Fishes species diversity and seasonal variation in the lower basin of Nanay River, Peru

El presente trabajo informa sobre la diversidad de peces en la cuenca baja del rio Nanay, tributario del río Amazonas. Esta zona está sometida a la extracción indiscriminada de peces con usos ornamentales y de consumo directo. Utilizando redes de arrastre (10 x 2,5 m, 5 mm de luz de malla), se realizaron capturas en época de vaciante (agosto y setiembre de 2007) y creciente (febrero de 2008), en tres lugares del rio Nanay. Se colectaron 1626 individuos, correspondientes a 86 especies, de 23 familias y cinco órdenes. El número de especies vario entre 13 y 21 en época de vaciante y entre 18 y 26 especies en época de creciente. Predominaron los Characiformes, Siluriformes y Perciformes. El 76% de los individuos con tamaños menores de 10 cm. El 65% de las especies registradas tienen uso ornamental.This paper reports on the diversity of fish in the lower basin of the Nanay River, a tributary of the Amazon River. This area is subjected to indiscriminate harvesting of fish for ornamental purposes and for direct consumption. Using trawl nets (10 x 2.5 m, 5 mm mesh), we fished in the dry season (August and September 2007) and wet season (February 2008) in three places in the Nanay River. 1626 individuals were collected, corresponding to 86 species of 23 families and five orders. The number of species varied between 13 and 21 in the dry season and between 18 and 26 species during the growing season. Characiformes, Siluriformes and Perciformes were the dominant orders. 76% of individuals had small sizes. 65% of the recorded species have ornamental use

La gestión del departamento de talento humano en la capacitación y desarrollo del profesorado ecuatoriano

Resumen: Esta investigación trata sobre la reingeniería en el departamento de inspección general de las instituciones educativas con la finalidad de fortalecer y realizar cambios positivos para las instituciones de acorde a lo estipulado en nuestra ley educativa. La metodología de esta investigación fue un estudio de tipo bibliográfico. Se verifico y se comprobó las siguientes problemáticas existenciales: desvinculación del departamento de talento humano con la academia, la participación efectiva del docente en círculos de estudio (espacios generados en los horarios establecidos por el jefe de talento humano) y la falta de vínculos de redes colectivos de aprendizajes con la unidad educativa de manera nacional e internacional, es lo que se tratará en esta investigación. Existe un vacío en este tema debido a que revisando en las referencias bibliográficas las instituciones particulares en el Ecuador no apertura la movilidad para el perfeccionamiento docente. Los resultados más importantes fueron medibles y observables a través de las posturas científicas que demuestra el focus group donde se evidencia que el líder de esa muestra no gestiona la academia y ciencia dentro de su entorno educativo, es decir, no está cumpliendo su rol como autoridad que promueve la calidad de la institución educativa. La propuesta se basa en una línea operativa de los indicadores de talento humano.Palabras claves: Talento humano, capacitación, perfeccionamiento docente

Actualización sobre terminología y diagnóstico del sangrado.

El sangrado uterino anormal representa al menos un tercio de las consultas ginecológicas por causa de los síntomas de esta patología. A pesar de que no es un diagnóstico en sí, el mismo se presenta como una variación en la duración, variabilidad, volumen y frecuencia del sangrado durante la menstruación de la paciente. Al manifestarse, se debe considerar su probable etiología, por medio del acrónimo conocido como PALM-COEIN, el cual se basa en causas estructurales y no estructurales que originan el sangrado uterino anormal. Así mismo poder direccionar el diagnóstico, según las características del sangrado en la paciente

Equity, diversity, and inclusion at the Global Alliance for Genomics and Health

A lack of diversity in genomics for health continues to hinder equitable leadership and access to precision medicine approaches for underrepresented populations. To avoid perpetuating biases within the genomics workforce and genomic data collection practices, equity, diversity, and inclusion (EDI) must be addressed. This paper documents the journey taken by the Global Alliance for Genomics and Health (a genomics-based standard-setting and policy-framing organization) to create a more equitable, diverse, and inclusive environment for its standards and members. Initial steps include the creation of two groups: the Equity, Diversity, and Inclusion Advisory Group and the Regulatory and Ethics Diversity Group. Following a framework that we call "Reflected in our Teams, Reflected in our Standards," both groups address EDI at different stages in their policy development process. [Abstract copyright: © 2023 The Author(s).

FGFR1 and PROKR2 rare variants found in patients with combined pituitary hormone deficiencies

The genetic aetiology of congenital hypopituitarism (CH) is not entirely elucidated. FGFR1 and PROKR2 loss-of-function mutations are classically involved in hypogonadotrophic hypogonadism (HH), however, due to the clinical and genetic overlap of HH and CH; these genes may also be involved in the pathogenesis of CH. Using a candidate gene approach, we screened 156 Brazilian patients with combined pituitary hormone deficiencies (CPHD) for loss-of-function mutations in FGFR1 and PROKR2. We identified three FGFR1 variants (p.Arg448Trp, p.Ser107Leu and p.Pro772Ser) in four unrelated patients (two males) and two PROKR2 variants (p.Arg85Cys and p.Arg248Glu) in two unrelated female patients. Five of the six patients harbouring the variants had a first-degree relative that was an unaffected carrier of it. Results of functional studies indicated that the new FGFR1 variant p.Arg448Trp is a loss-of-function variant, while p.Ser107Leu and p.Pro772Ser present signalling activity similar to the wild-type form. Regarding PROKR2 variants, results from previous functional studies indicated that p.Arg85Cys moderately compromises receptor signalling through both MAPK and Ca2 + pathways while p.Arg248Glu decreases calcium mobilization but has normal MAPK activity. The presence of loss-of-function variants of FGFR1 and PROKR2 in our patients with CPHD is indicative of an adjuvant and/or modifier effect of these rare variants on the phenotype. The presence of the same variants in unaffected relatives implies that they cannot solely cause the phenotype. Other associated genetic and/or environmental modifiers may play a role in the aetiology of this condition

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

A escola para o mundo : a Internet resignificando o contexto escolar

Orientador: Sergio Ferreira do AmaralDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de EducaçãoMestradoEducação, Ciencia e TecnologiaMestre em Educaçã

Diversidad y variación estacional de peces en la cuenca baja del río Nanay, Perú

This paper reports on the diversity of fish in the lower basin of the Nanay River, a tributary of the Amazon River. This area is subjected to indiscriminate harvesting of fish for ornamental purposes and for direct consumption. Using trawl nets (10 x 2.5 m, 5 mm mesh), we fished in the dry season (August and September 2007) and wet season (February 2008) in three places in the Nanay River. 1626 individuals were collected, corresponding to 86 species of 23 families and five orders. The number of species varied between 13 and 21 in the dry season and between 18 and 26 species during the growing season. Characiformes, Siluriformes and Perciformes were the dominant orders. 76% of individuals had small sizes. 65% of the recorded species have ornamental use.El presente trabajo informa sobre la diversidad de peces en la cuenca baja del rio Nanay, tributario del río Amazonas. Esta zona está sometida a la extracción indiscriminada de peces con usos ornamentales y de consumo directo. Utilizando redes de arrastre (10 x 2,5 m, 5 mm de luz de malla), se realizaron capturas en época de vaciante (agosto y setiembre de 2007) y creciente (febrero de 2008), en tres lugares del rio Nanay. Se colectaron 1626 individuos, correspondientes a 86 especies, de 23 familias y cinco órdenes. El número de especies vario entre 13 y 21 en época de vaciante y entre 18 y 26 especies en época de creciente. Predominaron los Characiformes, Siluriformes y Perciformes. El 76% de los individuos con tamaños menores de 10 cm. El 65% de las especies registradas tienen uso ornamental