2,261 research outputs found
Development and operation of the twin radio frequency single electron transistor for solid state qubit readout
Ultra-sensitive detectors and readout devices based on the radio frequency
single electron transistor (rf-SET) combine near quantum-limited sensitivity
with fast operation. Here we describe a twin rf-SET detector that uses two
superconducting rf-SETs to perform fast, real-time cross-correlated
measurements in order to distinguish sub-electron signals from charge noise on
microsecond time-scales. The twin rf-SET makes use of two tuned resonance
circuits to simultaneously and independently address both rf-SETs using
wavelength division multiplexing (WDM) and a single cryogenic amplifier. We
focus on the operation of the twin rf-SET as a charge detector and evaluate the
cross-talk between the two resonance circuits. Real time suppression of charge
noise is demonstrated by cross correlating the signals from the two rf-SETs.
For the case of simultaneous operation, the rf-SETs had charge sensitivities of
and .Comment: Updated version, including new content. Comments most welcome:
[email protected] or [email protected]
Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Development of portable NMR polarimeter system for polarized HD target
A portable NMR polarimeter system has been developed to measure the
polarization of a polarized Hydrogen-Deuteride (HD) target for hadron
photoproduction experiments at SPring-8. The polarized HD target is produced at
the Research Center for Nuclear Physics (RCNP), Osaka university and is
transported to SPring-8. The HD polarization should be monitored at both
places. We have constructed the portable NMR polarimeter system by replacing
the devices in the conventional system with the software system with PCI
eXtensions for Instrumentation (PXI). The weight of the NMR system is downsized
from 80 kg to 7 kg, and the cost is reduced to 25%. We check the performance of
the portable NMR polarimeter system. The signal-to-noise (S/N) ratio of the NMR
signal for the portable system is about 50% of that for the conventional NMR
system. This performance of the portable NMR system is proved to be compatible
with the conventional NMR system for the polarization measurement.Comment: 6 page, 8 figures, 2011/Mar/9 Replace Author
A GPU-based finite-size pencil beam algorithm with 3D-density correction for radiotherapy dose calculation
Targeting at the development of an accurate and efficient dose calculation
engine for online adaptive radiotherapy, we have implemented a finite size
pencil beam (FSPB) algorithm with a 3D-density correction method on GPU. This
new GPU-based dose engine is built on our previously published ultrafast FSPB
computational framework [Gu et al. Phys. Med. Biol. 54 6287-97, 2009].
Dosimetric evaluations against Monte Carlo dose calculations are conducted on
10 IMRT treatment plans (5 head-and-neck cases and 5 lung cases). For all
cases, there is improvement with the 3D-density correction over the
conventional FSPB algorithm and for most cases the improvement is significant.
Regarding the efficiency, because of the appropriate arrangement of memory
access and the usage of GPU intrinsic functions, the dose calculation for an
IMRT plan can be accomplished well within 1 second (except for one case) with
this new GPU-based FSPB algorithm. Compared to the previous GPU-based FSPB
algorithm without 3D-density correction, this new algorithm, though slightly
sacrificing the computational efficiency (~5-15% lower), has significantly
improved the dose calculation accuracy, making it more suitable for online IMRT
replanning
A Measurement of the Electric Form Factor of the Neutron through at (GeV/c)
We report the first measurement of the neutron electric form factor
via using a solid polarized target. was
determined from the beam-target asymmetry in the scattering of longitudinally
polarized electrons from polarized deuterated ammonia, ND. The
measurement was performed in Hall C at Thomas Jefferson National Accelerator
Facility (TJNAF) in quasi free kinematics with the target polarization
perpendicular to the momentum transfer. The electrons were detected in a
magnetic spectrometer in coincidence with neutrons in a large solid angle
segmented detector. We find at (GeV/c).Comment: Latex2e 5 pages, 3 figure
Nationalism, ethnicity and religion: Fundamental conflicts and the politics of identity in Tanzania
Impact of the PROFHER trial findings on surgeons' clinical practice : An online questionnaire survey
OBJECTIVES: To explore whether orthopaedic surgeons have adopted the Proximal Fracture of the Humerus: Evaluation by Randomisation (PROFHER) trial results routinely into clinical practice. METHODS: A questionnaire was piloted with six orthopaedic surgeons using a 'think aloud' process. The final questionnaire contained 29 items and was distributed online to surgeon members of the British Orthopaedic Association and British Elbow and Shoulder Society. Descriptive statistics summarised the sample characteristics and fracture treatment of respondents overall, and grouped them by whether they changed practice based on PROFHER trial findings. Free-text responses were analysed qualitatively for emerging themes using Framework Analysis principles. RESULTS: There were complete responses from 265 orthopaedic and trauma surgeons who treat patients with proximal humeral fractures. Around half (137) had changed practice to various extents because of PROFHER, by operating on fewer PROFHER-eligible fractures. A third (43) of the 128 respondents who had not changed practice were already managing patients non-operatively. Those who changed practice were more likely to be younger, work in a trauma unit rather than a major trauma centre, be specialist shoulder surgeons and treat fewer PROFHER-eligible fractures surgically. This group gave higher scores when assessing validity and applicability of PROFHER. In contrast, a quarter of the non-changers were critical, sometimes emphatically, of PROFHER. The strongest theme that emerged overall was the endorsement of evidence-based practice. CONCLUSION: PROFHER has had an impact on surgeons' clinical practice, both through changing it, and through underpinning existing non-operative practice. Although some respondents expressed reservations about the trial, evidence from such trials was found to be the most important influence on surgeons' decisions to change practice.Cite this article: L. Jefferson, S. Brealey, H. Handoll, A. Keding, L. Kottam, I. Sbizzera, A. Rangan. Impact of the PROFHER trial findings on surgeons' clinical practice: An online questionnaire survey. Bone Joint Res 2017;6:590-599. DOI: 10.1302/2046-3758.610.BJR-2017-0170
Measurement of Angular Distributions and R= sigma_L/sigma_T in Diffractive Electroproduction of rho^0 Mesons
Production and decay angular distributions were extracted from measurements
of exclusive electroproduction of the rho^0(770) meson over a range in the
virtual photon negative four-momentum squared 0.5< Q^2 <4 GeV^2 and the
photon-nucleon invariant mass range 3.8< W <6.5 GeV. The experiment was
performed with the HERMES spectrometer, using a longitudinally polarized
positron beam and a ^3He gas target internal to the HERA e^{+-} storage ring.
The event sample combines rho^0 mesons produced incoherently off individual
nucleons and coherently off the nucleus as a whole. The distributions in one
production angle and two angles describing the rho^0 -> pi+ pi- decay yielded
measurements of eight elements of the spin-density matrix, including one that
had not been measured before. The results are consistent with the dominance of
helicity-conserving amplitudes and natural parity exchange. The improved
precision achieved at 47 GeV,
reveals evidence for an energy dependence in the ratio R of the longitudinal to
transverse cross sections at constant Q^2.Comment: 15 pages, 15 embedded figures, LaTeX for SVJour(epj) document class
Revision: Fig. 15 corrected, recent data added to Figs. 10,12,14,15; minor
changes to tex
Calcium Homeostasis in Myogenic Differentiation Factor 1 (MyoD)-Transformed, Virally-Transduced, Skin-Derived Equine Myotubes
Dysfunctional skeletal muscle calcium homeostasis plays a central role in the pathophysiology of several human and animal skeletal muscle disorders, in particular, genetic disorders associated with ryanodine receptor 1 (RYR1) mutations, such as malignant hyperthermia, central core disease, multiminicore disease and certain centronuclear myopathies. In addition, aberrant skeletal muscle calcium handling is believed to play a pivotal role in the highly prevalent disorder of Thoroughbred racehorses, known as Recurrent Exertional Rhabdomyolysis. Traditionally, such defects were studied in human and equine subjects by examining the contractile responses of biopsied muscle strips exposed to caffeine, a potent RYR1 agonist. However, this test is not widely available and, due to its invasive nature, is potentially less suitable for valuable animals in training or in the human paediatric setting. Furthermore, increasingly, RYR1 gene polymorphisms (of unknown pathogenicity and significance) are being identified through next generation sequencing projects. Consequently, we have investigated a less invasive test that can be used to study calcium homeostasis in cultured, skin-derived fibroblasts that are converted to the muscle lineage by viral transduction with a MyoD (myogenic differentiation 1) transgene. Similar models have been utilised to examine calcium homeostasis in human patient cells, however, to date, there has been no detailed assessment of the cells’ calcium homeostasis, and in particular, the responses to agonists and antagonists of RYR1. Here we describe experiments conducted to assess calcium handling of the cells and examine responses to treatment with dantrolene, a drug commonly used for prophylaxis of recurrent exertional rhabdomyolysis in horses and malignant hyperthermia in humans
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