Risk factors for alloimmunisation in the general patient population

For hospitals providing services to regional populations, difficulties are associated with transferred patients with poorly communicated medical history and a risk of alloimmunisation. Identification of patients at risk would assist in treatment planning. A retrospective study of alloimmunised patients was undertaken, comparing the demographics and diagnoses of this population with a control patient population. A preponderance of diagnoses of Sepsis, Haematological Malignancy, GIT Bleeds and Renal Failure was demonstrated in the alloimmunised population. Consistent with prior studies, RhD negative patients and female patients were over-represented in the study group, which was also on average significantly older

Outcome selection and role of patient reported outcomes in contemporary cardiovascular trials: systematic review

Objectives To systematically assess the type of outcomes selected and the prevalence of patient reported outcomes in contemporary cardiovascular trials and to quantify any misuse or underuse of patient reported outcomes using a specially developed tool that would allow estimation of the relevance of such outcomes to clinical decision making

The structure of epitaxial V2O3 films and their surfaces : a medium energy ion scattering study

Medium energy ion scattering, using 100 keV H+ incident ions, has been used to investigate the growth of epitaxial films, up to thicknesses of ~200 Å, of V2O3 on both Pd(111) and Au(111). Scattered-ion energy spectra provide a measure of the average film thickness and the variations in this thickness, and show that, with suitable annealing, the crystalline quality is good. Plots of the scattering yield as a function of scattering angle, so-called blocking curves, have been measured for two different incidence directions and have been used to determine the surface structure. Specifically, scattering simulations for a range of different model structures show poor agreement with experiment for half-metal (….V’O3V) and vanadyl (….V’O3V=O) terminations, with and without surface interlayer relaxations. However, good agreement with experiment is found for the modified oxygen-termination structure, first proposed by Kresse et al., in which a subsurface V half-metal layer is moved up into the outermost V buckled metal layer to produce a VO2 overlayer on the underlying V2O3, with an associated layer structure of ….O3VV’’V’O3

Outcomes of haematology/oncology patients admitted to intensive care unit at The Canberra Hospital

BACKGROUND: Outcomes for haematology/oncology patients have improved; however, determining their suitability for intensive care unit (ICU) admission remains challenging and controversial. AIM: Examine outcomes of patients admitted to an Australian tertiary hospital ICU and explore potential prognostic factors. METHODS: A retrospective review of patients with haematological and solid tumour malignancies non-electively admitted to The Canberra Hospital (TCH) ICU, between January 2008 and December 2012. Patient demographics, cancer details, reasons for ICU admission and Acute Physiologic and Chronic Health Evaluation (APACHE) II scores were collected, and survival rates calculated and correlated with potential prognostic factors. RESULTS Of 205 patients, 113 (55%) had haematological malignancies, and 92 (45%) had solid tumours: 58% male and mean age 60.3 years (standard deviation (SD) 13.4). Eighty-two per cent of solid tumour patients had metastatic disease and 55% received palliative chemotherapy. Primary reasons for ICU admission included sepsis (59%), respiratory distress (37%) and hypotension/shock (18%). Mean APACHE II score was 20.1(SD 0.55); mean length of stay in ICU, 4 days (SD 5.2); ICU survival was 76% with 62% and 41% alive at 30 days and 6 months respectively. Overall 1-year survival was 36%. High APACHE II scores and ≥2 organs failing were significant risk factors for 30-day mortality. CONCLUSION: Short-term outcomes were similar to contemporary studies from a general tertiary hospital setting and better than historical data. Sixty-two per cent of patients were alive 30 days post-ICU admission, with a significant minority alive at 12 months, confirming some patients achieved worthwhile outcomes. Further research is needed to ensure appropriate patient selection and to explore quality of life post ICU

Structural role of the tyrosine residues of cytochrome c

The tertiary structures of horse, tuna, Neurospora crassa, horse [Hse65,Leu67]- and horse [Hse65,Leu74]-cytochromes c were studied with high-resolution 1H n.m.r. spectroscopy. The amino acid sequences of these proteins differ at position 46, which is occupied by phenylalanine in the horse proteins but by tyrosine in the remaining two, and at positions 67, 74 and 97, which are all occupied by tyrosine residues in horse and tuna cytochrome c but in the other proteins are substituted by phenylalanine or leucine, though there is only one such substitution per protein. The various aromatic-amino-acid substitutions do not seriously affect the protein structure

Customizable Operating Systems

A customizable operating system is one that can adapt to improve its functionality or performance. The need for customizable and application-specific operating systems has been recognized for many years, but they have yet to appear in the commercial market. This paper explores the notion of operating system customizability and examines the limits of existing approaches. The paper begins by surveying system structuring approaches for the safe and efficient execution of customizable operating systems. Then it discusses the burden that existing approaches impose on application software, and explores techniques for reducing this burden. Finally, support for customizability in the Synthetix project is described and illustrated through two examples: a dynamically specialized file system read call, and an adaptive Internet-based MPEG video player

Settlement of axially loaded pile groups in inhomogeneous soil

Tema rada su gubici učinskog MOSFET-a. Cilj rada je izračunavanje vremenskog tijeka gubitaka u sklopovima energetske elektronike s definiranom točnošću. Svrha rada je upotreba rezultata izračunavanja u proračunu strujne opteretivosti učinskog MOSFET-a, odnosno u postupku električkog i toplinskog projektiranja pretvaračkih sklopova.Power MOSFET losses are the subject of this dissertation. It's aim is to calculate the time course of losses in power electronic circuits with a defined accuracy. The purpose of this work is to enable the utilization of calculation of current capability of the power MOSFET, i.e. in the procedure of electric and thermal designs of converter circuits

Constraining the Origin and Age of the Thermal and Cold Water in the Lake Natron Basin, Northern Tanzania

Springs on the eastern and western shores of Lake Natron Basin (LNB), located within the eastern branch of the East Africa Rift System (EARS) in Northern Tanzania had a discharge temperature that ranged between 34.0 °C and 51.2 °C, while the pH varied from 8.0 to 10.7. The electrical conductivity (EC) ranged between 5,007 µS/cm and 49,200 µS/cm. Cold waters had a temperature of 31.9 °C to 32.5 °C, while the pH ranged between 8.0 and 8.3, and the EC ranged between 1,401 µS/cm and 3,806 µS/cm. The stable isotope composition varied between -2.4 ‰ and -5.3 ‰ for δ18O, and -15.5 ‰ to -29.3 ‰ for δ2H. The isotopic composition of thermal and cold water of LNB indicates a significant contribution of meteoric water in the recharge of the hydrothermal system. However, thermal water is affected by evaporation, water-rock interaction, carbon dioxide (CO2) exchange and condensation processes. Tritium analysis indicated that the spring water in the LNB hydrothermal system has a residence time of more than 50 years. Keywords:    thermal water; Lake Natron Basin; stable isotopes; springs. &nbsp