Offrande Nouvelle

Copia digital. Madrid : Ministerio de Cultura. Subdirección General de Coordinación Bibliotecaria, 201

Patterns of Bone Failure in Localized Prostate Cancer Previously Irradiated: The Preventive Role of External Radiotherapy on Pelvic Bone Metastases

Introduction: External beam radiation therapy (EBRT) can cure localized prostate cancer (PCa) by sterilizing cancer cells in the prostate gland and surrounding tissues at risk of microscopic dissemination. We hypothesized that pelvic EBRT for localized PCa might have an unexpected prophylactic impact on the occurrence of pelvic bone metastases.Material and Methods: We reviewed the data of 332 metastatic PCa patients. We examined associations between the number (≤5 vs. >5) and the location of bone metastases (in-field vs. out-of-field), which occurred at first relapse, and a previous history of EBRT for PCa (EBRT vs. No-EBRT).Results: One hundred and ten patients M0 at baseline were eligible. Fifty-six patients (51%) were in the No-EBRT group, and 54 patients (49%) in the EBRT group. The proportion of patients who developed >5 bone metastases in the bony pelvis was higher in the No-EBRT group vs. the EBRT group: 10 patients (18%) vs. 2 patients (4%), respectively (p = 0.02). By multivariate analysis EBRT was associated with a lesser occurrence of patients who had >5 bone metastases in the bony pelvis (OR = 0.17 [95%CI, 0.04–0.87], p = 0.03). Time to occurrence of bone metastases ≥5 years (OR = 0.10 [95%CI, 0.05–0.19], p < 0.01), prior curative prostate treatment (OR = 0.58 [95%CI, 0.36–0.91], p = 0.02), >5 bone metastases in bony pelvis (OR = 2.61 [95%CI, 1.28–5.31], p < 0.01), >5 bone metastases out of bony pelvis (OR = 1.73 [95%CI, 1.09–2.76], p = 0.02) were all predictive of overall survival.Conclusion: Previous pelvic EBRT for PCa is associated with a lower number of pelvic bone metastases, which is associated with better overall survival

Recommendations for radiation therapy in oligometastatic prostate cancer:An ESTRO-ACROP Delphi consensus

Background and purpose: Oligometastatic prostate cancer is a new and emerging treatment field with only few prospective randomized studies published so far. Despite the lack of strong level I evidence, metastasis-directed therapies (MDT) are widely used in clinical practice, mainly based on retrospective and small phase 2 studies and with a large difference across centers. Pending results of ongoing prospec-tive randomized trials, there is a clear need for more consistent treatment indications and radiotherapy practices.Material and methods: A European Society for Radiotherapy and Oncology (ESTRO) Guidelines Committee consisting of radiation oncologists' experts in prostate cancer was asked to answer a dedicated question-naire, including 41 questions on the main controversial issues with regard to oligometastatic prostate cancer.Results: The panel achieved consensus on patient selection and routine use of prostate-specific mem-brane antigen positron emission tomography (PSMA PET) imaging as preferred staging and restaging imaging. MDT strategies are recommended in the de novo oligometastatic, oligorecurrent and oligopro-gressive disease setting for nodal, bone and visceral metastases. Radiation therapy doses, volumes and techniques were discussed and commented.Conclusion: These recommendations have the purpose of providing standardization and consensus to optimize the radiotherapy treatment of oligometastatic prostate cancer until mature results of random-ized trials are available.AT would like to acknowledge the support of Cancer Research UK (C33589/A28284 and C7224/A28724) . This project represents independent research supported by the National Institute for Health research (NIHR) Biomedical Research Centre at The Royal Marsden NHS Foundation Trust and the Institute of Cancer Research, London. The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care

Ma randonnée informatique

National audienceRassembler des explications de ce qu’est la science cache parfois comment une thématique a évolué et s’est construite dans le temps. Interstices a souhaité revenir sur les travaux de Marion Créhange, la première personne à avoir fait une thèse en informatique en France. La présentation qu'elle nous a confiée illustre parfaitement comment les scientifiques traversent leurs disciplines. Plus qu’une vision fermée, elle nous montre les nombreuses possibilités qui ont jalonné son travail, sous forme d’un chemin au travers des montagnes, chères à son cœur

Courbes de Wilson : évaluation d'une nouvelle méthode de mesure passant par les axes dentaires

Wilson’s curves are frontal, generally with superior concavity curves that bring together the tops of the vestibular and lingual cusps of two homologous teeth. To date, few variability studies have been conducted on Wilson’s curves, and even less considering the occurrence of teeth’s abrasion. We have therefore decided to start from the frontal convergence of dental axis passing through the first third/second third apical end of each dental root and running back to the center of each dental crown. Using the metrical and angular values measured on the 3D images of digitized mandibles, the objectives of this work are to propose a new method of measuring Wilson’s Curves removing the dental cusps from consideration (thus removing the impact of occlusal wear) and to compare the results with those of a conventional measurement method. The first section includes the definitions of the different curves in the three dimensions of space, an anatomical summary as well as the objectives of the study. The second section covers the materials and methods used for the study. The third section details the obtained results. The fourth and final section expounds the discussion.Les courbes de Wilson sont des courbes frontales à concavité généralement supérieure réunissant les sommets des cuspides vestibulaires et linguales de deux dents homologues. A ce jour, peu d’études de variabilité ont porté sur les courbes de Wilson, et encore moins en présence de dents abrasées. Nous avons donc décidé de nous inspirer des axes dentaires passant par l’extrémité premier tiers/deuxième tiers apical de chaque racine dentaire et remontant jusqu’au centre de chaque couronne dentaire. A partir des valeurs métriques et angulaires mesurées sur les images 3D de mandibules numérisées, les objectifs de ce travail sont de proposer une nouvelle méthode de mesure des courbes de Wilson, s’affranchissant des cuspides dentaires et donc du facteur d’usure occlusale et de comparer les résultats à ceux issus d’une méthode de mesure conventionnelle. La première partie expose les définitions des différentes courbes dans les trois sens de l’espace, ainsi que des rappels anatomiques et les objectifs de l’étude. La deuxième partie traite des matériels et des méthodes utilisés pour l’étude. La troisième partie détaille les résultats obtenus. La quatrième partie exprime la discussion

Chomage et placement

- Fonds de chômage #21- Le placement #57- Résultats #81- Table des matières #13

Description formelle, représentation, interrogation des informations complexes, système pivoines

Not AvailableEtude d'un générateur de programmes. Un des buts de notre étude est que l'auteur d'un système de données, aussi complexe soit-il, n'ait à fournir à l'ordinateur que des renseignements sur le genre et la représentation des informations que ce système doit traiter et que, pour chaque mise en oeuvre du système, l'utilisateur n'ait à transmettre que l'énoncé de cette mise en oeuvre