) background music listening. Research suggests that while Mozart effect studies have attracted considerable media attention, the effect cannot be reliably demonstrated in children. In contrast, music instruction confers consistent benefits for spatiotemporal reasoning skills; however, improvements in associated academic domains, such as arithmetic, have not been reliably shown. Finally, background music may calm and focus children with special education needs, thereby enhancing learning. Additional research is required to determine whether this effect is evident in normal populations. Overall, evidence for the non‐musical benefits of music listening and instruction is limited. The inherent value of music and music education should not be overlooked by narrowly focusing on cognitive and academic outcomes

No evidence for the Mozart effect in children

The Mozart effect refers to claims that listening to Mozart-like music results in a small, short-lived improvement in spatiotemporal performance. Based on predominantly adult research that has shown equivocal findings, there has been speculation that the Mozart effect may have pedagogical benefits for children. The present study aimed to examine the Mozart effect in children and to evaluate two alternative models proposed to account for the effect, namely the trion model and the arousal-mood model. One hundred and thirty-six Grade 5 students (mean age = 10.7 years) were exposed to three experimental listening conditions: Mozart piano sonata K. 448, popular music, and silence. Each condition was followed by a spatiotemporal task, and mood and music questionnaires. The results showed no evidence of a Mozart effect. Speculation about applications of the Mozart effect in children needs to be suspended until an effect can be reliably reproduced

Positive parenting by parents of children up to three years of age: development and validation of measurement scales Ejercicio parental positivo por los padres de niños hasta tres años: construcción y validación de escalas de medición Exercício da parentalidade positiva pelos pais de crianças até três anos: construção e validação de escalas de medida

This study aimed to describe the development and validation of three multidimensional scales in which the same 30 items, distributed among five dimensions, measure parents' self-perceived confidence, difficulties and knowledge needs in the exercise of positive parenting during the first three years of the child's life. The content of the scales resulted from the literature and exploratory studies and was validated by experts. The analysis of its reliability and validity, using Pearson's correlations and Cronbach's alpha, was based on data from a questionnaire administered to a non-probabilistic sample of 1011 parents. In the dimensions and items, &#945;-values ranged between 0.769 and 0.890 and r-coefficients were >0.37;p <0.01. It was concluded that the scales measure three variables that correspond to the practice of positive parenting and their use permits guiding nursing support.<br>Este estudio tuvo el objetivo de describir la construcción y validación de tres escalas multidimensionales en que los mismos 30 ítems, distribuidos en 5 dimensiones, miden la auto-percepción de la confianza, de las dificultades y de la necesidad de conocimientos de los padres en el ejercicio parental positivo en los primeros tres años del niño. El contenido de las escalas resultó de la literatura y de estudios de explotación y fue validado por expertos. El análisis de su fidelidad y validez partió de los resultados de un cuestionario aplicado la una muestra no probabilística de 1011 padres. En las dimensiones e ítems, los valores de Coeficiente Alfa de Cronbach se situaron entre 0,769 y 0,890 y los de fueron >0,37; p<0,01. Se concluyó que las escalas miden tres variables que hacen operacional el ejercicio parental positivo y su utilización permite direccionar el apoyo de enfermería.<br>Os objetivos deste estudo foram descrever a construção e obtenção de algumas evidências de validade de três escalas multidimensionais em que os mesmos 30 itens, distribuídos por cinco dimensões, medem a autoperceção da confiança, das dificuldades e da necessidade de conhecimentos dos pais no exercício da parentalidade positiva, nos primeiros três anos da criança. O conteúdo das escalas resultou da literatura e de estudos exploratórios e foi validado por peritos. A análise da sua fidedignidade e validade, por meio de correlações de Pearson e coeficiente alfa de Cronbach, partiu dos resultados de um questionário aplicado a uma amostra não probabilística de 1.011 pais. Nas dimensões e itens, os valores de &#945; situaram-se entre 0,769 e 0,890 e os de r foram >0,37; p<0,01. Concluiu-se que as escalas medem três variáveis que operacionalizam o exercício da parentalidade positiva, e a sua utilização permite direcionar o apoio de enfermagem