Resignificación de la concepción del trabajo en la sociedad laboral capitalista -con tu melia-

Los procedimientos para organizar y esquematizar la producción laboral capitalista, están siendo impuestos por las grandes elites corporativas alrededor del mundo. Estas controlan el sistema laboral, suponen una evolución y mejoramiento de este sistema, se presentan como esas entidades que trabajan para un fin común , en la que el individuo obtiene una recompensa proporcional a su producción. Sin embargo, es necesario revisar y analizar los fenómenos que envuelven a dicho régimen, que afecta de forma directa o indirecta a los trabajadores o colaboradores contemporáneos de dichas organizaciones. Esta investigación busca observar y analizar la naturaleza del fenómeno (la manipulación del sistema laboral capitalista por medio las corporaciones), la ubicación de aspectos relevantes que afectan el ambiente laboral tanto colectivo como individualmente, el contexto y los orígenes con el fin de explicar y comprender mejor su comportamiento para así establecer nuevas concepciones, que permitan proponer transformaciones a los procesos o comportamientos del sistema laboral actual."The procedures for organizing production and outline the capitalist labor, are being imposed by large corporate elites around the world. These control the labor system,represent an evolution and improvement of this system in the world, this presented as those entities that work for a ""common purpose"" in which the individual gets a reward ""proportional"" to its production. However, it is necessary to review and analyze the phenomena that surround this scheme, affecting directly or indirectly to employees or associates of such contemporary organizations. This research seeks to observe and analyze the nature of the phenomenon (manipulation of the capitalist labor by corporations), the location of relevant issues that affect the environment both collective and individual labor, the context and origins in order to explain and understand their behavior order to establish new concepts, which enable it to propose changes to processes or current employment system behaviors."Diseñador (a) IndustrialPregrad

BCN – Revitaliza. Recorrido turístico

Este Trabajo fin de Máster es un proyecto de diseño orientado al sector turístico. En su contenido se define el turismo, algunas clases existentes y al turista como actor principal. Se exponen algunos impactos que genera la práctica turística desde el marco económico, social y ambiental. Se evidencia la necesidad de utilizar a la sostenibilidad como concepto a implementar y modo de vida a seguir. Es por esto, que se expone el turismo sostenible como posible respuesta a las problemáticas ambientales y sociales que vivenciamos en el planeta. El sector turístico como sector productivo necesita de acciones que cambien comportamientos y procesos en los individuos, en las empresas y los gobiernos de los países para que se propongan nuevas maneras de conservar los recursos naturales y el bienestar de las comunidades locales. Se desarrolló el diseño de un servicio por medio de la creación de un recorrido turístico. La ciudad escogida para realizar la prueba piloto fue Barcelona; la propuesta, es descubrir, comprender y visitar la ciudad desde otras perspectivas. Esto es BCN Revitaliza.Abstract. This Final Master’s Memory is a design Project focused on the tourism sector. Its content tourism definition, some existing classes and tourists as the main actor. Also, some impacts that the tourism practice generates from the economic, social and environmental framework are exposed. This investigation shows the need to use sustainability as a concept to be implemented and as a way of life to follow. This is why sustainable tourism is exposed as a possible response to the environmental and social problems detected on the planet. The tourism sector as a productive sector needs actions that change behaviors and processes of the people as a society, of companies and governments around the world, to propose new ways to conserve natural resources and the well-being of local communities. The purpose is to design a service through the creation of a tour track. The city chosen to carry out the pilot test is Barcelona; the proposal is to discover, understand and visit the city from other perspectives. This is BCN Revitaliza

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Effect of the COVID-19 pandemic on surgery for indeterminate thyroid nodules (THYCOVID): a retrospective, international, multicentre, cross-sectional study

Background: Since its outbreak in early 2020, the COVID-19 pandemic has diverted resources from non-urgent and elective procedures, leading to diagnosis and treatment delays, with an increased number of neoplasms at advanced stages worldwide. The aims of this study were to quantify the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic; and to evaluate whether delays in surgery led to an increased occurrence of aggressive tumours. Methods: In this retrospective, international, cross-sectional study, centres were invited to participate in June 22, 2022; each centre joining the study was asked to provide data from medical records on all surgical thyroidectomies consecutively performed from Jan 1, 2019, to Dec 31, 2021. Patients with indeterminate thyroid nodules were divided into three groups according to when they underwent surgery: from Jan 1, 2019, to Feb 29, 2020 (global prepandemic phase), from March 1, 2020, to May 31, 2021 (pandemic escalation phase), and from June 1 to Dec 31, 2021 (pandemic decrease phase). The main outcomes were, for each phase, the number of surgeries for indeterminate thyroid nodules, and in patients with a postoperative diagnosis of thyroid cancers, the occurrence of tumours larger than 10 mm, extrathyroidal extension, lymph node metastases, vascular invasion, distant metastases, and tumours at high risk of structural disease recurrence. Univariate analysis was used to compare the probability of aggressive thyroid features between the first and third study phases. The study was registered on ClinicalTrials.gov, NCT05178186. Findings: Data from 157 centres (n=49 countries) on 87 467 patients who underwent surgery for benign and malignant thyroid disease were collected, of whom 22 974 patients (18 052 [78·6%] female patients and 4922 [21·4%] male patients) received surgery for indeterminate thyroid nodules. We observed a significant reduction in surgery for indeterminate thyroid nodules during the pandemic escalation phase (median monthly surgeries per centre, 1·4 [IQR 0·6-3·4]) compared with the prepandemic phase (2·0 [0·9-3·7]; p<0·0001) and pandemic decrease phase (2·3 [1·0-5·0]; p<0·0001). Compared with the prepandemic phase, in the pandemic decrease phase we observed an increased occurrence of thyroid tumours larger than 10 mm (2554 [69·0%] of 3704 vs 1515 [71·5%] of 2119; OR 1·1 [95% CI 1·0-1·3]; p=0·042), lymph node metastases (343 [9·3%] vs 264 [12·5%]; OR 1·4 [1·2-1·7]; p=0·0001), and tumours at high risk of structural disease recurrence (203 [5·7%] of 3584 vs 155 [7·7%] of 2006; OR 1·4 [1·1-1·7]; p=0·0039). Interpretation: Our study suggests that the reduction in surgical activity for indeterminate thyroid nodules during the COVID-19 pandemic period could have led to an increased occurrence of aggressive thyroid tumours. However, other compelling hypotheses, including increased selection of patients with aggressive malignancies during this period, should be considered. We suggest that surgery for indeterminate thyroid nodules should no longer be postponed even in future instances of pandemic escalation. Funding: None