Efficacy of Combination of Immunotherapies in a Murine in a Murine Squamous Cell Carcinoma Model

Introduction: Head and neck squamous cell carcinomas (HNSCCs) are a type of neoplasm found in the epithelium of the oral cavity, oropharynx, nasopharynx, larynx, or hypopharynx. Recent evidence has demonstrated that 70-90% of HNSCC are associated with Human Papillomavirus (HPV), particularly strain 16 producing oncogenic proteins E6/E7. Currently, HNSCCs are treated with surgery, chemotherapy, and radiation, however immunotherapy with immune checkpoint (PD-1) blocking agents promises to improve outcomes in HNSCC. Objective: This study examined the therapeutic effects of dual and triple combination immunotherapies in a mouse model of HPV-associated HNSCC. Methods: Treatment modalities included a tumor vaccine (attenuated Listeria monocytogenes based vaccine encoding HPV16 E6/E7 (AXAL)), an immune checkpoint inhibitor targeting PD1 (RMP1-14) and topical subtherapeutic radiation. Mice were injected subcutaneously with tumor cells expressing HPV16 E6/E7 (TC-1). When tumors were established, mice were vaccinated with AXAL (3 injections) either alone and/or with anti-PDi and/or with a single dose of radiation. Results: Partial responses were observed in some mice receiving dual combination therapies. Most mice treated with triple immunotherapy revealed complete tumor regression. Discussion: Combination immunotherapy is effective in the TC-1 HNSCC model system. The results obtained set the stage for investing immune mechanism underpinning treatment-associated tumor regression

Transvesical endoscopic peritoneoscopy: intra-abdominal scarless surgery for urologic applications

For many abdominal procedures, advantages such as minimal scarring, reduced pain, and faster recovery have made laparoscopy the favored approach over traditional open surgery. The most recent minimally invasive approach is natural orifice transluminal endoscopic surgery (NOTES), which limits morbidity because this surgery does not require incision. This article reviews the history, development, and current and future applications of NOTES in the field of urology

Multiple energetic injections in a strong spike-like solar burst

An intense and fast spike-like solar burst was built up of short time scale structures superimposed on an underlying gradual emission, the time evolution of which shows remarkable proportionality between hard X-ray and microwave fluxes. The finer time structure were best defined at mm-microwaves. At the peak of the event, the finer structures repeat every 30x60ms. The more slowly varying component with a time scale of about 1 second was identified in microwave hard X-rays throughout the burst duration. It is suggested that X-ray fluxes might also be proportional to the repetition rate of basic units of energy injection (quasi-quantized). The relevant parameters of one primary energy release site are estimated both in the case where hard X-rays are produced primarily by thick-target bremsstrahlung, and when they are purely thermal. The relation of this figure to global energy considerations is discussed

Transvesical route for NOTES urological applications: advances & controversies

Natural Orifice Transluminal Endoscopic Surgery (NOTES) has emerged recently in the experimental surgical field, innovating for the passage of luminal barrier, the absence of scars and reduction of post-operative pain. Among the various ports of access (transvaginal, transgastric, transvesical and transcolonic), this paper is an update on advances & controversies of transvesical port for NOTES Urological applications

Stellar parameters for stars of the CoRoT exoplanet field

Aims:To support the computation and evolutionary interpretation of periods associated with the rotational modulation, oscillations, and variability of stars located in the CoRoT fields, we are conducting a spectroscopic survey for stars located in the fields already observed by the satellite. These observations allow us to compute physical and chemical parameters for our stellar sample. Method: Using spectroscopic observations obtained with UVES/VLT and Hydra/Blanco, and based on standard analysis techniques, we computed physical and chemical parameters ($T_{\rm{eff}}$, $\log \,(g)$, $\rm{[Fe/H]}$, $v_{\rm{mic}}$, $v_{\rm{rad}}$, $v \sin \,(i)$, and $A(\rm{Li})$) for a large sample of CoRoT targets. Results: We provide physical and chemical parameters for a sample comprised of 138 CoRoT targets. Our analysis shows the stars in our sample are located in different evolutionary stages, ranging from the main sequence to the red giant branch, and range in spectral type from F to K. The physical and chemical properties for the stellar sample are in agreement with typical values reported for FGK stars. However, we report three stars presenting abnormal lithium behavior in the CoRoT fields. These parameters allow us to properly characterize the intrinsic properties of the stars in these fields. Our results reveal important differences in the distributions of metallicity, $T_{\rm eff}$, and evolutionary status for stars belonging to different CoRoT fields, in agreement with results obtained independently from ground-based photometric surveys. Conclusions: Our spectroscopic catalog, by providing much-needed spectroscopic information for a large sample of CoRoT targets, will be of key importance for the successful accomplishment of several different programs related to the CoRoT mission, thus it will help further boost the scientific return associated with this space mission.Comment: 43 pages, 17 figures, accepted for publication in A&

Orbital and physical properties of planets and their hosts: new insights on planet formation and evolution

We explore the relations between physical and orbital properties of planets and properties of their host stars to identify the main observable signatures of the formation and evolution processes of planetary systems. We use a large sample of FGK dwarf planet hosts with stellar parameters derived in a homogeneous way from the SWEET-Cat database to study the relation between stellar metallicity and position of planets in the period-mass diagram. In the second part we use all the RV-detected planets orbiting FGK stars to explore the role of planet-disk and planet-planet interaction on the evolution of orbital properties of planets with masses above 1MJup. We show that planets orbiting metal-poor stars have longer periods than those in metal-rich systems. This trend is valid for masses at least from 10MEarth to 4MJup. Earth-like planets orbiting metal-rich stars always show shorter periods (fewer than 20 days) than those orbiting metal-poor stars. We also found statistically significant evidence that very high mass giants have on average more eccentric orbits than giant planets with lower mass.Finally, we show that the eccentricity of planets with masses higher than 4MJup tends to be lower for planets with shorter periods. Our results suggest that the planets in the P-MP diagram are evolving differently because of a mechanism that operates over a wide range of planetary masses. This mechanism is stronger or weaker depending on the metallicity of the respective system. One possibility is that planets in metal-poor disks form farther out from their central star and/or they form later and do not have time to migrate as far as the planets in metal-rich systems. The trends and dependencies obtained for very high mass planetary systems suggest that planet-disk interaction is a very important and orbit-shaping mechanism for planets in the high-mass domain. Shortened.Comment: 8 pages, 4 figures and 1 table. Accepted for publication in A&

Influência do substrato na formação de mudas de mangueira (Mangifera indica L.) em tubetes.

O objetivo deste estudo e avaliar a influencia do substrato na formacao de mudas de mangueira em tubetes.bitstream/CNPAT-2010/5386/1/Pa-070.pd

Fauna de solo: aspectos gerais e metodológicos.

Fauna de solo como agente de modificações de processos no solo. Organização de comunidades. Estrutura da comunidade. A densidade e a diversidade das comunidades de solo como indicadora de modificações ambientais . Metodologias de estudo da fauna de solo.bitstream/CNPAB-2010/27350/1/doc112.pd

Mercapturate Pathway in the Tubulocentric Perspective of Diabetic Kidney Disease

BACKGROUND: The recent growing evidence that the proximal tubule underlies the early pathogenesis of diabetic kidney disease (DKD) is unveiling novel and promising perspectives. This pathophysiological concept links tubulointerstitial oxidative stress, inflammation, hypoxia, and fibrosis with the progression of DKD. In this new angle for DKD, the prevailing molecular mechanisms on proximal tubular cells emerge as an innovative opportunity for prevention and management of DKD as well as to improve diabetic dysmetabolism. SUMMARY: The mercapturate pathway (MAP) is a classical metabolic detoxification route for xenobiotics that is emerging as an integrative circuitry detrimental to resolve tubular inflammation caused by endogenous electrophilic species. Herein we review why and how it might underlie DKD. Key Messages: MAP is a hallmark of proximal tubular cell function, and cysteine-S-conjugates might represent targets for early intervention in DKD. Moreover, the biomonitoring of urinary mercapturates from metabolic inflammation products might be relevant for the implementation of preventive/management strategies in DKD.info:eu-repo/semantics/publishedVersio