Free Space Optical Link Utilizing a Modulated Retro-Reflector Intended for Planetary Duplex Communication Links Between an Orbiter and Surface Unit

Presented are simulation and experimental results that provide duplex optical-free space communication links with minimal power and pointing requirements by using a modulated retro-reflector (MRR) for planetary communications. The design is the MRR resides on the surface of a planet or moon, where energy is scarce, while the source of the communication laser resides on an orbiter to achieve satellite-to-ground communications. Also, a simulated scenario using the Mars Reconnaissance Orbiter (MRO) is provided for real world potential results. The information sent through this communication path can range from raw scientific data to multimedia files such as videos and pictures. Bidirectional communications is established with the MRR by using a nested pulse position modulation (PPM) structure. This modulation scheme is then evaluated for its validity in a proof-of-concept experiment. Initial results indicate a promising return-link performance of at least 300 kbps in the nested arrangement

In flight performance and first results of FREGATE

The gamma-ray detector of HETE-2, called FREGATE, has been designed to detect gamma-ray bursts in the energy range [6-400] keV. Its main task is to alert the other instruments of the occurrence of a gamma-ray burst (GRB) and to provide the spectral coverage of the GRB prompt emission in hard X-rays and soft gamma-rays. FREGATE was switched on on October 16, 2000, one week after the successful launch of HETE-2, and has been continuously working since then. We describe here the main characteristics of the instrument, its in-flight performance and we briefly discuss the first GRB observations.Comment: Invited lecture at the Woods Hole 2001 GRB Conference, 8 pages, 15 figure

Time-resolved X-ray spectral modeling of an intermediate burst from SGR1900+14 observed by HETE-2/FREGATE and WXM

We present a detailed analysis of a 3.5 s long burst from SGR 1900+14 that occurred on 2001 July 2. The 2-150 keV time-integrated energy spectrum is well described by the sum of two blackbodies whose temperatures are approximately 4.3 and 9.8 keV. The time-resolved energy spectra are similarly well fitted by the sum of two blackbodies. The higher temperature blackbody evolves with time in a manner consistent with a shrinking emitting surface. The interpretation of these results in the context of the magnetar model suggests that the two-blackbody fit is an approximation of an absorbed, multitemperature spectrum expected on theoretical grounds rather than a physical description of the emission. If this is indeed the case, our data provide further evidence for a strong magnetic field and indicate that the entire neutron star was radiating during most of the burst duration

Phase I trial of intravesical Suramin in recurrent superficial transitional cell bladder carcinoma

Suramin is an antitrypanosomal agent with antineoplastic activity, but with serious systemic side effects. We administered Suramin intravesically to determine a concentration with low toxicity but with evidence of a pharmacodynamic effect, to recommend a dose level for phase II trials. This was an open-labelled, nonrandomised dose-escalation phase I study. In all, 12 patients with a history of recurrent superficial bladder cancer were grouped into four dose levels (10–150 mg ml−1 in 60 ml saline). Six catheter instillations at weekly intervals were used. Cystoscopy and biopsy were performed before and 3 months after the start of treatment. Suramin was assayed using high-performance liquid chromatography, vascular endothelial growth factor (VEGF) using ELISA (enzyme-linked immunosorbent assay), and urinary protein profile using surface-enhanced laser desorption ionisation mass spectroscopy (SELDI). Minimal systemic absorption of Suramin was found at the highest dose of 150 mg ml−1. Urinary VEGF was affected by Suramin at doses above 50 mg ml−1, corresponding to the estimated threshold of saturation of Suramin binding to urine albumin. SELDI showed a specific disappearance of urinary protein peaks during treatment. Intravesical Suramin shows lack of toxicity and low systemic absorption. The results of this phase I trial support expanded clinical trials of efficacy at a dose of 100 mg ml−1 intravesically

Scientific Highlights of the HETE-2 Mission

The HETE-2 mission has been highly productive. It has observed more than 250 GRBs so far. It is currently localizing 25 - 30 GRBs per year, and has localized 43 GRBs to date. Twenty-one of these localizations have led to the detection of X-ray, optical, or radio afterglows, and as of now, 11 of the bursts with afterglows have known redshifts. HETE-2 has confirmed the connection between GRBs and Type Ic supernovae, a singular achievement and certainly one of the scientific highlights of the mission so far. It has provided evidence that the isotropic-equivalent energies and luminosities of GRBs are correlated with redshift, implying that GRBs and their progenitors evolve strongly with redshift. Both of these results have profound implications for the nature of GRB progenitors and for the use of GRBs as a probe of cosmology and the early universe. HETE-2 has placed severe constraints on any X-ray or optical afterglow of a short GRB. It is also solving the mystery of "optically dark' GRBs, and revealing the nature of X-ray flashes.Comment: 10 pages, 9 figures, to appear in proc. "The Restless High-Energy Universe", Royal Tropical Institute, Amsterdam; revised text, added ref

HETE-2 Observation of two gamma-ray bursts at z > 3

GRB 020124 and GRB 030323 constitute half the sample of gamma-ray bursts with a measured redshift greater than 3. This paper presents the temporal and spectral properties of these two gamma-ray bursts detected and localized with HETE-2. While they have nearly identical redshifts (z=3.20 for GRB 020124, and z=3.37 for GRB 030323), these two GRBs span about an order of magnitude in fluence, thus sampling distinct regions of the GRB luminosity function. The properties of these two bursts are compared with those of the bulk of the GRB population detected by HETE-2. We also discuss the energetics of GRB 020124 and GRB 030323 and show that they are compatible with the Epeak - Eiso relation discovered by Amati et al. (2002). Finally, we compute the maximum redshifts at which these bursts could have been detected by HETE-2 and we address various issues connected with the detection and localization of high-z GRBs.Comment: 19 pages, 4 figures, submitted to Ap