Accounting for human rights : doxic health and safety practices - the accounting lessons from ICL

This paper is concerned with a specific human right - the right to work in a safe environment. It sets out a case for developing a new form of account of health and safety in any organisational setting. It draws upon the theoretical insights of Pierre Bourdieu taking inspiration from his assertion that in order to understand the 'logic' of the worlds we live in we need to immerse ourselves into the particularity of an empirical reality. In this case the paper, analyses a preventable industrial disaster which occurred in Glasgow, Scotland which killed nine people and injured 33 others. From this special case of what is possible, the paper unearths the underlying structures of symbolic violence of the UK State, the Health and Safety Executive and capital with respect to health and safety at work. While dealing with one specific country (Scotland), the analysis can be used to question health and safety regimes and other forms of symbolic violence across the globe

Characterization, cloning and immunogenicity of antigens released by lung-stage larvae of Schistosoma mansoni

Lung-stage schistosomula are the target of protective immunity in mice vaccinated with attenuated cercariae of Schistosoma mansoni. Therefore, proteins present at this developmental stage, and in particular those which are secreted, are a potential source of novel vaccine candidates. However, little information is available about such molecules. Here we describe the cDNA clones identified by screening expression libraries with serum raised against proteins released by lung-stage schistosomula. In total, 11 different cDNA species were identified, 6 of which have been described previously in S. mansoni; these included fructose 1,6-bisphosphate aldolase and Sm21.7 which together accounted for two-thirds of all positive clones. Of the 5 newly described schistosome genes, 1 cDNA had a high degree of homology to the s5a subunit of 26S proteasomes, most significant being with the human protein. The remaining 4 clones showed no significant homologies to any genes sequenced previously. Fructose 1,6-bisphosphate aldolase, Sm21.7, the proteasome homologue and 1 unknown clone (A26) have been expressed in a bacterial expression system and serum produced against each recombinant protein. Immunolocalization showed fructose 1,6-bisphosphate aldolase, Sm21.7 and the proteasome homologue to be most abundant in muscle cells whilst clone A26 was distributed throughout many tissues, but was most abundant in the tegument. Analysis of the cellular immune responses of vaccinated mice showed 3 of the 4 expressed clones to be highly immunogenic, inducing the secretion of large quantities of the Th1-type cytokine interferon gamma

Active clearance control system for a turbomachine

An axial compressor is provided with a cooling air manifold surrounding a portion of the shroud, and means for bleeding air from the compressor to the manifold for selectively flowing it in a modulating manner axially along the outer side of the stator/shroud to cool and shrink it during steady state operating conditions so as to obtain minimum shroud/rotor clearance conditions. Provision is also made to selectively divert the flow of cooling air from the manifold during transient periods of operation so as to alter the thermal growth or shrink rate of the stator/shroud and result in adequate clearance with the compressor rotor

Global Deposits of \u3cem\u3ein situ\u3c/em\u3e Upper Cambrian microbialites: Implications for a Cohesive Model of Origins

The existence of in situ microbialites of biological origin located in upper Cambrian rocks in western Utah presents some problems for creationists as they seek to define the boundary that separates pre-Flood deposits from those that were deposited during the Flood event itself. These microbialites are extensive in nature, covering an area of at least 2600 km2, and are stacked one atop the other in multiple beds that span a thickness of at least 300 m, but could be as thick as several km (intercalated between wackestone wedges). Other microbialites found throughout similar upper Cambrian rocks in Nevada and California are most likely representative of those in western Utah. Upper Cambrian microbialite beds have also been described from other areas in North America that circumscribe what appears to be the ancient coast of the North American craton associated with Laurentia. A total of 24 different locations span North America starting in Newfoundland, traveling down to the New York area, crossing the southern United States to Texas, then moving over to the region around Utah, California and Nevada, before continuing the trail northward through Idaho, Alberta and on into the Northwest Territories of Canada. If these microbialites indeed are in situ, then they represent vast environments that require time frames greater than the one-year period of Noah’s Flood

The Growth and Ecology of Upper Cambrian Microbialite Biostromes from the Notch Peak Formation in Utah

Exposure of carbonate rocks within the uplifted mountains of southwestern Utah presents a unique opportunity to study the growth, morphology and ecology of two upper Cambrian microbialite reefs located within the Hellnmaria Member of the Notch Peak Formation. The first reef contains meter-length, strongly elongate microbialites that grew in a deep, subtidal marine environment. These elongate microbialites formed as a result of coalescence of round ‘algal’ heads, a process known to produce compound microbialite structures in shallow water, but seldom explored as a key factor in the elongation of deep, subtidal forms that grew in ancient environments. The second reef contains lithistid sponge-microbial ‘stromatolites,’ a new type of metazoan bio-structure that has only been described from the Carboniferous and Triassic periods. This discovery has important implications when reconstructing middle to upper Cambrian reef-building communities, as these periods are assumed to have a very low diversity of metazoan reefal components. Taken together, both reefs shed light on the paleoecology and paleoenvironment of upper Cambrian microbialite reef-building communities

Feasibility study of a hand guided robotic drill for cochleostomy

The concept of a hand guided robotic drill has been inspired by an automated, arm supported robotic drill recently applied in clinical practice to produce cochleostomies without penetrating the endosteum ready for inserting cochlear electrodes. The smart tactile sensing scheme within the drill enables precise control of the state of interaction between tissues and tools in real-time. This paper reports development studies of the hand guided robotic drill where the same consistent outcomes, augmentation of surgeon control and skill, and similar reduction of induced disturbances on the hearing organ are achieved. The device operates with differing presentation of tissues resulting from variation in anatomy and demonstrates the ability to control or avoid penetration of tissue layers as required and to respond to intended rather than involuntary motion of the surgeon operator. The advantage of hand guided over an arm supported system is that it offers flexibility in adjusting the drilling trajectory. This can be important to initiate cutting on a hard convex tissue surface without slipping and then to proceed on the desired trajectory after cutting has commenced. The results for trials on phantoms show that drill unit compliance is an important factor in the design

Using a Grid-Enabled Wireless Sensor Network for Flood Management

Flooding is becoming an increasing problem. As a result there is a need to deploy more sophisticated sensor networks to detect and react to flooding. This paper outlines a demonstration that illustrates our proposed solution to this problem involving embedded wireless hardware, component based middleware and overlay networks

Chitinase and Fizz family members are a generalized feature of nematode infection with selective Upregulation of Ym1 and F10.1 by antigen-presenting cells

Ym1 and Fizz1 are secreted proteins that have been identified in a variety of Th2-mediated inflammatory settings. We originally found Ym1 and Fizz1 as highly expressed macrophage genes in a Brugia malayi infection model. Here, we show that their expression is a generalized feature of nematode infection and that they are induced at the site of infection with both the tissue nematode Litomosoides sigmodontis and the gastrointestinal nematode Nippostrongylus brasiliensis. At the sites of infection with N. brasiliensis, we also observed induction of other chitinase and Fizz family members (ChaFFs): acidic mammalian chitinase (AMCase) and Fizz2. The high expression of both Ym1 and AMCase in the lungs of infected mice suggests that abundant chitinase production is an important feature of Th2 immune responses in the lung. In addition to expression of ChaFFs in the tissues, Ym1 and Fizz1 expression was observed in the lymph nodes. Expression both in vitro and in vivo was restricted to antigen-presenting cells, with the highest expression in B cells and macrophages. ChaFFs may therefore be important effector or wound-repair molecules at the site of nematode infection, with potential regulatory roles for Ym1 and Fizz1 in the draining lymph nodes