A MORE OBJECTIVE PROCEDURE FOR DETERMINING ECONOMIC SUBREGIONS: CLUSTER ANALYSIS

Research Methods/ Statistical Methods,

Simulations of Strong Gravitational Lensing with Substructure

Galactic sized gravitational lenses are simulated by combining a cosmological N-body simulation and models for the baryonic component of the galaxy. The lens caustics, critical curves, image locations and magnification ratios are calculated by ray-shooting on an adaptive grid. When the source is near a cusp in a smooth lens' caustic the sum of the magnifications of the three closest images should be close to zero. It is found that in the observed cases this sum is generally too large to be consistent with the simulations implying that there is not enough substructure in the simulations. This suggests that other factors play an important role. These may include limited numerical resolution, lensing by structure outside the halo, selection bias and the possibility that a randomly selected galaxy halo may be more irregular, for example due to recent mergers, than the isolated halo used in this study. It is also shown that, with the level of substructure computed from the N-body simulations, the image magnifications of the Einstein cross type lenses are very weak functions of source size up to \sim 1\kpc. This is also true for the magnification ratios of widely separated images in the fold and cusp caustic lenses. This means that selected magnification ratios for different the emission regions of a lensed quasar should agree with each other, barring microlensing by stars. The source size dependence of the magnification ratio between the closest pair of images is more sensitive to substructure.Comment: 28 pages, 2 tables and 14 figures. Accepted to MNRA

Molecular Star Formation Rate Indicators in Galaxies

We derive a physical model for the observed relations between star formation rate (SFR) and molecular line (CO and HCN) emission in galaxies, and show how these observed relations are reflective of the underlying star formation law. We do this by combining 3D non-LTE radiative transfer calculations with hydrodynamic simulations of isolated disk galaxies and galaxy mergers. We demonstrate that the observed SFR-molecular line relations are driven by the relationship between molecular line emission and gas density, and anchored by the index of the underlying Schmidt law controlling the SFR in the galaxy. Lines with low critical densities (e.g. CO J=1-0) are typically thermalized and trace the gas density faithfully. In these cases, the SFR will be related to line luminosity with an index similar to the Schmidt law index. Lines with high critical densities greater than the mean density of most of the emitting clouds in a galaxy (e.g. CO J=3-2, HCN J=1-0) will have only a small amount of thermalized gas, and consequently a superlinear relationship between molecular line luminosity and mean gas density. This results in a SFR-line luminosity index less than the Schmidt index for high critical density tracers. One observational consequence of this is a significant redistribution of light from the small pockets of dense, thermalized gas to diffuse gas along the line of sight, and prodigious emission from subthermally excited gas. At the highest star formation rates, the SFR-Lmol slope tends to the Schmidt index, regardless of the molecular transition. The fundamental relation is the Kennicutt-Schmidt law, rather than the relation between SFR and molecular line luminosity. We use these results to make imminently testable predictions for the SFR-molecular line relations of unobserved transitions.Comment: ApJ Accepted - Results remain same as previous version. Content clarified with Referee's comment

Development of Guidelines for In-Situ Repair of SLS-Class Composite Flight Hardware

The purpose of composite repair development at KSC (John F. Kennedy Space Center) is to provide support to the CTE (Composite Technology for Exploration) project. This is a multi-space center effort with the goal of developing bonded joint technology for SLS (Space Launch System) -scale composite hardware. At KSC, effective and efficient repair processes need to be developed to allow for any potential damage to composite components during transport or launch preparation. The focus of the composite repair development internship during the spring of 2018 was on the documentation of repair processes and requirements for process controls based on techniques developed through hands-on work with composite test panels. Three composite test panels were fabricated for the purpose of repair and surface preparation testing. The first panel included a bonded doubler and was fabricated to be damaged and repaired. The second and third panels were both fabricated to be cut into lap-shear samples to test the strength of bond of different surface preparation techniques. Additionally, jointed composite test panels were impacted at MSFC (Marshall Space Flight Center) and analyzed for damage patterns. The observations after the impact tests guided the repair procedure at KSC to focus on three repair methods. With a finalized repair plan in place, future work will include the strength testing of different surface preparation techniques, demonstration of repair methods, and repair of jointed composite test panels being impacted at MSFC

Socio-Economic Analysis of Upstream Watershed Development in Oklahoma

Agricultural Economic

A Physical Model for the Origin of Quasar Lifetimes

We propose a model of quasar lifetimes in which observational quasar lifetimes and an intrinsic lifetime of rapid accretion are strongly distinguished by the physics of obscuration by surrounding gas and dust. Quasars are powered by gas funneled to galaxy centers, but for a large part of the accretion lifetime are heavily obscured by the large gas densities powering accretion. In this phase, starbursts and black hole growth are fueled but the quasar is buried. Eventually, feedback from accretion energy disperses surrounding gas, creating a window in which the black hole is observable optically as a quasar, until accretion rates drop below those required to maintain a quasar luminosity. We model this process and measure the unobscured and intrinsic quasar lifetimes in a hydrodynamical simulation of a major galaxy merger. The source luminosity is determined from the black hole accretion rate, calculated from local gas properties. We calculate the column density of hydrogen to the source along multiple lines of sight and use these column densities and gas metallicities to determine B-band attenuation of the source. Defining the observable quasar lifetime as the total time with an observed B-band luminosity above some limit L_B,min, we find lifetimes ~10-20 Myr for L_B,min=10^11 L_sun (M_B=-23), in good agreement with observationally determined quasar lifetimes. This is significantly smaller than the intrinsic lifetime ~100 Myr obtained if attenuation is neglected. The ratio of observed to intrinsic lifetime is also strong function of both the limiting luminosity and the observed frequency.Comment: 5 pages, 4 figures, submitted to ApJ Letter

Hydroxyl radical is produced via the Fenton reaction in submitochondrial particles under oxidative stress: implications for diseases associated with iron accumulation

Mitochondrial dysfunction and reactive oxygen species (ROS) are often implicated in diseases involving oxidative stress and elevated iron. As mitochondria produce ATP by oxidative phosphorylation, ROS by-products are generated from the electron transport chain. Although superoxide and hydrogen peroxide have been thoroughly investigated, little evidence documents hydroxyl radical (HO•) production in mitochondria. In order to determine whether HO• is generated under oxidative stress conditions by a Fenton-type mechanism, bovine heart submitochondrial particles were examined for HO• in the presence and absence of iron ligands, antioxidant enzymes and HO• scavengers. HO• was measured as 2,3- and 2,5-dihydroxybenzoic acid (DHBA), using HPLC with electrochemical detection. The iron ligand desferrioxamine significantly decreased DHBAs, indicating that HO• generation required iron redox-cycling. In addition, results from exogenous SOD and catalase, exogenous hydrogen peroxide, and HO•-scavenger studies support a Fenton-type reaction mechanism. The results indicate that increased HO• levels occur in mitochondria under oxidative stress and that the HO• levels can be modulated with antioxidant enzymes and iron ligands. Our findings together with reports on iron accumulation in degenerative diseases highlight the importance of developing mitochondrial-targeted antioxidants for the therapeutic intervention of diseases associated with mitochondrial dysfunction and oxidative stress

Evasion of autophagy mediated by Rickettsia surface protein OmpB is critical for virulence.

Rickettsia are obligate intracellular bacteria that evade antimicrobial autophagy in the host cell cytosol by unknown mechanisms. Other cytosolic pathogens block different steps of autophagy targeting, including the initial step of polyubiquitin-coat formation. One mechanism of evasion is to mobilize actin to the bacterial surface. Here, we show that actin mobilization is insufficient to block autophagy recognition of the pathogen Rickettsia parkeri. Instead, R. parkeri employs outer membrane protein B (OmpB) to block ubiquitylation of the bacterial surface proteins, including OmpA, and subsequent recognition by autophagy receptors. OmpB is also required for the formation of a capsule-like layer. Although OmpB is dispensable for bacterial growth in endothelial cells, it is essential for R. parkeri to block autophagy in macrophages and to colonize mice because of its ability to promote autophagy evasion in immune cells. Our results indicate that OmpB acts as a protective shield to obstruct autophagy recognition, thereby revealing a distinctive bacterial mechanism to evade antimicrobial autophagy

Reshaping the tumor stroma for treatment of pancreatic cancer

Pancreatic cancer is accompanied by a fibrotic reaction that alters interactions between tumor cells and the stroma to promote tumor progression. Consequently, strategies to target the tumor stroma might be used to treat patients with pancreatic cancer. We review recently developed approaches for reshaping the pancreatic tumor stroma and discuss how these might improve patient outcomes. We also describe relationships between the pancreatic tumor extracellular matrix, the vasculature, the immune system, and metabolism, and discuss the implications for the development of stromal compartment−specific therapies