Jump-Starting the Internet Revolution: How Structural Conduciveness and Global Connections Help Diffuse the Internet

The growing perception that the Internet is becoming an engine of global economic and social change has inspired both governments and intergovernmental agencies to accelerate the diffusion of the Internet around the globe via multimillion dollar programs and initiatives. Unfortunately, few empirical studies guide these initiatives. The purpose of this research is to investigate the causes that drive Internet capacity, with special emphasis on diffusion theory. Global diffusion of IT requires some degree of structural conduciveness (similarities between developed and developing countries in economic, political, and social structures) as well as contact with developed countries. In our pooled time-series models of 58 developing nations over the 1995-2000 time period, we find that both structural conduciveness (i.e., teledensity, service economies, political openness, and global urban share) and globalization (i.e., aid share, tourist share, foreign investment share, and trade share) shape the distribution and growth of Internet usage

A reverberation-based black hole mass for MCG-06-30-15

We present the results of a reverberation campaign targeting MGC-06-30-15. Spectrophotometric monitoring and broad-band photometric monitoring over the course of 4 months in the spring of 2012 allowed a determination of a time delay in the broad Hβ emission line of τ =5.3 ± 1.8 days in the rest frame of the AGN. Combined with the width of the variable portion of the emission line, we determine a black hole mass of MBH = (1.6 ± 0.4) x 106 M_sun. Both the Hβ time delay and the black hole mass are in good agreement with expectations from the RBLR - L and MBH - σ* relationships for other reverberation-mapped AGNs. The Hβ time delay is also in good agreement with the relationship between H and broad-band near-IR delays, in which the effective BLR size is ∼4-5 times smaller than the inner edge of the dust torus. Additionally, the reverberation-based mass is in good agreement with estimates from the X-ray power spectral density break scaling relationship, and with constraints based on stellar kinematics derived from integral field spectroscopy of the inner ∼ 0.5 kpc of the galaxy.Publisher PDFPeer reviewe

Common Variants at 9p21 and 8q22 Are Associated with Increased Susceptibility to Optic Nerve Degeneration in Glaucoma

Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normal-pressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease. We have performed a meta-analysis of two independent genome-wide association studies for primary open angle glaucoma (POAG) followed by a normal-pressure glaucoma (NPG, defined by intraocular pressure (IOP) less than 22 mmHg) subgroup analysis. The single-nucleotide polymorphisms that showed the most significant associations were tested for association with a second form of glaucoma, exfoliation-syndrome glaucoma. The overall meta-analysis of the GLAUGEN and NEIGHBOR dataset results (3,146 cases and 3,487 controls) identified significant associations between two loci and POAG: the CDKN2BAS region on 9p21 (rs2157719 [G], OR = 0.69 [95%CI 0.63–0.75], p = 1.86×10−18), and the SIX1/SIX6 region on chromosome 14q23 (rs10483727 [A], OR = 1.32 [95%CI 1.21–1.43], p = 3.87×10−11). In sub-group analysis two loci were significantly associated with NPG: 9p21 containing the CDKN2BAS gene (rs2157719 [G], OR = 0.58 [95% CI 0.50–0.67], p = 1.17×10−12) and a probable regulatory region on 8q22 (rs284489 [G], OR = 0.62 [95% CI 0.53–0.72], p = 8.88×10−10). Both NPG loci were also nominally associated with a second type of glaucoma, exfoliation syndrome glaucoma (rs2157719 [G], OR = 0.59 [95% CI 0.41–0.87], p = 0.004 and rs284489 [G], OR = 0.76 [95% CI 0.54–1.06], p = 0.021), suggesting that these loci might contribute more generally to optic nerve degeneration in glaucoma. Because both loci influence transforming growth factor beta (TGF-beta) signaling, we performed a genomic pathway analysis that showed an association between the TGF-beta pathway and NPG (permuted p = 0.009). These results suggest that neuro-protective therapies targeting TGF-beta signaling could be effective for multiple forms of glaucoma

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma

Abstract Optic nerve degeneration caused by glaucoma is a leading cause of blindness worldwide. Patients affected by the normalpressure form of glaucoma are more likely to harbor risk alleles for glaucoma-related optic nerve disease. We have performed a meta-analysis of two independent genome-wide association studies for primary open angle glaucoma (POAG) followed by a normal-pressure glaucoma (NPG, defined by intraocular pressure (IOP) less than 22 mmHg) subgroup analysis. The single-nucleotide polymorphisms that showed the most significant associations were tested for association with a second form of glaucoma, exfoliation-syndrome glaucoma. The overall meta-analysis of the GLAUGEN and NEIGHBOR dataset results (3,146 cases and 3,487 controls) identified significant associations between two loci and POAG: the .06], p = 0.021), suggesting that these loci might contribute more generally to optic nerve degeneration in glaucoma. Because both loci influence transforming growth factor beta (TGF-beta) signaling, we performed a genomic pathway analysis that showed an association between the TGF-beta pathway and NPG (permuted p = 0.009). These results suggest that neuro-protective therapies targeting TGFbeta signaling could be effective for multiple forms of glaucoma

Passing through : negotiating identity, sexuality and movement in Ahmed Imamovic’s Go West

Bosnian director Ahmed Imamović’s 2005 film Go West, situated at the breakout of war in Bosnia and Herzegovina during the disintegration of Yugoslavia, follows an ethnically mixed gay couple as they attempt to escape war and gain entry to Europe. While hiding out in a small village in eastern Bosnia, Milan has his partner Kenan dress as a woman so that they can ‘pass’ as a married heterosexual couple. The notion of ‘passing’ and ‘passing through’ are some of the key themes in the film and will be the focal point of my analysis. My claim is that Go West’s emphasis on a ‘good’ and ‘bad’ Europe lacks an intersectional understanding of power relations and directly influences the scope of (im)possible identities and sexualities that are presented in the film. Moreover, looking at how identity and sexuality are constructed and mediated in the film through the lens of ‘nesting orientalisms’ and ‘Balkanism,’ my aim is to bring to light an ideological duality that is created between the idea of a peaceful, liberated Europe and another Europe that always lags behind the West