7 research outputs found
Peptides originally derived from Chilobrachys jingzhao tarantula venom possess beneficial effects on pancreatic beta cell health and function
Therapeutic Potential of Peptides Derived from Animal Venoms: Current Views and Emerging Drugs for Diabetes
A novel peptide isolated from Aphonopelma chalcodes tarantula venom with benefits on pancreatic islet function and appetite control
Sustained metabolic benefits of ΔTRTX‐Ac1, a tarantula venom‐derived peptide, when administered together with exenatide in high‐fat fed mice
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Lung infections with , a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.Wellcome Trust (Grant IDs: 098051, 107032AIA), Medical Research Council, UK Cystic Fibrosis Trust, Papworth Hospital, National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre, NIHR Specialist Respiratory Biomedical Research Unit, Imperial College London, The UK Clinical Research Collaboration Translational Infection Research Initiative, CF Foundation Therapeutics grant, Australian National Health and Medical Research Council, The Prince Charles Hospital Foundation, National Services Division NHS Scotlan