Carlos Mayo

Conocí a Carlos Mayo cuando ingresó a nuestra Facultad de Humanidades y Ciencias de la Educación de la Universidad Nacional de La Plata para iniciar su carrera en el Profesorado de Historia. Conocerlo significaba inicialmente reconocer sus cualidades como persona, apreciar su simpatía y a la vez su corrección y gusto por las formalidades, sin poder ignorar sus comentarios rápidos e incisivos que movían a la risa de todos. Se destacó ya entonces como alumno y posteriormente demostró cualidades especiales como investigador y como docente, que lo condujeron a desempeñarse, muy joven aún, en cargos de responsabilidad. (Párrafo extraído del texto a modo de resumen)Facultad de Humanidades y Ciencias de la Educació

Representación de la república y la patria en la prensa porteña: variaciones en los tipos iconográficos

Esta presentación forma parte del proyecto denominado La imagen impresa en la prensa escrita en Buenos Aires: 1821-1898. Circulación y recepción para la construcción de una cultura visual en el Río de la Plata y se halla inserto dentro del Plan de Incentivos de la Facultad de Bellas Artes, UNLP. Este trabajo tiene como objetivo el análisis de la imagen impresa sobre un motivo iconográfico en particular: la representación visual de la patria, de la libertad y la república en dos medios de prensa que corresponden a diferentes momentos socio históricos. Es necesario subrayar que los periódicos elegidos como fuentes documentales de la representación visual de la patria a estudiar en este trabajo, se editaron en situaciones políticas sociales muy dispares.Mesa 1Facultad de Bellas Arte

Representación de la república y la patria en la prensa porteña: variaciones en los tipos iconográficos

Esta presentación forma parte del proyecto denominado La imagen impresa en la prensa escrita en Buenos Aires: 1821-1898. Circulación y recepción para la construcción de una cultura visual en el Río de la Plata y se halla inserto dentro del Plan de Incentivos de la Facultad de Bellas Artes, UNLP. Este trabajo tiene como objetivo el análisis de la imagen impresa sobre un motivo iconográfico en particular: la representación visual de la patria, de la libertad y la república en dos medios de prensa que corresponden a diferentes momentos socio históricos. Es necesario subrayar que los periódicos elegidos como fuentes documentales de la representación visual de la patria a estudiar en este trabajo, se editaron en situaciones políticas sociales muy dispares.Mesa 1Facultad de Bellas Arte

Representación de la república y la patria en la prensa porteña: variaciones en los tipos iconográficos

Esta presentación forma parte del proyecto denominado La imagen impresa en la prensa escrita en Buenos Aires: 1821-1898. Circulación y recepción para la construcción de una cultura visual en el Río de la Plata y se halla inserto dentro del Plan de Incentivos de la Facultad de Bellas Artes, UNLP. Este trabajo tiene como objetivo el análisis de la imagen impresa sobre un motivo iconográfico en particular: la representación visual de la patria, de la libertad y la república en dos medios de prensa que corresponden a diferentes momentos socio históricos. Es necesario subrayar que los periódicos elegidos como fuentes documentales de la representación visual de la patria a estudiar en este trabajo, se editaron en situaciones políticas sociales muy dispares.Mesa 1Facultad de Bellas Arte

Molecular Mechanisms Generating and Stabilizing Terminal 22q13 Deletions in 44 Subjects with Phelan/McDermid Syndrome

In this study, we used deletions at 22q13, which represent a substantial source of human pathology (Phelan/McDermid syndrome), as a model for investigating the molecular mechanisms of terminal deletions that are currently poorly understood. We characterized at the molecular level the genomic rearrangement in 44 unrelated patients with 22q13 monosomy resulting from simple terminal deletions (72%), ring chromosomes (14%), and unbalanced translocations (7%). We also discovered interstitial deletions between 17–74 kb in 9% of the patients. Haploinsufficiency of the SHANK3 gene, confirmed in all rearrangements, is very likely the cause of the major neurological features associated with PMS. SHANK3 mutations can also result in language and/or social interaction disabilities. We determined the breakpoint junctions in 29 cases, providing a realistic snapshot of the variety of mechanisms driving non-recurrent deletion and repair at chromosome ends. De novo telomere synthesis and telomere capture are used to repair terminal deletions; non-homologous end-joining or microhomology-mediated break-induced replication is probably involved in ring 22 formation and translocations; non-homologous end-joining and fork stalling and template switching prevail in cases with interstitial 22q13.3. For the first time, we also demonstrated that distinct stabilizing events of the same terminal deletion can occur in different early embryonic cells, proving that terminal deletions can be repaired by multistep healing events and supporting the recent hypothesis that rare pathogenic germline rearrangements may have mitotic origin. Finally, the progressive clinical deterioration observed throughout the longitudinal medical history of three subjects over forty years supports the hypothesis of a role for SHANK3 haploinsufficiency in neurological deterioration, in addition to its involvement in the neurobehavioral phenotype of PMS

MicroRNA Modulation during Orthodontic Tooth Movement: A Promising Strategy for Novel Diagnostic and Personalized Therapeutic Interventions

The Orthodontic Tooth Movement (OTM) is allowed through a mediated cell/tissue mechanism performed by applying a force or a pair of forces on the dental elements, and the tooth movement is a fundamental requirement during any orthodontic treatment. In this regard, it has been widely shown that each orthodontic treatment has a minimum duration required concerning numerous factors (age, patient compliance, type of technique used, etc.). In this regard, the aim of the following revision of the literature is to give readers a global vision of principal microRNAs (miRNAs) that are most frequently associated with OTM and their possible roles. Previously published studies of the last 15 years have been considered in the PubMed search using “OTM” and “miRNA” keywords for the present review article. In vitro and in vivo studies and clinical trials were mainly explored. Correlation between OTM and modulation of several miRNAs acting through post-transcriptional regulation on target genes was observed in the majority of previous studied. The expression analysis of miRNAs in biological samples, such as gingival crevicular fluid (GCF), can be considered a useful tool for novel diagnostic and/or prognostic approaches and for new personalized orthodontic treatments able to achieve a better clinical response rate. Although only a few studies have been published, the data obtained until now encourage further investigation of the role of miRNA modulation during orthodontic treatment. The aim of this study is to update the insights into the role and impact of principal micro-RNAs (miRNAs) that are most frequently associated during OTM

Er:Y₂O₃ and Nd:Y₂O₃ Nanoparticles: Synthesis, Pegylation, Characterization and Study of Their Luminescence Properties

Lanthanide-doped yttrium oxide nanoparticles can display selective upconversion properties, rendering them invaluable in the field of nanomedicine for both sensing and diagnostics. Different syntheses of Er:Y2O3 and Nd:Y2O3 nanoparticles (NPs) were studied and optimized to obtain small particles of regular shape and good crystallinity. The morphological and compositional characterizations of the nanoparticles were obtained with different techniques and showed that both Er:Y2O3 and Nd:Y2O3 NPs were well dispersed, with dimensions of the order of a few tens of nanometers. The photoluminescence and cathodoluminescence measurements showed that both Er:Y2O3 and Nd:Y2O3 NPs had good emission as well as upconversion. The nanophosphors were functionalized by a pegylation procedure to suppress unwanted reactions of the NPs with other biological components, making the NP systems biocompatible and the NPs soluble in water and well dispersed. The pegylated core/shell nanoparticles showed the same morphological and optical characteristics as the core, promoting their strategic role as photoactive material for theragnostics and biosensing