Insuficiencia cardiaca: prevalencia, registro y valor diagnóstico del péptido cerebral natriurético

Tesis doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de lectura: 19 de Octubre de 2012

Experimental color encryption in a joint transform correlator architecture

We present an experimental color image encryption by using a photorefractive crystal and a joint transform correlator (JTC) architecture. We achieve the color storing by changing the illumination wavelength. One JTC aperture has the input image information corresponding to a determined color channel bonded to a random phase mask (object aperture), and the other JTC aperture contains the key code mask. The joint power spectrum is stored in a photorefractive crystal. Each color data is stored as a modulation of birefringence in this photosensitive medium. The adequate wavelength change produces a corresponding power spectrum modification that avoids image encryption cross talk in the read out step. An analysis in terms of the sensitivity of the photorefractive silenite crystal for different recording wavelengths is carried out. It should be highlighted that the multiplexed power spectrum shows neither the multiplexing operation nor the amount of stored information increasing the system security. We present experimental results that support our approach.Facultad de IngenieríaFacultad de Ciencias Exacta

Experimental color encryption in a joint transform correlator architecture

We present an experimental color image encryption by using a photorefractive crystal and a joint transform correlator (JTC) architecture. We achieve the color storing by changing the illumination wavelength. One JTC aperture has the input image information corresponding to a determined color channel bonded to a random phase mask (object aperture), and the other JTC aperture contains the key code mask. The joint power spectrum is stored in a photorefractive crystal. Each color data is stored as a modulation of birefringence in this photosensitive medium. The adequate wavelength change produces a corresponding power spectrum modification that avoids image encryption cross talk in the read out step. An analysis in terms of the sensitivity of the photorefractive silenite crystal for different recording wavelengths is carried out. It should be highlighted that the multiplexed power spectrum shows neither the multiplexing operation nor the amount of stored information increasing the system security. We present experimental results that support our approach.Facultad de IngenieríaFacultad de Ciencias Exacta

Comprehensive analysis of GABAA-A1R developmental alterations in Rett Syndrome: setting the focus for therapeutic targets in the time frame of the disease

Rett syndrome, a serious neurodevelopmental disorder, has been associated with an altered expression of different synaptic-related proteins and aberrant glutamatergic and γ-aminobutyric acid (GABA)ergic neurotransmission. Despite its severity, it lacks a therapeutic option. Through this work we aimed to define the relationship between MeCP2 and GABAA.-A1 receptor expression, emphasizing the time dependence of such relationship. For this, we analyzed the expression of the ionotropic receptor subunit in different MeCP2 gene-dosage and developmental conditions, in cells lines, and in primary cultured neurons, as well as in different developmental stages of a Rett mouse model. Further, RNAseq and systems biology analysis was performed from post-mortem brain biopsies of Rett patients. We observed that the modulation of the MeCP2 expression in cellular models (both Neuro2a (N2A) cells and primary neuronal cultures) revealed a MeCP2 positive effect on the GABAA.-A1 receptor subunit expression, which did not occur in other proteins such as KCC2 (Potassium-chloride channel, member 5). In the Mecp2+/- mouse brain, both the KCC2 and GABA subunits expression were developmentally regulated, with a decreased expression during the pre-symptomatic stage, while the expression was variable in the adult symptomatic mice. Finally, the expression of the gamma-aminobutyric acid (GABA) receptor-related synaptic proteins from the postmortem brain biopsies of two Rett patients was evaluated, specifically revealing the GABA A1R subunit overexpression. The identification of the molecular changes along with the Rett syndrome prodromic stages strongly endorses the importance of time frame when addressing this disease, supporting the need for a neurotransmission-targeted early therapeutic intervention

Life after the squares: reflections on the consequences of the Occupy movements

This is a roundtable with reflections on Tahrir Square, Egypt; Syntagma Square, Greece; Rossio Square, Portugal; 15-M Puerta del Sol, Spain; Gezi Park, Turkey; and Occupy Wall Street, USA. Five years on from the birth of the movements of the streets and the squares in Tahrir Square, what has changed? This roundtable brings movement participants together in reflection on themes such as legacies, key practices and knowledge, cultural creation, and links to institutional politics. Contributors share their understanding of the situations in Egypt, Portugal, Spain, and Turkey and we present their reflections in full and virtually unedited. Note: for reasons of space this print version of the roundtable excludes the contributions from OWS (Anonymous) and a shortened version of the contribution from Wiam El-Tamami. The full version is available as an open access download at the Social Movement Studies website (Available to download at the Supplemental Files section attached to this article at http://www.tandfonline.com/toc/csms20/16/1). The full version is also available in Spanish with additional content at Alexia (http://revistaalexia.es/)

Peroxisome proliferator activated receptor gamma 2 modulates late pregnancy homeostatic metabolic adaptations.

Pregnancy requires the adaptation of maternal energy metabolism including expansion and functional modifications of adipose tissue. Insulin resistance (IR), predominantly during late gestation, is a physiological metabolic adaptation that serves to support the metabolic demands of fetal growth. The molecular mechanisms underlying these adaptations are not fully understood and may contribute to gestational diabetes mellitus. Peroxisome proliferator-activated receptor gamma (PPARγ) controls adipogenesis, glucose and lipid metabolism and insulin sensitivity. The PPARγ2 isoform is mainly expressed in adipocytes and is thus likely to contribute to adipose tissue adaptation during late pregnancy. In the present study, we investigated the contribution of PPARγ2 to the metabolic adaptations occurring during the late phase of pregnancy in the context of IR. Using a model of late pregnancy in PPARγ2 knockout (KO) mice, we found that deletion of PPARγ2 exacerbated IR in association with lower serum adiponectin levels, increased body weight and enhanced lipid accumulation in liver. Lack of PPARγ2 provoked changes in the distribution of fat mass and preferentially prevented the expansion of the perigonadal depot while at the same time exacerbating inflammation. PPARγ2KO pregnant mice presented adipose tissue depot-dependent decreased expression of genes involved in lipid metabolism. Collectively, these data indicate that PPARγ2 is essential to promote healthy adipose tissue expansion and immune and metabolic functionality during pregnancy, contributing to the physiological adaptations that lead gestation to term.This work was supported by grants from the Spanish Ministry of Economy and Competitiveness: BFU2012-33594 and BFU2013-47384-R to GMG; SAF2015- 64287-R to M. Ricote; and SAF2014-56671-R to MPR; predoctoral fellowship BES-2010- 038107 to YV; and grants S2010/BMD-2423 from the Community of Madrid to MPR and GMG. The authors thank Saverio Cinti for his helpful comments with histological samples, Antonio Vidal-Puig for his help in discussion and Lucia Torres for technical assistance.S

Experimental color encryption in a joint transform correlator architecture

We present an experimental color image encryption by using a photorefractive crystal and a joint transform correlator (JTC) architecture. We achieve the color storing by changing the illumination wavelength. One JTC aperture has the input image information corresponding to a determined color channel bonded to a random phase mask (object aperture), and the other JTC aperture contains the key code mask. The joint power spectrum is stored in a photorefractive crystal. Each color data is stored as a modulation of birefringence in this photosensitive medium. The adequate wavelength change produces a corresponding power spectrum modification that avoids image encryption cross talk in the read out step. An analysis in terms of the sensitivity of the photorefractive silenite crystal for different recording wavelengths is carried out. It should be highlighted that the multiplexed power spectrum shows neither the multiplexing operation nor the amount of stored information increasing the system security. We present experimental results that support our approach.Facultad de IngenieríaFacultad de Ciencias Exacta

Multiplexado en color para esquemas ópticos de encriptación

Es de interés almacenar múltiples datos encriptados en un único medio de registro. Para dicho fin proponemos un esquema multiplexado en longitud de onda, libre de solapamiento y que por lo tanto hace que las diversas imágenes almacenadas en un único paquete puedan ser recuperadas individualmente, aun empleando la misma máscara encriptadora. Se realizará un estudio detallado de los mecanismos que permitan eliminar el solapamiento de la información en el plano de recuperación. Para ello, se analizará una arquitectura óptica para la implementación del manejo seguro de múltiples imágenes por medio de canales de color. Las imágenes encriptadas y multiplexadas están constituidas por la suma de diagramas de speckle indistinguibles, por lo tanto no es posible determinar ni la cantidad ni la naturaleza de las imágenes almacenadas lo que establece el grado de seguridad de la información codificada.Publicado en Terceras Jornadas de Investigación, Transferencia y Extensión. La Plata : Universidad Nacional de La Plata, 2015.Facultad de Ingenierí

Multiplexado en color para esquemas ópticos de encriptación

Es de interés almacenar múltiples datos encriptados en un único medio de registro. Para dicho fin proponemos un esquema multiplexado en longitud de onda, libre de solapamiento y que por lo tanto hace que las diversas imágenes almacenadas en un único paquete puedan ser recuperadas individualmente, aun empleando la misma máscara encriptadora. Se realizará un estudio detallado de los mecanismos que permitan eliminar el solapamiento de la información en el plano de recuperación. Para ello, se analizará una arquitectura óptica para la implementación del manejo seguro de múltiples imágenes por medio de canales de color. Las imágenes encriptadas y multiplexadas están constituidas por la suma de diagramas de speckle indistinguibles, por lo tanto no es posible determinar ni la cantidad ni la naturaleza de las imágenes almacenadas lo que establece el grado de seguridad de la información codificada.Publicado en Terceras Jornadas de Investigación, Transferencia y Extensión. La Plata : Universidad Nacional de La Plata, 2015.Facultad de Ingenierí

Multiplexado en color para esquemas ópticos de encriptación

Es de interés almacenar múltiples datos encriptados en un único medio de registro. Para dicho fin proponemos un esquema multiplexado en longitud de onda, libre de solapamiento y que por lo tanto hace que las diversas imágenes almacenadas en un único paquete puedan ser recuperadas individualmente, aun empleando la misma máscara encriptadora. Se realizará un estudio detallado de los mecanismos que permitan eliminar el solapamiento de la información en el plano de recuperación. Para ello, se analizará una arquitectura óptica para la implementación del manejo seguro de múltiples imágenes por medio de canales de color. Las imágenes encriptadas y multiplexadas están constituidas por la suma de diagramas de speckle indistinguibles, por lo tanto no es posible determinar ni la cantidad ni la naturaleza de las imágenes almacenadas lo que establece el grado de seguridad de la información codificada.Publicado en Terceras Jornadas de Investigación, Transferencia y Extensión. La Plata : Universidad Nacional de La Plata, 2015.Facultad de Ingenierí