Production of a pion in association with a high-Q2 dilepton pair in antiproton-proton annihilation at GSI-FAIR

We evaluate the cross section for anti-p p -> l+ l- pi0 in the forward direction and for large lepton pair invariant mass. In this kinematical region, the leading-twist amplitude factorises into a short-distance matrix element, long-distance dominated antiproton Distribution Amplitudes and proton to pion Transition Distribution Amplitudes (TDA). Using a modelling inspired from the chiral limit for these TDAs, we obtain a first estimate of this cross section, thus demonstrating that this process can be measured at GSI-FAIR.Comment: Latex, 5 pages, 3 figure

A quantitative model of traffic between plasma membrane and secondary lysosomes: evaluation of inflow, lateral diffusion, and degradation.

We present here a mathematical model that accounts for the various proportions of plasma membrane constituents occurring in the lysosomal membrane of rat fibroblasts (Draye, J.-P., J. Quintart, P. J. Courtoy, and P. Baudhuin. 1987. Eur. J. Biochem. 170: 395-403; Draye, J.-P., P. J. Courtoy, J. Quintart, and P. Baudhuin. 1987. Eur. J. Biochem. 170:405-411). It is based on contents of plasma membrane markers in purified lysosomal preparations, evaluations of their half-life in lysosomes and measurements of areas of lysosomal and plasma membranes by morphometry. In rat fibroblasts, structures labeled by a 2-h uptake of horseradish peroxidase followed by a 16-h chase (i.e., lysosomes) occupy 3% of the cellular volume and their total membrane area corresponds to 30% of the pericellular membrane area. Based on the latter values, the model predicts the rate of inflow and outflow of plasma membrane constituents into lysosomal membrane, provided their rate of degradation is known. Of the bulk of polypeptides iodinated at the cell surface, only 4% reach the lysosomes every hour, where the major part (integral of 83%) is degraded with a half-life in lysosomes of integral to 0.8 h. For specific plasma membrane constituents, this model can further account for differences in the association to the lysosomal membrane by variations in the rate either of lysosomal degradation, of inflow along the pathway from the pericellular membrane to the lysosomes, or of lateral diffusion

Transverse-Momentum Distributions and Spherical Symmetry

Transverse-momentum dependent parton distributions (TMDs) are studied in the framework of quark models. In particular, quark model relations among TMDs are reviewed and their physical origin is discussed in terms of rotational-symmetry properties of the nucleon state in its rest frame.Comment: 8 pages, 2 figures, prepared for the workshop "30 years of strong interactions", Spa, Belgium, 6-8 April 201

Confinement, the gluon propagator and the interquark potential for heavy mesons

The interquark static potential for heavy mesons described by a massive One Gluon Exchange interaction obtained from the propagator of the truncated Dyson-Schwinger equations does not reproduced the expected Cornell potential. I show that no formulation based on a finite propagator will lead to confinement of quenched QCD. I propose a mechanism based on a singular nonperturbative coupling constant which has the virtue of giving rise to a finite gluon propagator and (almost) linear confinement. The mechanism can be slightly modified to produce the screened potentials of unquenched QCD.Comment: 12 pages and 7 figure

Model analysis of the world data on the pion transition form factor

We discuss the impact of recent Belle data on our description of the pion transition form factor based on the assumption that a perturbative formalism and a nonperturbative one can be matched in a physically acceptable manner at a certain hadronic scale $Q_{0}$. We discuss the implications of the different parameters of the model in comparing with world data and conclude that within experimental errors our description remains valid. Thus we can assert that the low $Q^2$ nonperturbative description together with an additional $1/Q^2$ term at the matching scale have a strong influence on the $Q^2$ behavior up to very high values of $Q^2$ .Comment: 6 pages and 3 figures. Contains a comparison with other models and additional reference

Dietary supplementation of cystinotic mice by lysine inhibits the megalin pathway and decreases kidney cystine content.

peer reviewedMegalin/LRP2 is a major receptor supporting apical endocytosis in kidney proximal tubular cells. We have previously reported that kidney-specific perinatal ablation of the megalin gene in cystinotic mice, a model of nephropathic cystinosis, essentially blocks renal cystine accumulation and partially preserves kidney tissue integrity. Here, we examined whether inhibition of the megalin pathway in adult cystinotic mice by dietary supplementation (5x-fold vs control regular diet) with the dibasic amino-acids (dAAs), lysine or arginine, both of which are used to treat patients with other rare metabolic disorders, could also decrease renal cystine accumulation and protect cystinotic kidneys. Using surface plasmon resonance, we first showed that both dAAs compete for protein ligand binding to immobilized megalin in a concentration-dependent manner, with identical inhibition curves by L- and D-stereoisomers. In cystinotic mice, 2-month diets with 5x-L-lysine and 5x-L-arginine were overall well tolerated, while 5x-D-lysine induced strong polyuria but no weight loss. All diets induced a marked increase of dAA urinary excretion, most prominent under 5x-D-lysine, without sign of kidney insufficiency. Renal cystine accumulation was slowed down approx. twofold by L-dAAs, and totally suppressed by D-lysine. We conclude that prolonged dietary manipulation of the megalin pathway in kidneys is feasible, tolerable and can be effective in vivo