Social problem solving in carers of young people with a first episode of psychosis: A randomized controlled trial

"Brief report

VariVis: a visualisation toolkit for variation databases

<p>Abstract</p> <p>Background</p> <p>With the completion of the Human Genome Project and recent advancements in mutation detection technologies, the volume of data available on genetic variations has risen considerably. These data are stored in online variation databases and provide important clues to the cause of diseases and potential side effects or resistance to drugs. However, the data presentation techniques employed by most of these databases make them difficult to use and understand.</p> <p>Results</p> <p>Here we present a visualisation toolkit that can be employed by online variation databases to generate graphical models of gene sequence with corresponding variations and their consequences. The VariVis software package can run on any web server capable of executing Perl CGI scripts and can interface with numerous Database Management Systems and "flat-file" data files. VariVis produces two easily understandable graphical depictions of any gene sequence and matches these with variant data. While developed with the goal of improving the utility of human variation databases, the VariVis package can be used in any variation database to enhance utilisation of, and access to, critical information.</p

A Trial Installation of High Voltage Composite Cross-arms

Four high voltage composite cross-arms have been installed as part of a non-energised trial taking place in the Scottish Highlands. The non-cylindrical geometry of their two main structural members offers improved mechanical strength-to-weight ratio compared to cylindrically-shaped insulators of similar cross-sectional area. The instrumentation system aims to monitor mechanical performance through the use of embedded strain gauges and a combination of a load cell, accelerometer and inclinometer at the cross-arm nose. An industrial data capture and control platform is used to capture sensor outputs and store them until retrieval. Networked cameras with local storage capabilities are used to capture video recordings of the cross-arms. The trial has helped establish handling, transportation and installation procedures. The first results from the instrumentation system indicate the resilience of the cross-arms to winds reaching up to 151 mph (243 km/h) while no irregularities regarding snow and ice accretion have been observed

A Grading Device

The present invention relates to grading devices (1) for reducing electrical stress in two or more electrically insulating members (29) of an electricity network tower. Preferably, a grading device (1) for reducing electrical stress in two or more electrically insulating members (29) of an electricity network tower, each electrically insulating member (29) having means for connecting the electrically insulating member (29) to an electrical power line supported by the electricity network tower, is provided, wherein: the grading device (1) includes two or more grading rings (3, 5, 7, 9), each of which is shaped so that in use it completely or substantially surrounds a respective one of the electrically insulating members (29); and the two or more grading rings (3, 5, 7, 9) are connected together

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): study protocol for a randomised control trial.

The aim of the Youth Depression Alleviation-Combined Treatment (YoDA-C) study is to determine whether antidepressant medication should be started as a first-line treatment for youth depression delivered concurrently with psychotherapy. Doubts about the use of medication have been raised by meta-analyses in which the efficacy and safety of antidepressants in young people have been questioned, and subsequent treatment guidelines for youth depression have provided only qualified support

Determinants of patient recruitment in a multicenter clinical trials group: trends, seasonality and the effect of large studies

BACKGROUND: We examined whether quarterly patient enrollment in a large multicenter clinical trials group could be modeled in terms of predictors including time parameters (such as long-term trends and seasonality), the effect of large trials and the number of new studies launched each quarter. We used the database of all clinical studies launched by the AIDS Clinical Trials Group (ACTG) between October 1986 and November 1999. Analyses were performed in two datasets: one included all studies and substudies (n = 475, total enrollment 69,992 patients) and the other included only main studies (n = 352, total enrollment 57,563 patients). RESULTS: Enrollment differed across different months of the year with peaks in spring and late fall. Enrollment accelerated over time (+27 patients per quarter for all studies and +16 patients per quarter for the main studies, p < 0.001) and was affected by the performance of large studies with target sample size > 1,000 (p < 0.001). These relationships remained significant in multivariate autoregressive modeling. A time series based on enrollment during the first 32 quarters could forecast adequately the remaining 21 quarters. CONCLUSIONS: The fate and popularity of large trials may determine the overall recruitment of multicenter groups. Modeling of enrollment rates may be used to comprehend long-term patterns and to perform future strategic planning