A Framework for Assessing the Rationality of Judgments in Carcinogenicity Hazard Identification

Arguing that guidelines for identifying carcinogens now lack a philosophically rigorous framework, the authors present an alternative that draws clear attention to the process of reasoning towards judgments of carcinogenicity

A climatological analysis of heatbursts in Oklahoma (1994–2009)

Heatbursts are characterized by a sudden and highly localized increase in air temperature, a simultaneous decrease in relative humidity and dewpoint temperature, and strong gusty winds, typically associated with decaying thunderstorms. The small spatial extent and short duration of most heatbursts makes detailed study of these events difficult using the standard federal observation network (e.g. hourly observations) established in most countries. Thus, many discussions of heatbursts note that they are ‘rare’ phenomena. However, observations from the Oklahoma Mesonet indicate that although heatbursts are meso-alpha scale phenomena, they are not rare. Using multi-criteria analysis, 207 heatburst events of various magnitudes, areal coverage and duration were identified between 1994 and 2009 across Oklahoma. Significantly more heatbursts were detected in the western two-thirds of the state as compared to the eastern third. Heatbursts were primarily nocturnal events, with 70% of heatburst events initiated between 0000 and 0800 UTC (i.e. between 6 p.m. and 2 a.m. Central Standard Time). With 62 of the 207 events, June was the most active month for heatbursts. At the other extreme, no heatbursts were detected during February and November, and only one was observed during January and December. Almost all of the heatbursts occurred underneath or adjacent to weak radar echoes at the time of the event. Four basic radar patterns were associated with the events: (1) radar echoes associated with rapidly weakening convection, (2) weak reflectivity not produced by or associated with deep moist convection, (3) weak radar echoes to the rear of a dissipating mesoscale convective system (MCS) and (4) weak reflectivity along the periphery of intense convection that did not appear to be weakening

Star Formation, Radio Sources, Cooling X-ray Gas, and Galaxy Interactions in the Brightest Cluster Galaxy in 2A0335+096

We present deep emission-line imaging taken with the SOAR Optical Imaging Camera of the brightest cluster galaxy (BCG) in the nearby (z=0.035) X-ray cluster 2A0335+096. We analyze long-slit optical spectroscopy, archival VLA, Chandra X-ray, and XMM UV data. 2A0335+096 is a bright, cool-core X-ray cluster, once known as a cooling flow. Within the highly disturbed core revealed by Chandra X-ray observations, 2A0335+096 hosts a highly structured optical emission-line system. The redshift of the companion is within 100 km/s of the BCG and has certainly interacted with the BCG, and is likely bound to it. The comparison of optical and radio images shows curved filaments in H-alpha emission surrounding the resolved radio source. The velocity structure of the emission-line bar between the BCG nucleus and the companion galaxy provides strong evidence for an interaction between the two in the last ~50 Myrs. The age of the radio source is similar to the interaction time, so this interaction may have provoked an episode of radio activity. We estimate a star formation rate of >7 solar mass/yr based on the Halpha and archival UV data, a rate similar to, but somewhat lower than, the revised X-ray cooling rate of 10-30 solar masses/year estimated from XMM spectra by Peterson & workers. The Halpha nebula is limited to a region of high X-ray surface brightness and cool X-ray temperature. The detailed structures of H-alpha and X-ray gas differ. The peak of the X-ray emission is not the peak of H-alpha emission, nor does it lie in the BCG. The estimated age of the radio lobes and their interaction with the optical emission-line gas, the estimated timescale for depletion and accumulation of cold gas, and the dynamical time in the system are all similar, suggesting a common trigger mechanism.Comment: Accepted AJ, July 2007 publication. Vol 134, p. 14-2

The impact of the urban heat island during an intense heatwave

, an intense heat wave occurred in Oklahoma City. To quantify the impact of the urban heat island (UHI) in Oklahoma City on observed and apparent temperature conditions during the heat wave event, this study used observations from 46 locations in and around Oklahoma City. The methodology utilized composite values of atmospheric conditions for three primary categories defined by population and general land use: rural, suburban, and urban. The results of the analyses demonstrated that a consistent UHI existed during the study period whereby the composite temperature values within the urban core were approximately 0.5 • C warmer during the day than the rural areas and over 2 • C warmer at night. Further, when the warmer temperatures were combined with ambient humidity conditions, the composite values consistently revealed even warmer heat-related variables within the urban environment as compared with the rural zone

Proliferative Tumor Doubling Times of Prostatic Carcinoma

Prostate cancer (PCa) has a variable biology ranging from latent cancer to extremely aggressive tumors. Proliferative activities of cancers may indicate their biological potential. A flow cytometric assay to calculate maximum proliferative doubling times (Tmax) of PCa in radical prostatectomy specimens after preoperative in vivo bromodeoxyuridine (BrdU) infusion is presented. Only 4/17 specimens had tumors large enough for flow cytometric analysis. The Tmax of tumors was similar and ranged from 0.6 to 3.6 months. Tumors had calculated doubling times 2- to 25-fold faster than their matched normal tissue. Variations in labeling index and Tmax were observed within a tumor as well as between different Gleason grades. The observed PSA doubling times (PSA-DT) ranged from 18.4 to 32.0 months, considerably slower than the corresponding Tmax of tumors involved. While lack of data for apoptotic rates is a limitation, apparent biological differences between latent versus aggressive PCa may be attributable to variations in apoptotic rates of these tumors rather than their cell proliferative rates

Spectroscopy and Time Variability of Absorption Lines in the Direction of the Vela Supernova Remnant

We present high resolution (R~75,000), high signal-to-noise (S/N~100) Ca II $\lambda$3933.663 and Na I $\lambda\lambda$5889.951, 5895.924 spectra of 68 stars in the direction of the Vela supernova remnant. The spectra comprise the most complete high resolution, high S/N, optical survey of early type stars in this region of the sky. A subset of the sight lines has been observed at multiple epochs, 1993/1994 and 1996. Of the thirteen stars observed twice, seven have spectra revealing changes in the equivalent width and/or velocity structure of lines, most of which arise from remnant gas. Such time variability has been reported previously for the sight lines towards HD 72089 and HD 72997 by Danks & Sembach (1995) and for HD 72127 by Hobbs et al. (1991). We have confirmed the ongoing time variability of these spectra and present new evidence of variability in the spectra of HD 73658, HD 74455, HD 75309 and HD 75821. We have tabulated Na I and Ca II absorption line information for the sight lines in our sample to serve as a benchmark for further investigations of the dynamics and evolution of the Vela SNR.Comment: 8 pages of text, 4 tables, 16 pages of figures Accepted and to be published in ApJ

The Role of Convection in Redistributing Formaldehyde to the Upper Troposphere Over North America and the North Atlantic during the Summer 2004 INTEX Campaign

Measurements of CH2O from a tunable diode laser absorption spectrometer (TDLAS) were acquired onboard the NASA DC-8 during the summer 2004 INTEX-NA (Intercontinental Chemical Transport Experiment - North America) campaign to test our understanding of convection and production mechanisms in the upper troposphere (UT, 6-12-km) over continental North America and the North Atlantic Ocean. Point-by-point comparisons with box model calculations, when MHP (CH3OOH) measurements were available for model constraint, resulted in a median CH2O measurement/model ratio of 0.91 in the UT. Multiple tracers were used to arrive at a set of UT CH2O background and perturbed air mass periods, and 46% of the TDLAS measurements fell within the latter category. At least 66% to 73% of these elevated UT observations were caused by enhanced production from CH2O precursors rather than direct transport of CH2O from the boundary layer. This distinction is important, since the effects from the former can last for over a week or more compared to one day or less in the case of convective transport of CH2O itself. In general, production of CH2O from CH4 was found to be the dominant source term, even in perturbed air masses. This was followed by production from MHP, methanol, PAN type compounds, and ketones, in descending order of their contribution. In the presence of elevated NO from lightning and potentially from the stratosphere, there was a definite trend in the CH2O discrepancy, which for the highest NO mixing ratios produced a median CH2O measurement/model ratio of 3.9 in the 10-12-km range. Discrepancies in CH2O and HO2 in the UT with NO were highly correlated and this provided further information as to the possible mechanism(s) responsible. These discrepancies with NO are consistent with additional production sources of both gases involving CH3O2 + NO reactions, most likely caused by unmeasured hydrocarbons

Reframing Kurtz’s Painting: Colonial Legacies and Minority Rights in Ethnically Divided Societies

Minority rights constitute some of the most normatively and economically important human rights. Although the political science and legal literatures have proffered a number of constitutional and institutional design solutions to address the protection of minority rights, these solutions are characterized by a noticeable neglect of, and lack of sensitivity to, historical processes. This Article addresses that gap in the literature by developing a causal argument that explains diverging practices of minority rights protections as functions of colonial governments’ variegated institutional practices with respect to particular ethnic groups. Specifically, this Article argues that in instances where colonial governments politicize and institutionalize ethnic hegemony in the pre-independence period, an institutional legacy is created that leads to lower levels of minority rights protections. Conversely, a uniform treatment and depoliticization of ethnicity prior to independence ultimately minimizes ethnic cleavages post-independence and consequently causes higher levels of minority rights protections. Through a highly structured comparative historical analysis of Botswana and Ghana, this Article builds on a new and exciting research agenda that focuses on the role of long-term historio-structural and institutional influences on human rights performance and makes important empirical contributions by eschewing traditional methodologies that focus on single case studies that are largely descriptive in their analyses. Ultimately, this Article highlights both the strength of a historical approach to understanding current variations in minority rights protections and the varied institutional responses within a specific colonial government

University of California Research Seminar Network: A Prospectus

By webcasting the hundreds of seminars presented in the University of California system each week, UC educators hope to enhance the exchange of scientific information for their campuses and create the foundation for an international research seminar network

"‘We just want to be treated with respect!’: Using restorative approaches and the dramatic arts to build positive relationships between the police and young people"

This article explores the application of an ambitious arts-based restorative intervention that has been applied in a direct response to perceived issues with procedural justice, legitimacy and community relations between police and young people. The research focuses on a series of Youth Forums that took place in the West of England, employed as an attempt to improve strained relationships between both parties. It reports on detailed ethnographic research of the Forum processes and procedures presenting this primary evidence in light of the existing literature on police legitimacy and procedural justice in police-youth encounters. The findings suggest that community-based arts programmes can be a powerful and effective tool for challenging entrenched views with the potential to improve future encounters between police and young people; and that the relevance and effectiveness of arts-based interventions can be increased by combining with restorative justice principles