The determinants of the academic outcome: an Bayesian approach using a sample of economics students from the University of Brasilia, Brazil

Using a survey conduct with 240 Economics students of the University of Brasília in August, 2011, this paper explores the determinants of the academic outcome, measured as the Gross Point Average of the University. The econometric method used to estimate is Ordinary Least Squares with Bayesian Inference. The explanatory variables include the habits of the students, such as study, frequency to classes and frequency to parties (the last one is a new approach in Brazil). Also, dummies of gender, work, type of high school and quota student were added. Study and frequency to classes turned out to be the most important determinants. The frequency to parties have not affected the Gross Point Average. The dummies had different results according to the group. There were no divergence with the major prior beliefs, with just one small exception

The Persistent Inequality in the Great Brazilian Cities: The Case of Brasília

Using the censuses of 2000 and 2010, we have noticed that the inequality of the household per capita income in the biggest Brazilian cities did not show a trend of reduction, differently from the whole country. Also, the inequality in those cities is substantially higher than the Brazilian. We investigate the determinants of this high and persistent inequality for Brasília (Federal District). We use the static decomposition of the generalized entropy indexes and the decomposition by regression with the method of Fields and the Shapley value. We verified that the public sector was the main factor to explain why the inequality was kept high in the capital of Brazil. All the methods reached the same conclusion. While the shrinking differences on the education attainment of the population had an effect of reducing the inequality, the policy of paying better salaries to the public servants had the opposite effect, which preserved the high inequality. This policy induces the migration to Brasília and it has a long run impact on the retirements and pensions benefits, which perpetuates the disparities

A Persistente Desigualdade nas Grandes Cidades Brasileiras: o Caso de Brasília

Using the censuses of 2000 and 2010, we have noticed that the inequality of the household per capita income in the biggest Brazilian cities did not show a trend of reduction, differently from the whole country. Also, the inequality in those cities is substantially higher than the Brazilian. We investigate the determinants of this high and persistent inequality for Brasília (Federal District). We use the static decomposition of the generalized entropy indexes and the decomposition by regression with the method of Fields and the Shapley value. We verified that the public sector was the main factor to explain why the inequality was kept high in the capital of Brazil. All the methods reached the same conclusion. While the shrinking differences on the education attainment of the population had an effect of reducing the inequality, the policy of paying better salaries to the public servants had the opposite effect, which preserved the high inequality. This policy induces the migration to Brasília and it has a long run impact on the retirements and pensions benefits, which perpetuates the disparities

A Persistente Desigualdade nas Grandes Cidades Brasileiras: o Caso de Brasília

Using the censuses of 2000 and 2010, we have noticed that the inequality of the household per capita income in the biggest Brazilian cities did not show a trend of reduction, differently from the whole country. Also, the inequality in those cities is substantially higher than the Brazilian. We investigate the determinants of this high and persistent inequality for Brasília (Federal District). We use the static decomposition of the generalized entropy indexes and the decomposition by regression with the method of Fields and the Shapley value. We verified that the public sector was the main factor to explain why the inequality was kept high in the capital of Brazil. All the methods reached the same conclusion. While the shrinking differences on the education attainment of the population had an effect of reducing the inequality, the policy of paying better salaries to the public servants had the opposite effect, which preserved the high inequality. This policy induces the migration to Brasília and it has a long run impact on the retirements and pensions benefits, which perpetuates the disparities

New drugs from traditional medicines: pharmacological evaluation of plant extracts from Chapada Diamantina (Brazil)

Plants are rich sources of medicines and Brazil is among the most biodiverse nations in the world.info:eu-repo/semantics/publishedVersio

Sage Tea Drinking Improves Lipid Profile and Antioxidant Defences in Humans

Salvia officinalis (common sage) is a plant with antidiabetic properties. A pilot trial (non-randomized crossover trial) with six healthy female volunteers (aged 40–50) was designed to evaluate the beneficial properties of sage tea consumption on blood glucose regulation, lipid profile and transaminase activity in humans. Effects of sage consumption on erythrocytes’ SOD and CAT activities and on Hsp70 expression in lymphocytes were also evaluated. Four weeks sage tea treatment had no effects on plasma glucose. An improvement in lipid profile was observed with lower plasma LDL cholesterol and total cholesterol levels as well as higher plasma HDL cholesterol levels during and two weeks after treatment. Sage tea also increased lymphocyte Hsp70 expression and erythrocyte SOD and CAT activities. No hepatotoxic effects or other adverse effects were observed

Biocompatibility of a self-assembled glycol chitosan nanogel

The research of chitosan-based nanogel for biomedical applications has grown exponentially in the last years; however, its biocompatibility is still insufficiently reported. Hence, the present work provides a thorough study of the biocompatibility of a glycol chitosan (GC) nanogel. The obtained results showed that GC nanogel induced slight decrease on metabolic activity of RAW, 3T3 and HMEC cell cultures, although no effect on cell membrane integrity was verified. The nanogel does not promote cell death by apoptosis and/or necrosis, exception made for the HMEC cell line challenged with the higher GC nanogel concentration. Cell cycle arrest on G1 phase was observed only in the case of RAW cells. Remarkably, the nanogel is poorly internalized by bone marrow derived macrophages and does not trigger the activation of the complement system. GC nanogel blood compatibility was confirmed through haemolysis and whole blood clotting time assays. Overall, the results demonstrated the safety of the use of the GC nanogel as drug delivery system.Paula Pereira thanks FCT, the Ph.D. grant ref SFRH/BD/64977/2009. This work was also supported by a grant from the Spanish Ministry of Economy and Competitivity (SAF2011-30337-C02-02). We also acknowledge the European Union Seventh Framework Programme [FP7/REGPOT-2012-2013.1] under grant agreement BIOCAPS-316265. MP acknowledges fellowship from Spanish Ministry of Education (FPU predoctoral grant program)

Quercetin enhances 5-fluorouracil-induced apoptosis in MSI colorectal cancer cells through p53 modulation

Purpose: Colorectal tumors (CRC) with microsatellite instability (MSI) show resistance to chemotherapy with 5-fluorouracil (5-FU), the most widely used pharmacological drug for CRC treatment. The aims of this study were to test the ability of quercetin (Q) and luteolin (L) to increase sensitivity of MSI CRC cells to 5-FU and characterize the dependence of the effects on cells´ p53 status. Methods: Two MSI human CRC derived cell lines were used, CO115 wild-type (wt) for p53 and HCT15 that harbors a p53 mutation. Apoptosis induction in these cells by 5-FU, Q and L alone and in combinations were evaluated by TUNEL and western. The dependence on p53 of the effects was confirmed by small interference RNA (siRNA) in CO115 cells and in MSI HCT116 wt and p53 knockout cells. Results: CO115 p53-wt cells are more sensitive to 5-FU than the p53 mutated HCT15. The combination treatment of 5-FU with L and Q increased apoptosis with a significant effect for Q in CO115. Both flavonoids increased p53 expression in both cell lines, an effect particularly remarkable for Q. The significant apoptotic enhancement in CO115 incubated with Q plus 5-FU involved the activation of the apoptotic mitochondrial pathway. Importantly, knockdown of p53 by siRNA in CO115 cells and p53 knockout in HCT116 cells totally abrogated apoptosis induction, demonstrating the dependence of the effect on p53 modulation by Q. Conclusion: This study suggests the potential applicability of these phytochemicals for enhancement 5-FU efficiency in MSI CRC therapy, especially Q in p53 wt tumors.CPRX was supported by the Foundation for Science and Technology (FCT), Portugal, through the grant SFRH/BD/27524/2006 and the work was supported by the FCT research grant PTDC/AGR-AAM/70418/2006

Anticancer effects of lactoferrin: underlying mechanisms and future trends in cancer therapy

Lactoferrin has been widely studied over the last 70 years, and its role in diverse biological functions is now well known and generally accepted by the scientific community. Usually, alterations of the lactoferrin gene in cells are associated with an increased incidence of cancer. Several studies suggest that exogenous treatment with lactoferrin and its derivatives can efficiently inhibit the growth of tumors and reduce susceptibility to cancer. None of these studies, however, reported a consistent outcome with regard to the mechanisms underlying the anticancer effects of lactoferrin. In this review, the association of lactoferrin with cancer is thoroughly discussed, from lactoferrin gene expression to the potential use of lactoferrin in cancer therapy. Lactoferrin cytotoxicity against several cancers is reported to occur in distinct ways under different conditions, namely by cell membrane disruption, apoptosis induction, cell cycle arrest, and cell immunoreaction. Based on these mechanisms, new strategies to improve the anticancer effects of the lactoferrin protein and/or its derivatives are proposed. The potential for lactoferrin in the field of cancer research (including as a chemotherapeutic agent in cancer therapy) is also discussed.Funding. Financial support was received from the Erasmus Mundus External Cooperation Window (Y), the Strategic Project PEst-OE/EQB/LA0023/2013, and the Fundacao para a Ciencia e a Tecnologia (project reference RECI/BBB-EBI/0179/2012; project no. FCOMP-01-0124-FEDER-027462)

Heat Stress and Hormetin-Induced Hormesis in Human Cells: Effects on Aging, Wound Healing, Angiogenesis, and Differentiation

Accumulation of molecular damage and increased molecular heterogeneity are hallmarks of cellular aging. Mild stress-induced hormesis can be an effective way for reducing the accumulation of molecular damage, and thus slowing down aging from within. We have shown that repeated mild heat stress (RMHS) has anti-aging effects on growth and various other cellular and biochemical characteristics of normal human skin fibroblasts and keratinocytes undergoing aging in vitro. RMHS given to human cells increased the basal levels of various chaperones, reduced the accumulation of damaged proteins, stimulated proteasomal activities, increased the cellular resistance to other stresses, enhanced the levels of various antioxidant enzymes, enhanced the activity and amounts of sodium-potassium pump, and increased the phosphorylation-mediated activities of various stress kinases. We have now observed novel hormetic effects of mild heat stress on improving the wound healing capacity of skin fibroblasts and on enhancing the angiogenic ability of endothelial cells. We have also tested potential hormetins, such as curcumin and rosmarinic acid in bringing about their beneficial effects in human cells by inducing stress response pathways involving heat shock proteins and hemeoxygenase HO-1. These data further support the view that mild stress-induced hormesis can be applied for the modulation, intervention and prevention of aging and age-related impairments