An Evaluation of Clean the World, Las Vegas Volunteer Program

Background Student evaluation team, AVID Advising, conducted an evaluation of a not for profit organization, Clean the World, Las Vegas Volunteer Program from February 2015 through August 2015. The pre-­‐ valuation consisted of an analysis of the organization’s growth since opening its Las Vegas doors in 2012, staff responsibilities, and their volunteer program. As a result of the pre-­‐ valuation, AVID Advising and Clean the World Las Vegas Manager, Kevin Williams determined an evaluation on the existing volunteer program would be most beneficial to the organization. Purpose The primary purpose of this evaluation is to provide Clean the World, Las Vegas with both short and long term recommendations based on the identified needs of their current volunteer program. Methodology To obtain qualitative and quantitative information about the volunteer program, information was collected via interviews with Clean the World, Las Vegas staff members, found in benchmarks studies, and through surveys ADIV Advising developed and distributed to current volunteers. Findings The volunteer survey respondents were able to provide important critical feedback regarding the volunteer program; survey data and commen

The Effects of Water Ice Sublimation on Slope Failures of Icy Regolith

The frost line in a planetary system represents the distance from the central star inside of which conditions are too warm for ice to form, while beyond this line it will be stable. When an icy object passes that line heading toward the Sun it will begin to sublimate and outgas, potentially causing mass loss and surface changes. One example is surface failures, which can lead to material being removed from the object. Evidence of this has been seen on cometary surfaces, where surfaces often show structures that appear to have suffered various mechanical failures like cracking and landslides. By mixing water ice with sand and using a vacuum chamber to simulate the vacuum conditions of space, we monitored what happened as sublimation caused an evolution of the ice-sand mixture. Failures in the sample were observed from the top and the side by watching time-lapse videos of over 24 hour period created during the experiment run. We observed that the samples with more total material tended to show more activity and that samples with higher water concentrations continued to show “Erosion” features for a longer period of time. Additionally, these higher water concentration samples showed larger failure features later in the runs, when the sample strength was much lower. While these were proof-of-concept experiments, the dependencies and observational notes may be applied to the interpretation of observations of comets in the Solar System

Advocating for Occupational Therapy’s Role in Secondary Stroke Prevention

Background: Cerebrovascular Accident (CVA), or stroke, is a leading cause of death and a major source of disability in the United States (Centers for Disease Control and Prevention [CDC], 2017). Stroke is classically characterized as a neurological deficit attributed to an acute focal injury of the central nervous system (CNS) by a vascular cause de (Sacco, et al., 2013). Vascular causes include cerebral infarction, intracerebral hemorrhage (ICH), and subarachnoid hemorrhage (SAH). and is a major cause of disability and death worldwide (Sacco, et al., 2013). Stroke and transient ischemic attack (TIA) patients are at a high risk for a subsequent event. Each year, 15 million people worldwide will have a stroke. In America, the number of people who will have a stroke this year is approximately 795,000. Of that large number, 25% of stroke patients will have a secondary stroke within 5 years (Flach, 2020). A high number of secondary stroke events presents a need to develop interventions and strategies to decrease the prevalence. Purpose: The purpose of the capstone project is to define the role of occupational therapy in secondary stroke prevention. Occupational therapists are an integral part of the rehabilitation process and can offer a holistic approach to prevent second strokes. Identifying the role of occupational therapy within secondary stroke prevention will help to bring an occupation-based approach to secondary stroke prevention to increase participant’s volition and create/modify habits. This will foster a healthier lifestyle and ultimately reduce the likelihood of a second stroke. Awareness of the role of an occupational therapist will also help to educate the interdisciplinary team working within the stroke care continuum. This paper will also help advocate for the role of occupational therapy in secondary stroke prevention by clearly defining the role. Methods and Results: Qualitative data was obtained through a needs assessment that included interviews, observations and survey completions of 15 stroke patients and 20 occupational therapy practitioners over the course of 12 weeks. The results from the needs assessment, along with the thorough literature review allowed the student investigator to define the role of occupational therapy in secondary stroke prevention. Conclusion: The qualitative study identifies the unique role of occupational therapy within secondary stroke prevention. Occupational therapy practitioners have the expertise to provide stroke patients with client-centered education, health promotion, self-care skills, fine and gross motor skills, functional mobility, core strength, sensory processing, visual-motor skills, praxis, range of motion, strength, cognition, behavioral health and more. All of these occupation-based interventions work to reduce the likelihood of a secondary stroke event. Advocacy for occupational therapy in secondary stroke prevention is needed, as there is limited literature outlining the role and expertise. Occupational therapy has an impactful and unique role in secondary stroke prevention.https://soar.usa.edu/otdcapstonesfall2021/1000/thumbnail.jp

Risk of acquired drug resistance during short-course directly observed treatment of tuberculosis in an area with high levels of drug resistance.

BACKGROUND: Data on the performance of standardized short-course directly observed treatment (DOTS) of tuberculosis (TB) in areas with high levels of drug resistance and on the potential impact of DOTS on amplification of resistance are limited. Therefore, we analyzed treatment results from a cross-sectional sample of patients with TB enrolled in a DOTS program in an area with high levels of drug resistance in Uzbekistan and Turkmenistan in Central Asia. METHODS: Sputum samples for testing for susceptibility to 5 first-line drugs and for molecular typing were obtained from patients starting treatment in 8 districts. Patients with sputum smear results positive for TB at the end of the intensive phase of treatment and/or at 2 months into the continuation phase were tested again. RESULTS. Among 382 patients with diagnoses of TB, 62 did not respond well to treatment and were found to be infected with an identical Mycobacterium tuberculosis strain when tested again; 19 of these patients had strains that developed new or additional drug resistance. Amplification occurred in only 1.2% of patients with initially susceptible or monoresistant TB strains, but it occurred in 17% of those with polyresistant strains (but not multidrug-resistant strains, defined as strains with resistance to at least isoniazid and rifampicin) and in 7% of those with multidrug-resistant strains at diagnosis. Overall, 3.5% of the patients not initially infected with multidrug-resistant TB strains developed such strains during treatment. Amplification of resistance, however, was found only in polyresistant Beijing genotype strains. CONCLUSIONS: High levels of amplification of drug resistance demonstrated under well-established DOTS program conditions reinforce the need for implementation of DOTS-Plus for multidrug-resistant TB in areas with high levels of drug resistance. The strong association of Beijing genotype and amplification in situations of preexisting resistance is striking and may underlie the strong association between this genotype and drug resistance

Regolith behavior under asteroid-level gravity conditions: Low-velocity impacts into mm- and cm-sized grain targets

In situ observations of small asteroids show that surfaces covered by boulders and coarse terrain are frequent on such bodies. Regolith grain sizes have distributions on approximately mm and cm scales, and the behavior of such large grains in the very low-gravity environments of small body surfaces dictates their morphology and evolution. In order to support the understanding of natural processes (e.g., the recapturing of impact ejecta) or spacecraft-induced interactions (e.g., the fate of a small lander), we aim to experimentally investigate the response of coarse-grained target surfaces to very-low-speed impacts (below 2 m/s). We present the outcome of 86 low-speed impacts of a cm-sized spherical projectile into a bed of simulated regolith, composed of irregular mm- and cm-sized grains. These impacts were performed under vacuum and microgravity conditions. Our results include measurements for the projectile coefficient of restitution and penetration depth, as well as ejecta production, speed, and mass estimation. We find that impact outcomes include the frequent occurrence of projectile bouncing and tangential rolling on the target surface upon impact. Ejecta is produced for impact speeds higher than about 12 cm/s, and ejecta speeds scale with the projectile to target the grain size ratio and the impact speed. Ejected mass estimations indicate that ejecta is increasingly difficult to produce for increasing grain sizes. Coefficients of restitution of rebounding projectiles do not display a dependency on the target grain size, unlike their maximum penetration depth, which can be scaled with the projectile to target grain size ratio. Finally, we compare our experimental measurements to spacecraft data and numerical work on Hayabusa 2's MASCOT landing on the surface of the asteroid Ryugu

Natural Observation of Alcohol Price and Promotions at Bars: Implications for Alcohol Misuse Prevention

Alcohol misuse among young adults remains a primary public health concern given the wide range of short- and longterm physical, social, and societal consequences of the behavior. On-premise drinking establishments, which allow alcohol consumption on site (i.e., bars), are frequent locations for young adult alcohol use. Risks for alcohol misuse within the bar setting are key factors to identify for prevention. Notably, alcohol price and promotions are associated with alcohol consumption among young adults. This study sought to develop and pilot test an observational protocol to assess the alcohol environment at on-premise drinking establishments. Following qualitative exploration of salient risk factors in these settings through focus groups with young adults, an observational tool was adapted and tested in a feasibility study. The refined tool was then pilot tested with two independent data collectors conducting natural observation at 13 establishments in the downtown nightlife district of a small, southeastern city. High interrater reliability was noted. Descriptive summary statistics of bar characteristics demonstrate low alcohol prices with variability across types of alcohol (e.g., beer, wine, and liquor), greater numbers of alcohol promotions inside rather than outside the building, and higher rates of manual versus electronic age verification procedures. Observational assessment of alcohol price and marketing at on-premise drinking establishments as described in this study is needed to inform prevention policy and programs to reduce harms associated with young adult alcohol misuse

Microtomographic reconstruction of mandibular defects treated with xenografts and collagen-based membranes:a pre-clinical minipig model

The goal of this study was to evaluate hard tissue response following guided bone regeneration using commercially available bovine bone grafts and collagen membranes; bilayer collagen membrane and porcine pericardium-based membrane, by means of a non-destructive three-dimensional (3D) computerized volumetric analysis following microtomography reconstruction. Bone regenerative properties of various bovine bone graft materials were evaluated in the Göttingen minipig model. Two standardized intraosseous defects (15mm x 8mm x 8mm) were created bilaterally of the mandible of eighteen animals (n=72 defects). Groups were nested within the same subject and randomly distributed among the sites: (i) negative control (no graft and membrane), (ii) bovine bone graft/bilayer collagen membrane (BOB) (iii) Bio-Oss® bone graft/porcine pericardium-based membrane (BOJ) and (iv) cerabone® bone graft/porcine pericardium-based membrane (CJ). Samples were harvested at 4, 8, and 12-week time points (n=6 animal/time point). Segments were scanned using computerized microtomography (?CT) and three dimensionally reconstructed utilizing volumetric reconstruction software. Statistical analyses were performed using IBM SPSS with a significance level of 5%. From a temporal perspective, tridimensional evaluation revealed gradual bone ingrowth with the presence of particulate bone grafts bridging the defect walls, and mandibular architecture preservation over time. Volumetric analysis demonstrated no significant difference between all groups at 4 weeks (p>0.127). At 8 and 12 weeks there was a higher percentage of new bone formation for control and CJ groups when compared to BOB and BOJ groups (p<0.039). The natural bovine bone graft group showed more potential for graft resorption over time relative to bovine bone graft, significantly different between 4 and 8 weeks (p<0.003). Volumetric analysis yielded a favorable mandible shape with respect to time through the beneficial balance between graft resorption/bone regenerative capacity for the natural bovine bone graft

Onset of negative interspike interval correlations in adapting neurons

Negative serial correlations in single spike trains are an effective method to reduce the variability of spike counts. One of the factors contributing to the development of negative correlations between successive interspike intervals is the presence of adaptation currents. In this work, based on a hidden Markov model and a proper statistical description of conditional responses, we obtain analytically these correlations in an adequate dynamical neuron model resembling adaptation. We derive the serial correlation coefficients for arbitrary lags, under a small adaptation scenario. In this case, the behavior of correlations is universal and depends on the first-order statistical description of an exponentially driven time-inhomogeneous stochastic process.Comment: 12 pages (10 pages in the journal version), 6 figures, published in Phys. Rev. E; http://link.aps.org/doi/10.1103/PhysRevE.84.04190

Lidocaine Induces Endoplasmic Reticulum Stress-Associated Apoptosis in Vitro and in Vivo

We demonstrated that upregulation of both gene expression of endoplasmic reticulum (ER) stress chaperones (BiP, calnexin, calreticulin, and PDI) and ER stress sensors (ATF6, IRE1 and PERK) was induced by lidocaine, a local anesthetic, in PC12 cells. In addition to gene regulation, lidocaine also induced typical ER stress phenomena such as ART6 proteolytic cleavage, eIF2 alpha phosphorylation, and XBP1 mRNA splicing. In in vivo experiments, while lidocaine downregulated gene expression of antiapoptotic factors (Bcl-2 and Bcl-xl), pro-apoptotic factor (Bak and Bax) gene expression was upregulated. Furthermore, lidocaine induced apoptosis, as measured histochemically, and upregulated PARP1, a DNA damage repair enzyme. These results are the first to show that lidocaine induces apoptosis through ER stress in vitro and in vivo